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by Gupta, Saurabh; Duraiswamy, B.; Satishkumar, M. N.
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This article is from Indian Journal of Pharmacology , volume 45 . Abstract Objective:: To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts Materials and Methods:: Pothos scandens L. (family- Araceae) aerial part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of P. scandens were evaluated for stabilization of mast cell in rat allergic models. The extract of P. scandens ethanolic, 50% aqueous ethanolic and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608302
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by Miodrag Marjanov Quintet
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Source: http://freemusicarchive.org/music/Miodrag_Marjanov_Quintet/Circus/
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by Mitoma
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_________________________________________________________     ARTIST REMIX CREDITS _________________________________________________________ MITOMA http://mitoma.bandcamp.com http://soundcloud.com/mitoma-altered-carbon THKAD soundcloud.com/thkad UMHELM soundcloud.com/swarmintelligence soundcloud.com/rorystjohn NICK R 61 soundcloud.com/nickr61 CHRISTOPH SCHINDLING soundcloud.com/christoph_schindling NONIMA soundcloud.com/nonima SOFTCLIP soundcloud.com/softclip RORY ST. JOHN...
Source: http://freemusicarchive.org/music/Mitoma/Interstellar__Remixes/
Free Music Archive
by J. Zagers
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fantastic full length cassette from the inimitable, inexhaustible Jeff Zagers of Savannah, GA.  
Source: http://freemusicarchive.org/music/J_Zagers/Key_Conduction/
PubMed Central
by Russell-Jones, David; Cuddihy, Robert M.; Hanefeld, Markolf; Kumar, Ajay; Gonzalez, Jose G.; Chan, Melanie; Wolka, Anne M.; Boardman, Marilyn K.
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This article is from Diabetes Care , volume 35 . Abstract OBJECTIVE: To test the safety and efficacy of exenatide once weekly (EQW) compared with metformin (MET), pioglitazone (PIO), and sitagliptin (SITA) over 26 weeks, in suboptimally treated (diet and exercise) drug-naive patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Patients were randomized to subcutaneous (SC) EQW 2.0 mg + oral placebo (n = 248), MET 2,000 mg/day + SC placebo (n = 246), PIO 45 mg/day + SC placebo (n = 163),...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263915
PubMed Central
by Attane, Camille; Foussal, Camille; Le Gonidec, Sophie; Benani, Alexandre; Daviaud, Daniele; Wanecq, Estelle; Guzman-Ruiz, Rocio; Dray, Cedric; Bezaire, Veronic; Rancoule, Chloe; Kuba, Keiji; Ruiz-Gayo, Mariano; Levade, Thierry; Penninger, Josef; Burcelin, Remy; Penicaud, Luc; Valet, Philippe; Castan-Laurell, Isabelle
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This article is from Diabetes , volume 61 . Abstract : Both acute and chronic apelin treatment have been shown to improve insulin sensitivity in mice. However, the effects of apelin on fatty acid oxidation (FAO) during obesity-related insulin resistance have not yet been addressed. Thus, the aim of the current study was to determine the impact of chronic treatment on lipid use, especially in skeletal muscles. High-fat diet (HFD)-induced obese and insulin-resistant mice treated by an apelin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266414
PubMed Central
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 68 . Abstract In the title complex, [Pd(N3)2(C12H8N2)], the PdII ion is four-coordinated in a slightly distorted square-planar environment by two N atoms of the chelating 1,10-phenanthroline (phen) ligand and two N atoms from two azide anions. The azido ligands are slightly bent with bond angles of 174.8 (4) and 174.5 (5)°. The complex mol­ecules are stacked in columns along the a axis and are...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274879
PubMed Central
by Ali, A. Jahubar; Athimoolam, S.; Bahadur, S. Asath
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 68 . Abstract The crystal structure of the title compound, C4H10N3O2+·C2HO4−, is stabilized by N—H⋯O and O—H⋯O hydrogen bonds. The anions are connected by an O—H⋯O hydrogen bond, leading to C(5) chain extending along c axis. The cations are dimerized around the corners of the unit cell, leading to an R22(14) ring motif. This leads to a cationic mol­ecular aggregation at x = 0 or 1 and an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275175
PubMed Central
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This article is from BMC Research Notes , volume 5 . Abstract Background: Tissue inhibitors of metalloproteinases (TIMPs) and the corresponding metalloproteinases are integral parts of the protease network and have been shown to be involved in cancer development and metastasis. Paradoxically, for TIMP-1, tumor promoting as well as tumor inhibitory effects have been observed. Methods: To address this paradox, we utilized the BALB/c/CT26 mouse model that reliably leads to liver metastasis after...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284431
PubMed Central
by Gomori, Eva; Pal, Jozsef; Kovacs, Bernadett; Doczi, Tamas
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This article is from Diagnostic Pathology , volume 7 . Abstract Background: Gliomas are the most common neoplasm of the brain. High-grade gliomas often resist treatment even with aggressive surgical resection and adjuvant radiation and chemotherapy. Despite the combined treatment, they frequently recur with the same or higher-grade histology. Genetic instability is commonly associated with inactivation of the normal DNA repair function and tumour suppressor genes as well as activation of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292961
PubMed Central
by Moilanen, Jaana M; Aalto, Anna-Mari; Raitanen, Jani; Hemminki, Elina; Aro, Arja R; Luoto, Riitta
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This article is from Health and Quality of Life Outcomes , volume 10 . Abstract Background and objectives: The aim of this study was to study the role of menopausal status and physical activity on quality of life. Methods: A total of 1,165 Finnish women aged 45-64 years from a national representative population-based study were followed up for 8 years. Study participants completed the Health 2000 study questionnaire and follow-up questionnaire in 2008. Ordinal logistic regression analysis was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311608
PubMed Central
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This article is from Chiropractic & Manual Therapies , volume 20 . Abstract Background: A definitive diagnosis in chiropractic clinical practice is frequently elusive, yet decisions around management are still necessary. Often, a clinical impression is made after the exclusion of serious illness or injury, and care provided within the context of diagnostic uncertainty. Rather than focussing on labelling the condition, the clinician may choose to develop a defendable management plan since...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316132
