live from london, this is bbc news. an iranian missile damages a hospital in the south of israel on the seventh day of the conflict. israel's prime minister says iran will pay a heavy price. iran says all options are on the table as president trump approves a plan to support israeli attacks. iran says this is a war of aggression, it has the right to defend itself, and has been threatening to target american military interests in the region if there is a direct american involvement. we will bring you all the latest developments from the region as they come in. also coming up... a blow for alzheimer's patients in the uk. two new patients

which can slow the disease are deemed too expensive for the nhs. a trial of the australian women accused of murdering relatives with toxic mushrooms is drawing to a close. the jury is expected to begin deliberations next week. we will have the very latest on the conflict between israel and iran, but first some developments that are just coming into us from the ground and gaza where the civil defence agency says 15 people who gathered near an aid distribution site in the centre of the territory had been shot dead by israeli forces. israel has yet to respond. the incident is the latest in almost daily shootings in your such sites since the controversial us and israeli backed gaza humanitarian foundation began operating and gaza last month. three other palestinians are said to have

been killed by israeli shelling near gaza city in the north. we will have more on that story when we get it. israel says at least 65 people were injured in the latest round of iranian strikes across the country. among the buildings hit on the seventh day of conflict was a hospital in the southern city of beersheba. israel says it's targeted iran's natanz nuclear in a tweet, benjamin netanyahu accused "terrorist tyrants" of launching missiles at the hospital and at a civilian population. he said israel would "exact the full price" from iran for the attack. iran says it was targeting a military site next to the hospital, not the hospital itself. they say they hit a military site and a blast wave damaged the hospital. a missile also landed between buildings in holon. a man in his 80s and two women in their 70s were said to

be in serious condition. they say they struck more than 20 military installations in tehran yesterday. they hit a heavy water nuclear reactor. the complex is commonly known as arak. it is understood around 60 israeli warplanes targeted iran last night. the attacks this morning come at a critical time. our correspondent is in holon, at the scene of one of the strikes. there's a wave of iranian missiles earlier today, air raid alerts sounded across the country at around 7:00 in the morning. the israeli authorities said around 30 missiles were fired by iran as iran continues to respond to these israeli airstrikes. most of those missiles were intercepted by the country's air defence systems, but some of them did manage

to penetrate the defences. and one of those missiles hit here, this residential neighbourhood in the city of holon, near tel aviv. and the authorities are saying that the missile landed between these two buildings here. you can see that the top section of that four-storey building partially collapsed. the authorities are saying that three people were injured as a result of the attack here. there is some damage in nearby buildings, houses, as well. so i think it shows that iran continues to have the ability to carry out these attacks. we've seen that the latest, you know, attacks by iran hadn't been as intense, which was seen as an indication of the impact of these israeli airstrikes on the iranian military's ability to carry out those attacks. and reflecting that, the israeli authorities yesterday announced that some of the restrictions that had been imposed because of the war were being eased. so, again, what we're seeing here today is that the iranian military continues to have the ability to carry out these missile attacks,

causing a lot of damage in places across israel. indeed. and of course, we're hearing more about the hospital, as well, that was struck, hugo. just tell us a little bit more about the hospital, where it is in relation to where you are and what more the authorities and medics have been telling us. yeah, rajini, so this is a hospital, the soroka medical centre, in the southern city of beersheba, about an hour's drive from here. and a missile struck this medical centre, medical facility. the iranian authorities are saying that the target of that attack was a military facility near this hospital. so we've had reaction from the israeli authorities accusing iran of deliberately targeting a hospital. we don't know, you know, what the target here could have been. but again, this was another, you know, missile that managed to penetrate the country's air defence systems.

