The focus of this project was to develop synthetic methodologies and evaluate Titanium Nitride (TiN)-based nanomaterials, as prospective contrast agents for Photoacoustic (PA) Tomography, according to the following program: 1. Development of methodologies for preparation of stable nano-suspensions of TiN nanoparticles (TiN NPs) in physiological solution and plasma, by using natural and synthetic dispersants. 2. Development of methodologies for preparation of TiN NPs nano-suspensions based on modification of TiN NPs by molecules capable of binding to TiN NPs and having biological receptor-targeting moieties. 3. Testing stability of the receptor-targeted TiN NPs nano-suspensions in physiological solution and in plasma. 4. Evaluation of cell-binding capabilities of the receptor-targeted TiN NPs vs. non-targeted TiN NPs in relevant cellular models.