PubMed Central
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This article is from Global Health Action , volume 5 . Abstract Background: Zinc is important in adolescence because of its role in growth and sexual maturation. Adolescents from developing countries such as India may be at high risk of zinc deficiency because of unwholesome food habits and poor bioavailability of zinc from plant-based diets. Objective: (1) to study zinc status and its association with profile of other micronutrients, (2) to construct a simple tool in the form of Adolescent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328203
PubMed Central
by van Velden, Floris HP; van Beers, Paul; Nuyts, Johan; Velasquez, Linda M; Hayes, Wendy; Lammertsma, Adriaan A; Boellaard, Ronald; Loeckx, Dirk
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This article is from EJNMMI Research , volume 2 . Abstract Background: [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography (PET) is a valuable tool for monitoring response to therapy in oncology. In longitudinal studies, however, patients are not scanned in exactly the same position. Rigid and non-rigid image registration can be applied in order to reuse baseline volumes of interest (VOI) on consecutive studies of the same patient. The purpose of this study was to investigate...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349514
PubMed Central
by Fabian, Gotz; Wachter, Thomas; Schroeder, Michael
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This article is from Bioinformatics , volume 28 . Abstract Motivation: Ontologies are an everyday tool in biomedicine to capture and represent knowledge. However, many ontologies lack a high degree of coverage in their domain and need to improve their overall quality and maturity. Automatically extending sets of existing terms will enable ontology engineers to systematically improve text-based ontologies level by level.Results: We developed an approach to extend ontologies by discovering new...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371847
PubMed Central
by You, Sung-Hye; Son, Kyu Ri; Lee, Nam Joon; Suh, Jung-Keun
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This article is from Journal of Korean Neurosurgical Society , volume 51 . Abstract Dural tears can occur during spinal surgery and may lead to cerebrospinal fluid (CSF) leakage which is rarely involved in remote cerebellar hemorrhage. Only a few of cases of simultaneous cerebral and cerebellar hemorrhage have been reported in the English literature. We experienced a case of multiple remote cerebral and cerebellar hemorrhages in a 63-year-old man who exhibited no significant neurologic deficits...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377885
PubMed Central
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This article is from The Journal of Advanced Prosthodontics , volume 4 . Abstract PURPOSE: Study was conducted to determine and assess the effect of different type of denture adhesives on the incisal bite force of complete denture wearers until the dislodgement of upper denture, using pressure transducer. MATERIALS AND METHODS: 30 patients out of 100 were included in the study. Based on the Kapur's method of scoring denture retention and stability, these patients were divided into 3 groups-...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381210
PubMed Central
by Maroufyan, Elham; Kasim, Azhar; Ebrahimi, Mahdi; Loh, Tech Chwen; Bejo, Mohd Hair; Zerihun, Hailemariam; Hosseni, Fatemeh; Goh, Yong Meng; Farjam, Abdoreza Soleimani
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This article is from Lipids in Health and Disease , volume 11 . Abstract Background: Infectious bursal disease (IBD) results in economic loss due to mortality, reduction in production efficiency and increasing the usage of antibiotics. This study was carried out to investigate the modulatory roles of dietary n-3 polyunsaturated fatty acids (PUFA) enrichment in immune response and performance of IBD challenged broiler chickens. Methods: A total of 300 day old male broiler chicks were assigned to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398282
PubMed Central
by de Almeida, Julio C; Alves, Clodoaldo L; de Abreu, Luiz Carlos; Sato, Monica A; Fonseca, Fernando L; de Mello Monteiro, Carlos B; Vanderlei, Luiz Carlos M; Macedo, Hugo; Tavares, Carlos M; Herrero, Dafne; Rodrigues, Luciano MR; Valenti, Vitor E
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This article is from International Archives of Medicine , volume 5 . Abstract In this minireview we describe the involvement of the atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role and exerts complex effects on the cardio-circulatory hemodynamics, it is produced by the left atrium and has a key role in regulating sodium and water balance in mammals and humans. The dominant stimulus for its release is atrial wall tension,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395876
PubMed Central
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This article is from Small GTPases , volume 3 . Abstract Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer. Recent studies have elucidated important roles for Rho GTPases in the establishment and maintenance of polarity prior to and during cell migration. Here, we show that Tiam1, a specific activator of the small GTPase Rac, is required for the polarized outgrowth of protrusions in primary astrocytes...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398916
PubMed Central
by Herbert, Rosalind P; Harris, Julie; Chong, Kim Pei; Chapman, Jamie; West, Adrian K; Chuah, Meng Inn
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This article is from Journal of Neuroinflammation , volume 9 . Abstract Background: The primary olfactory pathway is a potential route through which microorganisms from the periphery could potentially access the central nervous system. Our previous studies demonstrated that if the olfactory epithelium was damaged, bacteria administered into the nasal cavity induced nitric oxide production in olfactory ensheathing cells. This study investigates the cytokine profile of olfactory tissues as a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411416
PubMed Central
by Christakis, D. A.; Ramirez, J. S. B.; Ramirez, J. M.
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This article is from Scientific Reports , volume 2 . Abstract Observational studies in humans have found associations between overstimulation in infancy via excessive television viewing and subsequent deficits in cognition and attention. We developed and tested a mouse model of overstimulation whereby p10 mice were subjected to audio (70 db) and visual stimulation (flashing lights) for six hours per day for a total of 42 days. 10 days later cognition and behavior were tested using the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409385
PubMed Central
by Sordi, G.; Semon, P.; Haule, K.; Tremblay, A.-M. S.