now, the reaction that we're seeing from the israeli authorities so far indicate that these israeli airstrikes are going to intensify. the israeli defence minister says that not only military and nuclear facilities will be hit, but also government buildings, facilities linked to the iranian regime. so here, i think, you know, again, the strategy, as we've been discussing for days now, seems to be to put a lot of pressure on the iranian authorities, hinting at possible regime change in iran as a possible goal in this operation. indeed. benjamin netanyahu saying that iran will pay a heavy price. so, no sign that things are going to let up, hugo. no sign of de-escalation here. on the contrary. because now we're hearing from, you know, those reports in america that president trump has decided to go ahead with, has approved military plans for direct american involvement

in this israeli offensive, but no decision has been taken yet. a little bit of context here because it's crucial, because this is, you know, a very dangerous moment here in the middle east in which we could see a major regional escalation with american involvement. the israelis have been saying that this campaign is to destroy, damage iran's nuclear program. they've been saying that iran was getting close to the point of no return in developing a nuclear weapon. there hasn't been any evidence to support this, you know, this view. the assessment by the international community, including from the americans, is that the iranians had made no decision to weaponize their nuclear program. we don't know whether they had plans to do so, but the evidence on the ground was that no decision had been made. iran says this is a war of aggression, that it has the right to defend itself, and has been threatening to target american military interests in the region if there is direct american involvement.

and so we could see, you know, the potential here of a wider regional conflict. hugo bachega in holon. dan johnson is in jerusalem for us. we will talk about developments when it comes to those strikes between israel and iran in a moment, but i just wanted to briefly ask you about that developing news we are getting in from gaza where the civil defence agency is saying that a number of people who gathered at an aid distribution site were killed. i want if you could tell us any more that you know on that, please. -- i wondered if you could tell us any more. you'll macro the civil defence and gaza, run by hamas, said 15 people gathered near an aid distribution site have been shot by israeli forces. israel has not yet responded to that claim. there

is no information from the israelis. the civil defence and gaza say that 15 palestinians who were gathered at one of the sites that has been set up by the gaza humanitarian foundation, that is the us backed, israeli backed organisation that came into gaza two or three weeks ago now to take the place of organisations like the un in distributing aid. it is those sites that we have seen repeatedly palestinians having been shot by the israeli military almost daily for the last two weeks. there has been some sort of shooting incident at one of those aid distribution sites and palestinian lives have been lost. the agency is behind this say that it is because palestinians sometimes try to storm those sites in order to get hold of more aid than can be fairly distributed. these sites have been controversial, it has taken the place of international humanitarian organisations like the un that were struggling to distribute aid because of such a long period where aid supplies were

bought from gaza. we know there is desperate need among the gaza population, millions of people who are on the brink of starvation, who are hungry, who are desperate for that aid, but the idea of how desperate they are as visualised by the scenes that we have seen at some of these aid centres where people are ransacking and trying to get hold of more aid than can be fairly, evenly distributed. we are not sure of the circumstances of this incident this morning or even exactly when it happened, but it sounds like there has been more loss of palestinian life linked to those aid distribution centres. and just on that, the health authorities in gaza now saying that the number of palestinians killed since the 7th of october, 2023, has now risen to 55,000 637. the majority of whom are women and children. let's move on to the conflict between israel and iran. we heard from hugo bachega on the

ground in holon, the scene of one of the strikes, and we are also reporting on the hospital in beersheba which was hit. what more do we know about that? there was a wave of ballistic missiles in coming to israel early this morning from iran about 7am. here in jerusalem, the error rate siren and most of israel was affected -- might be air raid siren. that was on top of two waves that came last night and in the middle of the night. once again is the sound of air raid alerts, being told to take shelter. we heard the air defence interception to early this morning over jerusalem and other cities. it is being talked of as the most intense barrister has been in the last week of this conflict. certainly in jerusalem it was very loud and intense for a short time, just after 7am. in jerusalem, looks like the air defence systems were successful

in intercepting those missiles, but elsewhere at least seven strikes have been reported across the country, at least three in tel aviv, buildings have been damaged in the surrounding suburbs of tel aviv, and in the south of israel, in beersheba, that is where this hospital has been hit. the word that was affected most by the damage apparently had been mostly evacuated yesterday, but still there are reports of up to 50 people having been wounded there, the israelis are accusing the iranians of a war crime in targeting a civilian facility. the iranians have suggested they were aiming at some sort of military intelligence technology facility that was based nearby to that hospital. the israelis said the iranians had no business targeting a civilian hospital and they have called for retaliatory attacks on the power network in iran as a result of that. the defence minister has said iran's ayatollah will be held accountable for what has happened this morning, for the damage to israel's

