In the Federal Register of May 30, 1974, regulations were published as Part 46 of Title 45 of the Code of Federal Regulations providing generally for the protection of human subjects involved in research, development, or related activities supported by Department of Health, Education, and Welfare grants or contracts. This notice of proposed rulemaking is published to continue the public dialogue begun in November 1973, when the Director of the National Institutes of Health published draft proposals. These proposed rules cover minors, fetuses, abortuses, prisoners, and the institutionalized mentally disabled. (Author/JF)