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This article is from Scientific Reports , volume 2 . Abstract The pseudogap refers to an enigmatic state of matter with unusual physical properties found below a characteristic temperature T* in hole-doped high-temperature superconductors. Determining T* is critical for understanding this state. Here we study the simplest model of correlated electron systems, the Hubbard model, with cluster dynamical mean-field theory to find out whether the pseudogap can occur solely because of strong coupling...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409386
PubMed Central
by Raemaekers, Tim; Peric, Aleksandar; Baatsen, Pieter; Sannerud, Ragna; Declerck, Ilse; Baert, Veerle; Michiels, Christine; Annaert, Wim
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This article is from The EMBO Journal , volume 31 . Abstract The GTPase Arf6 and its exchange factor EFA6A promote internalization of the Ig-like molecule Telencephalin in hippocampal neurons leading to the maturation of filopodia into dendritic spines, important for synapse formation.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411082
PubMed Central
by Moran, Yehu; Fredman, David; Szczesny, Pawel; Grynberg, Marcin; Technau, Ulrich
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This article is from Molecular Biology and Evolution , volume 29 . Abstract In this work, we report likely recurrent horizontal (lateral) gene transfer events of genes encoding pore-forming toxins of the aerolysin family between species belonging to different kingdoms of life. Clustering based on pairwise similarity and phylogenetic analysis revealed several distinct aerolysin sequence groups, each containing proteins from multiple kingdoms of life. These results strongly support at least six...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424411
PubMed Central
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This article is from International Journal of Molecular Sciences , volume 13 . Abstract Advanced glycation end products (AGEs) and inflammation contribute to the development of diabetic complications. Astragalus membranaceus has properties of immunological regulation in many diseases. The aim of this study was to determine the function of A. membranaceus extract (AME) on the AGE-induced inflammatory response in Ana-1 macrophages. The viability of cells treated with AME or AGEs was evaluated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430240
PubMed Central
by Wyres, Kelly L; Lambertsen, Lotte M; Croucher, Nicholas J; McGee, Lesley; von Gottberg, Anne; Linares, Josefina; Jacobs, Michael R; Kristinsson, Karl G; Beall, Bernard W; Klugman, Keith P; Parkhill, Julian; Hakenbeck, Regine; Bentley, Stephen D; Brueggemann, Angela B
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This article is from Genome Biology , volume 13 . Abstract Background: Streptococcus pneumoniae, also called the pneumococcus, is a major bacterial pathogen. Since its introduction in the 1940s, penicillin has been the primary treatment for pneumococcal diseases. Penicillin resistance rapidly increased among pneumococci over the past 30 years, and one particular multidrug-resistant clone, PMEN1, became highly prevalent globally. We studied a collection of 426 pneumococci isolated between 1937...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580495
PubMed Central
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This article is from Turkish Journal of Hematology , volume 29 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986962
PubMed Central
by Mirshemirani, AliReza; Khaleghnejad-tabari, Ahmad; Kouranloo, Jaefar; Sadeghian, Naser; Rouzrokh, Mohsen; Roshanzamir, Fatolah; Razavi, Sajad; Sayary, Ali Akbar; Imanzadeh, Farid
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This article is from Middle East Journal of Digestive Diseases , volume 4 . Abstract BACKGROUNDThe purpose of this study was to evaluate the characteristics, management, and outcomes of disc battery ingestion in children.METHODSWe reviewed the medical records of children admitted to Mofid Children’s Hospital due to disc battery ingestion from January 2006 to January 2010. Clear history, clinical symptoms and results of imaging studies revealed diagnosis of disc battery ingestion in suspected...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017686
PubMed Central
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This article is from Anesthesiology and Pain Medicine , volume 1 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018690
PubMed Central
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This article is from Asian-Australasian Journal of Animal Sciences , volume 26 . Abstract The objective of this study was to get a comprehensive understanding of how genes in chicken shell gland modulate eggshell strength at the early stage of active calcification. Four 32-week old of purebred Xianju hens with consistent high or low shell breakage strength were grouped into two pairs. Using Affymetrix Chicken Array, a whole-transcriptome analysis was performed on hen’s shell gland at 9 h post...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093333
PubMed Central
by Collado, Maria Carmen; Bauerl, Christine; Perez-Martinez, Gaspar
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This article is from Microbial Ecology in Health and Disease , volume 23 . Abstract The human body harbors complex communities of microbes that play a prominent role in human health. Detailed characterization of the microbiota in the target population forms the basis of probiotic use. Probiotics are defined as live bacterial preparations with clinically documented health effects in humans, and independent of their genus and species, probiotic strains are unique and their beneficial properties...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747743
PubMed Central
by Teronpi, Valentina; Singh, H. T.; Tamuli, A. K.; Teron, Robindra
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This article is from Ancient Science of Life , volume 32 . Abstract Background:: Traditional or folk medicine is still prevalent among the Karbis as means of primary health-care. Traditional medicine is not only a source of healing, but the practice is also an important part of their religion and culture. Aim:: The aim of the present study is to discuss the use of ichthyofauna in traditional health-care practices among the Karbis and other ethnic tribes of Karbi Anglong district, Assam. Setting...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807965
PubMed Central
by McMahon, Catherine J; Hopkins, Stephen; Vail, Andy; King, Andrew T; Smith, Debi; Illingworth, Karen J; Clark, Simon; Rothwell, Nancy J; Tyrrell, Pippa J
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This article is from Journal of Neurointerventional Surgery , volume 5 . Abstract Background: The mechanism of development of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is poorly understood. Inflammatory processes are implicated in the development of ischemic stroke and may also predispose to the development of DCI following SAH. The objective of this study was to test whether concentrations of circulating inflammatory markers (C-reactive protein (CRP),...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812893
PubMed Central
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This article is from Journal of Surgical Case Reports , volume 2012 . Abstract Haemosuccus pancreaticus (HP) is a rare life-threatening cause of intermittent upper Gastrointestinal bleeding. We report the first documented case of HP due to bleeding from aberrant vessels originating from the coeliac trunk feeding the head of the pancreas. Our patient underwent initial surgery and subsequent angio-embolization. This case report describes the challenges faced during the diagnosis and treatment.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855220
PubMed Central
by Jiang, Chunling; Li, Xianyin; Phillips, Michael R.; Xu, Yongchen
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This article is from Shanghai Archives of Psychiatry , volume 25 . Abstract Background: Suicide rates in rural China are two-fold to three-fold those in urban China but the reasons for this large difference remain unclear. Aim: Assess the characteristics and risk factors of medically serious suicide attempts in rural China. Methods: A comprehensive 2 to 3 hour structured interview was administered by psychiatrists to 297 medically serious suicide attempters (defined as those who remained in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054523
PubMed Central
by Barbini, Luciana; Tadey, Luciana; Fernandez, Silvina; Bouzas, Belen; Campos, Rodolfo
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This article is from Virology Journal , volume 9 . Abstract Background: HBV-X protein is associated with the pathogenesis of HBV related diseases, specially in hepatocellular carcinomas of chronic patients. Genetic variability of the X gene includes genotypic specific variations and mutations emerging during chronic infection. Its coding sequence overlaps important regions for virus replication, including the basal core promoter. Differences in the X gene may have implications in biological...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432627
PubMed Central
by Chen, Chih-Hao; Lee, Shih-Yi; Chang, Ho; Liu, Hung-Chang; Chen, Chao-Hung; Huang, Wen-Chien
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This article is from Journal of Cardiothoracic Surgery , volume 7 . Abstract Thoracoscopic Surgery is in common use in routine surgical practice. With the advancement of the various techniques and instruments required, mini wounds and fewer thoracoports become practical in recent years. Here, we report our experience of performing lobectomy with radical lymph node dissection in 3 patients using regular straight endoscopic instruments. We demonstrate the feasibility of such techniques and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431998
PubMed Central
by Hauser, Kurt F; Fitting, Sylvia; Dever, Seth M; Podhaizer, Elizabeth M; Knapp, Pamela E
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This article is from Current HIV Research , volume 10 . Abstract Opiate abuse and HIV-1 have been described as interrelated epidemics, and even in the advent of combined anti-retroviral therapy, the additional abuse of opiates appears to result in greater neurologic and cognitive deficits. The central nervous system (CNS) is particularly vulnerable to interactive opiate-HIV-1 effects, in part because of the unique responses of microglia and astroglia. Although neurons are principally...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431547
PubMed Central
by Fun, Hoong-Kun; Quah, Ching Kheng; Nayak, Prakash S.; Narayana, B.; Sarojini, B. K.