infrastructure, the further damage to homes and buildings, and do we need to have been affected at that hospital. there are reports of 65 people across israel having been hurt this morning. and in terms of israeli attacks on iran, what is the latest on that? we know there was also action in the skies above iran last night, at least 50 israeli jets targeting one nuclear site, which israel ordered evacuations to the residents of that area yesterday. we know that there were strikes carried out and that seems to have been what prompted the iranian response that we saw overnight and then again this morning. israel is now promising further strikes on iran in retaliation for the hospital that has been hit this morning. it all underlines exactly what is at stake, what the risks are for both sides if this does escalate or if we do not get to some sort of negotiated peace deal quickly. whatever donald trump is deliberating, apparently having made the decision to support

israel and its further attacks on iran, but not having actually agreed to that yet, having taken some time to work out the timing. in the vacuum in the middle, both sides seem to have taken the opportunity to wrap things up, that is why we have seen more attacks, more damage, more casualties. the fear is that it will continue well there is no peace deal or the appearance of the us in terms of actively supporting those israeli strikes. it all seems to be now in donald trump as much chance as to what happens next and when. dan johnson in jerusalem, thank you very much for all of those updates. i have been speaking to the bbc's persian service in washington. he brought us up-to-date on any possible us involvement in the conflict. yellow macro there is a lot speculation about what president trump, when and what will be the final decision to be made by the president. he spoke about his options about

iran yesterday several times during the day. of course, he was also talking about if it is still a possibility, if there is still room for negotiations with iran. he said the iranians want to come to the white house and talk to him, but he has told them it is late and why didn't they negotiate earlier? but on the other side, iranians have said they have never asked for talks with president trump at the white house. actually, they said as long as the war carries on, there is no room for negotiations and they will only talk when the war stops. so we are waiting to see what the president's final decision is about whether the us would attack iran together with israel, hitting its nuclear installations, including the

fordo facility within the mountain. you have been monitoring iranian reaction, as well, so what have we been hearing from iran and indeed in the media there in response to what the white house is pondering? well, in the past 24 hours, iran has been dealing with cellular network outage and disruption, so there are some sort of blackout from what we have been receiving from inside iran. there has not been that much information on social media about what the situation is there. but from what we know is that the people are also waiting and speculating to see what happens with president trump's decision because that could be changing not only the situation inside iran, it could be having implications in the region because if the us joins

israel to attack iran, then the iranian regime may retaliate and hit, may try to hit us bases in the region. the leader of the islamic republic had a televised speech yesterday and he warned americans about the implications of joining the war and attacking iran, so there is a lot of anticipation. at the same time, the streets in a city like tehran, the capital, are almost empty. those who could have left the capital have left the capital, many cities, the major cities have been evacuated and not that many people are left on the streets. so the situation in iran is also that of a country that is under attack and people are waiting to see what happens next.

russia's president putin has said he's ready to meet president zelensky of ukraine, but only in the final phase of any peace negotiations. speaking at a news conference in st petersburg, the russian leader said any settlement to end his invasion of ukraine would need to prevent fighting - as he described it - from resuming in the long term. talks to broker peace in ukraine have stalled, as moscow continues its military bombardment and resists us-backed proposals for an unconditional truce. russian attacks on kyiv from monday into tuesday killed 26 people. translation: we don't care who leads the negotiations, even if it's the current head of the regime, i'm even ready to meet, but only if it is some kind of a final stage

so that we are not sitting there endlessly dividing something but putting a full stop. there must be a signature of a legitimate authority. here, two breakthrough alzheimer's drugs have been deemed too expensive for too little benefit to be offered on the nhs. the medicines are the first to slow the disease by clearing a build-up of protein in the brain. our health correspondent sophie hutchinson reports. do you remember we used to watch the ducks in there? yeah. mavis and her husband last year. she's taken part in a trial of a drug which is among the first to slow the progression of alzheimer's. and it's meant a great deal to them. i mean, she's still our mavis. she always was bright and cheery, and she still is. we've had some wonderful years since you came on this drug, haven't we? yeah. and some great times. yeah. and i'm grateful for it, too. my goodness! you know, it's making a difference to your life, isn't it?

