Orbital missions are considered which require the use of orbiting vehicles, e.g., a cislunar shuttle, that is either chemically or nuclear propelled, functioning as orbit-to-orbit shuttles combined with space tugs for servicing earth-orbiting payloads. Such vehicles may be stationed in a low earth orbit from which they would initiate and terminate flights. The flight frequency of these vehicles indicates that large quantities of propellants will have to be delivered to them in orbit. Orbiting propellant depots, in both geocentric and selenocentric orbits, are being considered as candidate methods of making the required propellants readily available. An assessment of the potential safety hazards associated with the operation of such a depot is summarized.