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 68 . Abstract In the title compound, C11H9ClN2OS, the thia­zole ring is nearly planar (r.m.s. deviation = 0.003 Å) and forms a dihedral angle of 64.18 (7)° with the bezene ring. In the crystal, inversion dimers linked by pairs of N—H⋯Nt (t = thia­zole) hydrogen bonds generate R22(8) loops.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435701
PubMed Central
by Son, Han Kyeong; Cha, Young Sun; Suh, Hwi; Ki, Chang-Seok; Shin, Yong Beom
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This article is from Annals of Rehabilitation Medicine , volume 36 . Abstract Myotonic dystrophy is the most common autosomal dominant myopathy in adults. Our patient, a 41 year-old female suffering from myotonic muscular dystrophy, developed upper thoracic myelopathy due to hypertrophy of the ligamentum flavum and the posterior longitudinal ligament. She had a typical hatchet face and ptosis with "head hanging forward" appearance caused by neck weakness. Motor weakness, sensory...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438427
PubMed Central
by Yao, Mao-jin; Chen, Gang; Zhao, Ping-ping; Lu, Ming-hua; Jian, Jiang; Liu, Mo-fang; Yuan, Xiao-bing
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This article is from BMC Genomics , volume 13 . Abstract Background: The morphogenesis of the cerebral cortex depends on the precise control of gene expression during development. Small non-coding RNAs, including microRNAs and other groups of small RNAs, play profound roles in various physiological and pathological processes via their regulation of gene expression. A systematic analysis of the expression profile of small non-coding RNAs in developing cortical tissues is important for clarifying...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441217
PubMed Central
by Correia, Sandra F. H.; Antunes, Paulo; Pecoraro, Edison; Lima, Patricia P.; Varum, Humberto; Carlos, Luis D.; Ferreira, Rute A. S.; Andre, Paulo S.
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This article is from Sensors (Basel, Switzerland) , volume 12 . Abstract In this work we proposed a relative humidity (RH) sensor based on a Bragg grating written in an optical fiber, associated with a coating of organo-silica hybrid material prepared by the sol-gel method. The organo-silica-based coating has a strong adhesion to the optical fiber and its expansion is reversibly affected by the change in the RH values (15.0–95.0%) of the surrounding environment, allowing an increased...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444079
PubMed Central
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This article is from BMC Genomics , volume 13 . Abstract Background: Previous work has shown that the hypersaline-adapted archaeon, Halobacterium salinarum NRC-1, is highly resistant to oxidative stress caused by exposure to hydrogen peroxide, UV, and gamma radiation. Dynamic alteration of the gene regulatory network (GRN) has been implicated in such resistance. However, the molecular functions of transcription regulatory proteins involved in this response remain unknown. Results: Here we have...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443676
PubMed Central
by McGovern, Susan L; Qi, Yuan; Pusztai, Lajos; Symmans, William F; Buchholz, Thomas A
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This article is from Breast Cancer Research : BCR , volume 14 . Abstract Introduction: Centromere protein A (CENP-A), an essential centromere protein, has been associated with high grade cancers. This study was undertaken to determine if CENP-A is a prognostic factor for breast cancer patients not receiving systemic therapy or predictive of response to tamoxifen or neoadjuvant chemotherapy. Methods: mRNA levels of CENP-A and CENP-B, a centromere protein that binds independently of CENP-A, were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446334
PubMed Central
by Zhi, Zhongwei; Cepurna, William O.; Johnson, Elaine C.; Morrison, John C.; Wang, Ruikang K.
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This article is from Biomedical Optics Express , volume 3 . Abstract In this paper, we demonstrate the use of optical coherence tomography/optical microangiography (OCT/OMAG) to image and measure the effects of acute intraocular pressure (IOP) elevation on retinal, choroidal and optic nerve head (ONH) perfusion in the rat eye. In the experiments, IOP was elevated from 10 to 100 mmHg in 10 mmHg increments. At each IOP level, three-dimensional data volumes were captured using an ultrahigh...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447563
PubMed Central
by Liu, Xindong; Yan, Xiaowei; Zhong, Bo; Nurieva, Roza I.; Wang, Aibo; Wang, Xiaohu; Martin-Orozco, Natalia; Wang, Yihong; Chang, Seon Hee; Esplugues, Enric; Flavell, Richard A.; Tian, Qiang; Dong, Chen
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This article is from The Journal of Experimental Medicine , volume 209 . Abstract A novel Bcl6 reporter mouse is used to dissect the developmental requirements, plasticity, and genetic profile of Tfh cells.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457730
PubMed Central
by Tragardh, Elin; Johansson, Liselott; Olofsson, Camilla; Valind, Sven; Edenbrandt, Lars
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This article is from BMC Medical Informatics and Decision Making , volume 12 . Abstract Background: In myocardial perfusion scintigraphy (MPS), typically a stress and a rest study is performed. If the stress study is considered normal, there is no need for a subsequent rest study. The aim of the study was to determine whether nuclear medicine technologists are able to assess the necessity of a rest study. Methods: Gated MPS using a 2-day 99mTc protocol for 121 consecutive patients were studied....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457849
PubMed Central
by Del Coso, Juan; Salinero, Juan Jose; Gonzalez-Millan, Cristina; Abian-Vicen, Javier; Perez-Gonzalez, Benito
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This article is from Journal of the International Society of Sports Nutrition , volume 9 . Abstract Background: Energy drinks have become the most used caffeine-containing beverages in the sport setting. The aim of this study was to determine the effects of two doses of a caffeine-containing energy drink on muscle performance during upper- and lower-body power-load tests. Methods: In a randomized order, twelve active participants ingested 1 and 3 mg of caffeine per kg of body weight using a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461468
PubMed Central
by Zhao, Hongwei; Zhang, Hong; Wu, Hui; Li, Hui; Liu, Lei; Guo, Jian; Li, Chenyang; Shih, David Q; Zhang, Xiaolan
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This article is from BMC Gastroenterology , volume 12 . Abstract Background: Intestinal hyper-permeability plays a critical role in the etiopathogenesis of inflammatory bowel disease (IBD) by affecting the penetration of pathogens, toxic compounds and macromolecules. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D, has been shown to be an important regulator of IBD and recent epidemiology suggests that patients with IBD have an impaired vitamin D status. The purpose of this...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464614
PubMed Central
by Kim, Seok Jin; Park, Yong; Kim, Byung Soo; Kim, Insun; Ko, Young Hye; Kim, Won Seog
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This article is from The Korean Journal of Hematology , volume 47 . Abstract Background: Extranodal natural killer (NK)/T-cell lymphoma is a subtype of lymphoma that is derived from NK cells. It is considered as an aggressive form of non-Hodgkin's lymphoma because of frequent relapses and resistance to treatment. Relapsed NK/T-cell lymphoma often follows a fulminant course that is refractory to conventional chemotherapy treatment. Methods: Several patients with extranodal NK/T-cell lymphoma...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464337
PubMed Central