the drug she's on is called lecanemab, but the health watchdog nice has said it and another similar drug, called donanemab, are too expensive for too little benefit - slowing mild alzheimer's for four to six months whilst requiring costly administering and monitoring in hospital. we're very disappointed that we haven't been able to recommend these medicines. of course, that disappointment will be felt much more keenly by people with dementia and cognitive impairment, and their families and carers. the reality is that nice's job is to balance the benefits of the medicine against the costs - the costs of the drug and the cost of administration, monitoring and so forth. so how expensive are the drugs? the official price in the us is £20,000 to £25,000 a patient a year. what the nhs would pay is confidential. around 70,000 people in england with mild dementia could be eligible - potentially putting a bill well above £1 billion a year. and that's before hospital scans and monitoring, which are also required.

the science is flying, but the system is failing. so even if these drugs were approved tomorrow, most people with dementia wouldn't be able to access them. and that's because, in order to access these drugs, you need to have a dementia diagnosis, and you need to be diagnosed at an early stage and have an accurate diagnosis. but currently, a third of people living with dementia don't have a diagnosis at all. and even those who do have a diagnosis, only 2% of those have access to the specialist diagnostic tests that you would need to access one of these new treatments. the two companies behind the drugs have expressed their disappointment, and said they intend to appeal the decision. sophie hutchinson, bbc news. the trial of the australian woman accused of murdering three of her relatives. and attempting to kill a fourth at a lunch where she served toxic mushrooms is drawing to a close. both the prosecution and defence have delivered their closing arguments in erin patterson's trial. the jury is expected to start deliberating next week. our australia correspondent

katy watson is in sydney and has been following the trial. the jury has heard from the witnesses. they've seen the evidence. and as you said, they've been listening to the closing arguments of both prosecution and defence. this is a trial that's now in its eighth week. it was meant to take five to six weeks. now, at the heart of the trial, the issue is not about how the relatives died. that much is clear. they died from toxic mushroom poisoning at a lunch that erin patterson served. the question is, and the prosecution alleges, that she intended to poison them, she wanted to kill them. her defence says this was a terrible accident. now, both sides have discussed the issue of a motive. the prosecution has said you don't need a motive to convict anybody of murder and put this to the jury. erin patterson's defence team has said that she didn't have a motive to kill her family, that she loved her in-laws, don and gail patterson,

and that much was clear. you know, throughout the trial, he talked about the fact that she had repeatedly said that she loved them. the other thing that came into under some scrutiny was the issue of lies that she made in the days after that lunch. the prosecution dissected her behaviour in the days after that lunch and the lies that she told the police and some of those lies she has admitted telling. the defence, though, say that was because she was panicked. she was worried about the implications. she realised the severity of what had happened. but her defence team also said that she put herself in the witness box. she answered questions and she came through unscathed. so those were the arguments that her defence team put. now the jury is expected to retire and deliberate sometime next week. hurricane erick has strengthened to an "extremely dangerous" category 4 storm, as it nears mexico's pacific coast. erick's maximum sustained winds have increased to nearly 145 mph - that's 230

kph - and the storm's centre is expected to make landfall in the states of oaxaca or guerrero on mexico's west coast. the us national hurricane centre says the storm is likely to bring "potentially destructive winds and life-threatening flash floods". mexico's president, claudia sheinbaum, has told people in the storm's path to "stay indoors, and not go out". a serial rapist will be sentenced today after being convicted in march of reaping ten women in the uk and china. the 28-year-old chinese foreign student who attended university college london tracked the women and filmed himself raping them. detectives fear he may have reaped as many as 50 women. -- you may have raped as many as 50 women. let's bring you some pictures from beersheba in southern israel where a hospital was hit after

iran launched a wave of missiles overnight. this is the hospital which has

this is bbc news. the headlines: an iranian missile damages a southern israel hospital on the seventh day of the conflict. israel's prime minister says iran will pay a "heavy price". university students in the uk i want to be shocked or offended as new freedom of speech laws come into force. nba side los angeles lakers are reportedly sold more than 10 billion dollars, the most expensive deal involving a us sports club. a jigsaw puzzle which took 2000 years to solve - archaeologists piece together a roman fresco found in london. and were at one of the most

fashionable sporting events of