In Biotelemetry, Biomedical signal such as ECG is extremely important in the diagnosis of patients in remote location and is recorded commonly with noise. Considered attention is required for analysis of ECG signal to find the patho-physiology and status of patient. In this paper, LMS and RLS algorithm are implemented on adaptive FIR filter for reducing power line interference (50Hz) and (AWGN) noise on ECG signals. The ECG signals are randomly chosen from MIT_BIH data base and de-noising using algorithms. The peaks and heart rate of the ECG signal are estimated. The measurements are taken in terms of Signal Power, Noise Power and Mean Square Error.