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This article is from Health Policy and Planning , volume 27 . Abstract Public accountability has re-emerged as a top priority for health systems all over the world, and particularly in developing countries where governments have often failed to provide adequate public sector services for their citizens. One approach to strengthening public accountability is through direct involvement of clients, users or the general public in health delivery, here termed ‘community accountability’. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465752
PubMed Central
by Almassinokiani, Fariba; Alebouyeh, Mahmood Reza; Entesari, Farshad; Sezavar Seyedi, Seyed Hashem; Almasi, Alireza; Akbari, Hossein; Saidi, Hossein; Homam, Homa
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This article is from The Journal of Tehran Heart Center , volume 7 . Abstract Acute myocardial infarction (MI) during pregnancy is rare and MI due to Prinzmetal’s angina is much rarer. We present a 35-year-old, obese, multigravida, and pre-eclamptic woman, who developed acute anterior wall MI at the 30th week of gestation. On coronary angiography, the second obtuse marginal branch was totally occluded and the right coronary artery (RCA) was normal. Three days later, she had chest pain and ST...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466900
PubMed Central
by Ahn, Seun Joo; Kim, Dong Kyu; Kim, Soon Sun; Bae, Chang Bum; Cho, Hyo Jung; Kim, Han Gyeol; Kim, Young Jip; Lee, Joo Ho; Lee, Hyo Jin; Lee, Mi Yeon; Kim, Kee Bum; Cho, Jin Hee; Cho, Sung Won; Cheong, Jae Youn
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This article is from Clinical and molecular hepatology , volume 18 . Abstract Background/Aims: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determines the disease outcome in hepatitis B virus (HBV)-infected individuals, and verified the association between ApoE genotype and the occurrence of hepatocellular carcinoma (HCC) in patients...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467433
PubMed Central
by Javanbakht, MH; Daneshpazhooh, M; Chams-Davatchi, C; Eshraghian, MR; Zarei, M; Chamari, M; M, Djalali
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This article is from Iranian Journal of Public Health , volume 41 . Abstract Background:: Pemphigus vulgaris is a life threatening, blistering skin disease. It is an autoimmune abnormality. Due to involvement of oral cavity and pharynx, patients are at risk of nutrients deficiency. The aim of this study was to evaluate the status of selenium, copper, and zinc in these patients. Methods:: In a case-control study, 43 newly diagnosed pemphigus vulgaris patients were compared with 58 healthy people...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468983
PubMed Central
by Ahmad, Zalinah; Rasouli, Mina; Azman, Ahmad Zaid Fattah; Omar, Abdul Rahman
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This article is from BMC Biotechnology , volume 12 . Abstract Background: Gene therapy could provide an effective treatment of diabetes. Previous studies have investigated the potential for several cell and tissue types to produce mature and active insulin. Gut K and L-cells could be potential candidate hosts for gene therapy because of their special features. Results: In this study, we isolated gut K and L-cells to compare the potential of both cell types to produce insulin when exposed to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469342
PubMed Central
by Castaneda, Elizabeth; Agudelo, Clara Ines; De Antonio, Rodrigo; Rosselli, Diego; Calderon, Claudia; Ortega-Barria, Eduardo; Colindres, Romulo E
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This article is from BMC Infectious Diseases , volume 12 . Abstract Background: Pneumococcal conjugate vaccines (PCVs) are in the process of implementation in Latin America. Experience in developed countries has shown that they reduce the incidence of invasive and non-invasive disease. However, there is evidence that the introduction of PCVs in universal mass vaccination programs, combined with inappropriate and extensive use of antibiotics, could be associated to changes in non-PCV serotypes,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475047
PubMed Central
by Giannasi, Lilian Chrystiane; Matsui, Miriam Yumi; de Freitas Batista, Sandra Regina; Hardt, Camila Teixeira; Gomes, Carla Paes; Amorim, Jose Benedito Oliveira; de Carvalho Aguiar, Isabella; Collange, Luanda; dos Reis dos Santos, Israel; Dias, Ismael Souza; de Oliveira, Claudia Santos; de Oliveira, Luis Vicente Franco; Gomes, Monica Fernandes
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This article is from BMC Musculoskeletal Disorders , volume 13 . Abstract Background: Few studies demonstrate effectiveness of therapies for oral rehabilitation of patients with cerebral palsy (CP), given the difficulties in chewing, swallowing and speech, besides the intellectual, sensory and social limitations. Due to upper airway obstruction, they are also vulnerable to sleep disorders. This study aims to assess the sleep variables, through polysomnography, and masticatory dynamics, using...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479060
PubMed Central
by Liana, Devi D.; Raguse, Burkhard; Gooding, J. Justin; Chow, Edith
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This article is from Sensors (Basel, Switzerland) , volume 12 . Abstract Paper-based sensors are a new alternative technology for fabricating simple, low-cost, portable and disposable analytical devices for many application areas including clinical diagnosis, food quality control and environmental monitoring. The unique properties of paper which allow passive liquid transport and compatibility with chemicals/biochemicals are the main advantages of using paper as a sensing platform. Depending on...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478794
PubMed Central
by Sridharan, Sriram; Layek, Ritwik; Datta, Aniruddha; Venkatraj, Jijayanagaram
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This article is from BMC Genomics , volume 13 . Abstract Background: Oxidative stress is a consequence of normal and abnormal cellular metabolism and is linked to the development of human diseases. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage; conversely the failure of the oxidative stress response mechanism can induce aberrant cellular behavior leading to diseases such as neurodegenerative disorders and cancer. Thus,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481480
PubMed Central
by Xu, Ye; Willems, Andrew; Au-yeung, Catherine; Tahlan, Kapil; Nodwell, Justin R.
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This article is from mBio , volume 3 . Abstract Many microorganisms produce secondary metabolites that have antibiotic activity. To avoid self-inhibition, the producing cells often encode cognate export and/or resistance mechanisms in the biosynthetic gene clusters for these molecules. Actinorhodin is a blue-pigmented antibiotic produced by Streptomyces coelicolor. The actAB operon, carried in the actinorhodin biosynthetic gene cluster, encodes two putative export pumps and is regulated by the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482498
PubMed Central
by Lee, Young-ju; Shin, Byung Seok; Lee, In Ho; Ohm, Joon Young; Lee, Byung-seok; Ahn, Moonsang; Kim, Ho Jun
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This article is from Korean Journal of Radiology , volume 13 . Abstract A 67-year-old woman presented with memory impairment and behavioral changes. Brain MRI indicated hepatic encephalopathy. Abdominal CT scans revealed an intrahepatic portosystemic venous shunt that consisted of two shunt tracts to the aneurysmal sac that communicated directly with the right hepatic vein. The large tract was successfully occluded by embolization using the newly available AMPLATZERTM Vascular Plug II and the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484308
PubMed Central
by Hansen, James E.; Sun, Xing-Guo; Stringer, William W.
