The application of radioisotopes in medicine, industry, agriculture and research is the major activities that belong to the nuclear and radiological industries in Egypt. From a radiation safety and security of the sources standpoint, accident investigation is necessary to determine what happened, why, when and how it occurred and who were involved and be responsible. This paper aims to statistical evaluation of the reported accidents at “USIE” which is an “IAEA” web portal for contact point of state's members, in the period from Jun 2008 to March 2012. The study describes the major Nuclear or radiological (N/R) accidents that had happened during the above period, and provides a methodology for analysis, lessons learned and the associated hazards on the environment, workers and public health. This study will help the regulatory authority to review the reasons of vulnerabilities, and to start a radiation safety and security program to introduce measures capable to avoid the recurrence of similar events.