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This article is from Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease , volume 1 . Abstract Background: The complexity of cardiopulmonary exercise testing data and their displays tends to make assessment of patients, including those with heart failure, time consuming. Methods and Results: We postulated that a new single display that uses concurrent values of oxygen uptake / ventilation versus carbon dioxide output / ventilation ratios (–versus–), plotted...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487328
PubMed Central
by Kozloff, M F; Martin, L P; Krzakowski, M; Samuel, T A; Rado, T A; Arriola, E; De Castro Carpeno, J; Herbst, R S; Tarazi, J; Kim, S; Rosbrook, B; Tortorici, M; Olszanski, A J; Cohen, R B
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This article is from British Journal of Cancer , volume 107 . Abstract Background:: This phase I dose-finding trial evaluated safety, efficacy and pharmacokinetics of axitinib, a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors, combined with platinum doublets in patients with advanced non-small cell lung cancer (NSCLC) and other solid tumours. Methods:: In all, 49 patients received axitinib 5 mg twice daily (b.i.d.) with paclitaxel/carboplatin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494447
PubMed Central
by Nakamichi, Kazuo; Mizusawa, Hidehiro; Yamada, Masahito; Kishida, Shuji; Miura, Yoshiharu; Shimokawa, Toshio; Takasaki, Tomohiko; Lim, Chang-Kweng; Kurane, Ichiro; Saijo, Masayuki
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This article is from BMC Neurology , volume 12 . Abstract Background: Progressive multifocal leukoencephalopathy (PML), a rare but fatal demyelinating disease caused by JC virus (JCV), occurs mainly in immunocompromised patients. As PML develops in individuals with various underlying disorders sporadically and infrequently, a nationwide survey of PML is difficult. This study was conducted to elucidate the characteristics of PML in Japan through an internet-assisted laboratory surveillance...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495800
PubMed Central
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This article is from Reproductive Biology and Endocrinology : RB&E , volume 10 . Abstract Background: Ovarian aging patterns differ between races, and appear to affect fertility treatment outcomes. What causes these differences is, however, unknown. Variations in ovarian aging patterns have recently been associated with specific ovarian genotypes and sub-genotypes of the FMR1 gene. We, therefore, attempted to determine differences in how functional ovarian reserve (FOR) changes with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495196
PubMed Central
by Chernysh, Irina N.; Nagaswami, Chandrasekaran; Purohit, Prashant K.; Weisel, John W.
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This article is from Scientific Reports , volume 2 . Abstract Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clots and thrombi are stable structures until proteolytic digestion. On the contrary, using the technique of fluorescence...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501649
This article is from Experimental and Therapeutic Medicine , volume 4 . Abstract ALZET® osmotic pumps are implantable devices used in animals for the continuous infusion of drugs or proteins at controlled rates from 1 day to 4 weeks. Pumps have been used successfully in a number of studies on the effects of controlled delivery of a wide range of experimental agents, independent of their properties. In the present study, use of these pumps was made in mice with diabetic nephropathy. Plasminogen...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501414
PubMed Central
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This article is from BMC Research Notes , volume 5 . Abstract Background: The implementation of capitated payment has driven medical institutions through developing balance billing for medical services. By exploring the patients’ decision-making factors on different self-pay items, a reference for the pricing and sales strategy for the related products can be formed. The major purposes of this study were to analyze the determinants of preoperative selection and postoperative satisfaction with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506463
This article is from Clinical Sarcoma Research , volume 2 . Abstract The current AJCC version 7 staging system is a lugubrious means to classify gastrointestinal stromal tumors with respect to their risk and need for adjuvant systemic therapy. The rule of fives, suggested here, is a means to quickly assess whether a given gastrointestinal stromal tumor is low vs intermediate-high risk.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507895
PubMed Central
by Orrell, C; Levison, J; Ciaranello, A; Bekker, L; Kuritzkes, D; Freedberg, K; Wood, R
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This article is from Journal of the International AIDS Society , volume 15 . Abstract Introduction: HIV-1 resistance data to inform treatment sequencing are limited for children with virological failure on first- and second-line antiretroviral therapy (ART) in Sub-Saharan Africa. Methods: HIV-1-infected children aged ≤15 years were retrospectively identified from an ART cohort in Cape Town, South Africa (2003 to 2010). First-line ART was either non-nucleoside reverse transcriptase inhibitor...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512453
This article is from BMC Evolutionary Biology , volume 12 . Abstract Background: Small nucleolar (sno)RNAs are required for posttranscriptional processing and modification of ribosomal, spliceosomal and messenger RNAs. Their presence in both eukaryotes and archaea indicates that snoRNAs are evolutionarily ancient. The location of some snoRNAs within the introns of ribosomal protein genes has been suggested to belie an RNA world origin, with the exons of the earliest protein-coding genes having...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511168
PubMed Central
by Madeley, Lee G.; Lemmerer, Andreas; Michael, Joseph P.
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 68 . Abstract The asymmetric unit of the racemic title compound, C10H16N2S2, a C2-symmetric bis­(thiol­actam), contains one half-mol­ecule, the complete mol­ecule being generated by a twofold axis symmetry operation. The five-membered ring is nearly planar, with a maximum deviation of 0.025 (1) Å. In the crystal, the mol­ecules are linked via weak C—H⋯S inter­actions, forming infinite chains...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515298
PubMed Central
by Thavarajah, Rooban; Mudimbaimannar, Vidya Kazhiyur; Elizabeth, Joshua; Rao, Umadevi Krishnamohan; Ranganathan, Kannan
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This article is from Journal of Oral and Maxillofacial Pathology : JOMFP , volume 16 . Abstract Formaldehyde is the widely employed fixative that has been studied for decades. The chemistry of fixation has been studied widely since the early 20th century. However, very few studies have been focused on the actual physics/chemistry aspect of process of this fixation. This article attempts to explain the chemistry of formaldehyde fixation and also to study the physical aspects involved in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519217
PubMed Central
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This article is from BMC Bioinformatics , volume 13 . Abstract Background: Numerous models for use in interpreting quantitative PCR (qPCR) data are present in recent literature. The most commonly used models assume the amplification in qPCR is exponential and fit an exponential model with a constant rate of increase to a select part of the curve. Kinetic theory may be used to model the annealing phase and does not assume constant efficiency of amplification. Mechanistic models describing the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519511
PubMed Central
by Cereda, Anna; Carey, John C
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This article is from Orphanet Journal of Rare Diseases , volume 7 . Abstract The trisomy 18 syndrome, also known as Edwards syndrome, is a common chromosomal disorder due to the presence of an extra chromosome 18, either full, mosaic trisomy, or partial trisomy 18q. The condition is the second most common autosomal trisomy syndrome after trisomy 21. The live born prevalence is estimated as 1/6,000-1/8,000, but the overall prevalence is higher (1/2500-1/2600) due to the high frequency of fetal...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520824
PubMed Central
by Bianca, Carlo; Chiacchio, Ferdinando; Pappalardo, Francesco; Pennisi, Marzio
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This article is from BMC Bioinformatics , volume 13 . Abstract The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521211
PubMed Central
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This article is from Diabetes & Metabolism Journal , volume 36 . Abstract Insulin resistance (IR) is now considered as a chronic and low level inflammatory condition. It is closely related to altered glucose tolerance, hypertriglyceridemia, abdominal obesity, and coronary heart disease. IR is accompanied by the increase in the levels of inflammatory cytokines like interleukin-1 and 6, tumor necrosis factor-α. These inflammatory cytokines also play a crucial part in pathogenesis and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530710
PubMed Central
by Chavez, Shawn L.; Loewke, Kevin E.; Han, Jinnuo; Moussavi, Farshid; Colls, Pere; Munne, Santiago; Behr, Barry; Reijo Pera, Renee A.
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This article is from Nature Communications , volume 3 . Abstract Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50–80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hypothesis that blastomere behaviour may reflect ploidy during the first two cleavage divisions. We demonstrate...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535341
PubMed Central
by Duan, Guotao; Su, Fuhai; Xu, Wen; Zhang, Cunlin; Cai, Weiping
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This article is from Nanoscale Research Letters , volume 7 . Abstract Terahertz (THz) time-domain spectroscopy is carried out for micro/nanostructured periodic Au/dielectric sphere arrays on Si substrate. We find that the metal-insulator transition can be achieved in THz bandwidth via varying sample parameters such as the thickness of the Au shell and the diameter of the Au/dielectric sphere. The Au/polystyrene sphere arrays do not show metallic THz response when the Au shell thickness is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533953
PubMed Central
by Koshenkov, Vadim P.; Pahuja, Anil K.; Nemeth, Zoltan H.; Abkin, Alexander; Carter, Mitchel S.
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This article is from JSLS : Journal of the Society of Laparoendoscopic Surgeons , volume 16 . Abstract The authors found that exploratory laparoscopy during splenectomy was more accurate than preoperative imaging with CT scan for detection of accessory spleens.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535795
PubMed Central
by Hosseinzadeh Nik, T.; Ghadirian, H.; Ahmadabadi, M. Nili; Shahhoseini, T.; Haj-Fathalian, M.
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This article is from Journal of Dentistry (Tehran, Iran) , volume 9 . Abstract Objective:: Most published results about the characteristics of NiTi wires are based on the mechanical laboratory tests on the as-received wires.The purpose of this study was to investigate the effect of saliva on load-deflection characteristics of superelastic NiTi wires. Materials and Methods:: In this experimental study, 15 wires of three kinds of superelastic NiTi wires (Sentalloy, Force I and Truflex) were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536451
PubMed Central
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This article is from Behavioral and Brain Functions : BBF , volume 8 . Abstract Background: Studies suggest that older adults at risk of developing Alzheimer’s disease may show olfactory processing deficits before other signs of dementia appear. Methods: We studied 60 healthy non-demented individuals, half of whom were positive for the genetic risk factor the Apolipoprotein E ɛ4 allele, in three different age groups. Event-related potentials to visual and olfactory identification tasks were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542023
PubMed Central
by Roux, Veronique; El karkouri, Khalid; Lagier, Jean-Christophe; Robert, Catherine; Raoult, Didier
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This article is from Standards in Genomic Sciences , volume 7 . Abstract Kurthia massiliensis strain JC30T sp. nov. is the type strain of K. massiliensis sp. nov., a new species within the genus Kurthia. This strain, whose genome is described here, was isolated from the fecal flora of a healthy patient. K. massiliensis is a Gram-positive aerobic rod. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 3,199,090 bp long genome contains...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569394
PubMed Central
by Chardoli, Mojtaba; Khajavi, Alireza; Nouri, Mohsen; Rahimi-Movaghar, Vafa
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This article is from Journal of Injury and Violence Research , volume 4 . Abstract Background:: As a significant number of patients diagnosed with transient ischemic attack (TIA) at emergency department are at risk to develop TIA or cerebral vascular accident (CVA), several attempts have been made to figure out a predictive method to detect those at higher risk of such attacks. Therefore, the present study was aimed to evaluate the role of ABCD2 scoring including age, blood pressure, clinical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571586
PubMed Central
by Rehe, Klaus; Wilson, Kerrie; Bomken, Simon; Williamson, Daniel; Irving, Julie; den Boer, Monique L; Stanulla, Martin; Schrappe, Martin; Hall, Andrew G; Heidenreich, Olaf; Vormoor, Josef
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This article is from EMBO Molecular Medicine , volume 5 . Abstract Leukaemia-propagating cells are more frequent in high-risk acute B lymphoblastic leukaemia than in many malignancies that follow a hierarchical cancer stem cell model. It is unclear whether this characteristic can be more universally applied to patients from non-‘high-risk’ sub-groups and across a broad range of cellular immunophenotypes. Here, we demonstrate in a wide range of primary patient samples and patient samples...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569652
PubMed Central
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This article is from Sensors (Basel, Switzerland) , volume 13 . Abstract Perfumes are manufactured by mixing odorous materials with different volatilities. The parameter that measures the lasting property of a material when applied on the skin is called substantivity or tenacity. It is well known by perfumers that citrus and green notes are perceived as fresh and they tend to evaporate quickly, while odors most dissimilar to ‘fresh’ (e.g., oriental, powdery, erogenic and animalic scents)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574685
PubMed Central
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This article is from Oncology Letters , volume 5 . Abstract The aim of this study was to investigate the effects of different sequences of pulmonary artery and vein ligations during lobectomy on blood micrometastasis of non-small cell lung cancer (NSCLC). Cytokeratin 19 (CK19)/adhesion molecule CD44v6 mRNA were used as markers. A total of 30 NSCLC patients undergoing pulmonary lobectomy were randomly divided into pulmonary artery (PA)-first and pulmonary vein (PV)-first groups according to the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572991
PubMed Central
by Yumura, Shigehiko; Itoh, Go; Kikuta, Yumi; Kikuchi, Takeomi; Kitanishi-Yumura, Toshiko; Tsujioka, Masatsune
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This article is from Biology Open , volume 2 . Abstract Actin and myosin II play major roles in cell migration. Whereas pseudopod extension by actin polymerization has been intensively researched, less attention has been paid to how the rest of the actin cytoskeleton such as the actin cortex contributes to cell migration. In this study, cortical actin and myosin II filaments were simultaneously observed in migrating Dictyostelium cells under total internal reflection fluorescence microscopy....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575654
PubMed Central
by Gunther, Oliver P; Chen, Virginia; Freue, Gabriela Cohen; Balshaw, Robert F; Tebbutt, Scott J; Hollander, Zsuzsanna; Takhar, Mandeep; McMaster, W Robert; McManus, Bruce M; Keown, Paul A; Ng, Raymond T
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This article is from BMC Bioinformatics , volume 13 . Abstract Background: Biomarker panels derived separately from genomic and proteomic data and with a variety of computational methods have demonstrated promising classification performance in various diseases. An open question is how to create effective proteo-genomic panels. The framework of ensemble classifiers has been applied successfully in various analytical domains to combine classifiers so that the performance of the ensemble exceeds...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575305
PubMed Central
by SUZUKI, YOSHIHIRO; INOUE, TOSHIO; MURAI, MAYUMI; SUZUKI-KARASAKI, MIKI; OCHIAI, TOYOKO; RA, CHISEI
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This article is from International Journal of Oncology , volume 41 . Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, drugs that can amplify TRAIL cytotoxicity are urgently required. Depolarization of the plasma membrane potential is associated with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582902
PubMed Central
by HEO, CHANG-KYU; HWANG, HAI-MIN; RUEM, AH; YU, DAE-YEUL; LEE, JU YEON; YOO, JONG SHIN; KIM, IN GYU; YOO, HYANG SOOK; OH, SEJEONG; KO, JEONG HEON; CHO, EUN-WIE
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This article is from International Journal of Oncology , volume 42 . Abstract A novel circulating tumor-associated autoantibody, K94, obtained from a hepatocellular carcinoma (HCC) mouse model was characterized. The target antigen of K94 autoanti-body was expressed in various tumor cell lines including liver cancer, and its secretion was detectable using MCF-7 breast carcinoma cells. Proteomic analysis revealed that the protein bands reactive to K94 included cytokeratin (CK) 8 and 18, which are...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583721
PubMed Central
by Sluka, Kathleen A; Berkley, Karen J; O'Connor, Mary I; Nicolella, Daniel P; Enoka, Roger M; Boyan, Barbara D; Hart, David A; Resnick, Eileen; Kwoh, C Kent; Tosi, Laura L; Coutts, Richard D; Kohrt, Wendy M
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This article is from Biology of Sex Differences , volume 3 . Abstract People with osteoarthritis (OA) can have significant pain that interferes with function and quality of life. Women with knee OA have greater pain and greater reductions in function and quality of life than men. In many cases, OA pain is directly related to sensitization and activation of nociceptors in the injured joint and correlates with the degree of joint effusion and synovial thickening. In some patients, however, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583673
PubMed Central
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 68 . Abstract The title compound, [Hg5Br10(C7H8N2O)2]n, contains two μ3-bridging Br atoms, six μ2-bridging Br atoms and two terminal Br atoms. One HgII atom, lying on an inversion center, adopts a distorted octa­hedral geometry defined by six Br atoms. Two HgII atoms adopt a distorted square-pyramidal geometry by five Br atoms and the other two HgII atoms have a distorted tetra­hedral geometry by two N...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588746
PubMed Central
by Sager, Sait; Y?lmaz, Sabire; Ozhan, Meftune; Halac, Metin; Ergul, Nurhan; Ciftci, Hediye; Cermik, T. Fikret
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This article is from Molecular Imaging and Radionuclide Therapy , volume 21 . Abstract Vasculitis is defined as inflammation and necrosis with leukocytic infiltration of the blood vessel wall. Takayasu arteritis is a chronic inflammatory arteritis that primarily involves the aorta and its main branches. A 64-year-old female patient with a 2-month history of fever of unknown origin was presented to our clinic for F-18 FDG PET/CT imaging. Baseline PET/CT images demonstrated intense F-18 FDG...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590965
PubMed Central
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This article is from Cancers , volume 4 . Abstract For many thoracic malignancies, surgery, when feasible, is the preferred upfront modality for local control. However, adjuvant radiation plays an important role in minimizing the risk of locoregional recurrence. Tumors in the thoracic category include certain subgroups of non-small cell lung cancer (NSCLC) as well as thymic malignancies. The indications, radiation doses, and treatment fields vary amongst subtypes of thoracic tumors, as does the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712677
PubMed Central
by Lutfi, Riad; Lewkowich, Ian P; Zhou, Ping; Ledford, John R; Page, Kristen
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This article is from Journal of Inflammation (London, England) , volume 9 . Abstract Background: Serine proteases in German cockroach (GC) have been shown to mediate allergic airway inflammation through the activation of protease activated receptor (PAR)-2. Neutrophils play an important role in regulating the innate immune response, and are recruited into the airways following GC frass exposure. As such, we investigated the role of PAR-2 in airway neutrophil recruitment, activation and cytokine...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724482
PubMed Central
by Le Rouzic, Arnaud; Payen, Thibaut; Hua-Van, Aurelie
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This article is from Genome Biology and Evolution , volume 5 . Abstract The impact of transposable elements (TEs) on genome structure, plasticity, and evolution is still not well understood. The recent availability of complete genome sequences makes it possible to get new insights on the evolutionary dynamics of TEs from the phylogenetic analysis of their multiple copies in a wide range of species. However, this source of information is not always fully exploited. Here, we show how the history...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595040
PubMed Central
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This article is from Journal of Biomedical Research , volume 26 . Abstract EndoSheath bronchoscopy (Vision Sciences, Inc.) uses a sterile, disposable microbial barrier that may meet the growing needs for safe, efficient, and cost effective flexible bronchoscopy. The purpose of this open-label comparative study was to compare and calculate the costs-per-airway-procedure of the reusable fiberscope when used with and without EndoSheath® Technology; and to record the turnover time from the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596739
PubMed Central
by Chowdhury, Abdul Wadud; Hasan, ATM Hasibul; Kabir, SME Jahan; Sabah, KM Nurus
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This article is from BMC Research Notes , volume 5 . Abstract Background: Takayasu Arteritis is a vasculitis occurring mostly in young females which may present in diverse ways. Here we report a teenager with Takayasu Arteritis who presented with uncontrolled hypertension. This case depicts an atypical presentation of this disease where the girl visited many physicians for controlling the level of hypertension and put a diagnostic dilemma about the underlying etiology of young hypertension....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599449