Most of the sound frequencies used in these recordings
correspond either to the molar mass or equivalent scalar
octave of the related products.

This work is dedicated to the public domain and

Algorithmic piano music mixed with sound frequencies.


* Aspirin-Vitamin C. Aspirin is an extremely versatile compound that helps to protect against heart disease and many different kinds of cancer, including colon, lung, breast, prostate, esophageal and even skin cancers. It can help prevent blood clots known as deep vein thromboses and is as good as warfarin in treating heart failure. Aspirin does have some serious risks, however, especially bleeding ulcers that could prove lethal. That is why people who take aspirin daily should make sure their physicians are aware of this practice.

* Berberine-Metformin when taken together, Metformin and berberine seem to work synergistically for even better glucose control. But diabetics are not the only people who could benefit from taking berberine. First, it improves muscle insulin sensitivity, and promotes blood glucose and fatty acid uptake into muscle cells.

* Bimatoprost is a medication used to treat high pressure inside the eye including glaucoma. Specifically it is used for open angle glaucoma when other agents are not sufficient. It may also be used to increase the size of the eyelashes.

* Buspirone is a human antidepressant drug. It has been shown to be effective in a significant number of cats with elimination (urination or defecation) disorders such as inappropriate urination, especially urine marking and other behavior problems. There is some evidence that buspirone on its own may be useful in the treatment of hypoactive sexual desire disorder (HSDD) in women.

* CH223191 significantly reduces obesity and adiposity and ameliorates liver steatosis in male C57Bl/6J mice fed a Western diet. The AHR with its broad ligand binding specificity is a promising candidate for a potentially simple therapeutic approach for the prevention and treatment of obesity and associated complications. ( Moyer, Benjamin J. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. United States: N. p., 2016. Web. doi:10.1016/J.TAAP.2016.03.011. )

* Collagen types 1 to 5. Collagen refers to a family of proteins that are the primary structural component of connective tissues, such as skin and cartilage. The substance makes up about a third of all the protein in the human body, more than any other type of protein in the body by mass. Collagen is responsible for several biological functions, one of which is to provide structural support in connective tissue, muscle, and skin. Collagen is the protein responsible for skin elasticity. It also plays a role in joint and bone health. Human bodies create collagen naturally. Over time, however, the production of this protein slows down.
Notes:
-The hydroxylase enzymes to synthetize collagen require vitamin C as a cofactor, a long-term deficiency in this vitamin results in impaired collagen synthesis and scurvy. These hydroxylation reactions are catalyzed by two different enzymes: prolyl-4-hydroxylase and lysyl-hydroxylase. Vitamin C also serves with them in inducing these reactions. In this service, one molecule of vitamin C is destroyed for each H replaced by OH.
-Hydroxyproline is a major component of the protein collagen, comprising roughly 13.5% of mammalian collagen. Hydroxyproline and proline play key roles for collagen stability.
-Use the recordings one at a time for a few days before going to the next.

-COL1A1, COL1A2, Hydroxyproline, ELN Elastin, Hydroxytyrosol

 * Type II: cartilage (main collagenous component of cartilage)
-Colagen 2A1, Hydroxyproline, Hydroxytyrosol

* Type III: reticulate (main component of reticular fibers), commonly found alongside type I
-COL3A1, Hydroxyproline, Hydroxytyrosol

* Type IV: forms basal lamina, the epithelium-secreted layer of the basement membrane
-COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, Hydroxyproline,
Hydroxytyrosol

* Type V: cell surfaces, hair, and placenta
-COL5A1, COL5A2, COL5A3, Hydroxyproline, Hydroxytyrosol

* CRL-40941 (also known as fladrafinil and fluorafinil) is a eugeroic closely related to adrafinil and modafinil. It is the bis(p-fluoro) ring-substituted derivative of adrafinil. CRL40941 promotes alertness, attention, wakefulness, positive mood, and other parameters, particularly in the elderly. It also may be used in depression and psychomotor retardation. CRL-40941 was found to produce antiaggressive effects in animals, which adrafinil does not produce.

* Deslorelin is used in veterinary medicine. The deslorelin products are used in veterinary medicine and to promote ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion. Deslorelin is also used to treat benign prostate hyperplasia in dogs.

* Dirlotapide is an effective pharmaceutical drug developed specifically for overweight and obese dogs to help them lose weight. This drug restrains the release of dietary fats from cells in the intestines into the bloodstream. That is done because the accumulation of fat in these intestinal cells leads to feelings of fullness and decreased appetite. Basically, Dirlotapide is used primarily as an appetite suppressant for dogs on a restricted calorie diet.

* DMB (3,3-Dimethyl-1-butanol) is a structural analog of choline. DMB is found in olive oil, red wine and other foods, has the potential to treat—or even prevent—heart disease. The investigators report that in mice, dietary supplementation with this naturally occurring compound safely inhibited atherosclerosis (plaque buildup in arteries) and significantly lowered production of TMAO (trimethylamine-N-oxide), a heart-harming metabolite derived from gut bacteria. DMB, may help reduce heart attack and stroke risk by altering the activity of gut microbes. Conversely, high intake of lecithin and L-carnitine has been linked to increased risk for atherosclerosis, also known as hardening of the arteries. Gut microbes convert these nutrients into a compound called trimethylamine (TMA), which in turn is converted into TMAO, which accelerates atherosclerosis in animals and is associated with a higher risk for heart disease in people.

* GV1001 is a peptide derived from the human telomerase reverse transcriptase (hTERT) sequence that is reported to have anti-cancer effects. It is also an anti-inflammatory that downregulates the production of pro-inflammatory cytokines through the suppression of p38 MAPK and NF-κB activation following ENO1 stimulation. It was developed as an anti-cancer agent to treat advanced pancreatic cancer, non-small lung cancer, melanoma, and other cancers. Recent studies have reported that GV1001 penetrates cell membranes by binding with heat shock proteins (HSPs) and accumulates in the cytoplasm. Additionally, this peptide protects against renal ischemia reperfusion injury (IRI) in mice by reducing acute inflammatory responses and decreasing the proportion of apoptotic cells that can cause renal injury. GV1001 possesses neuroprotective effects against Beta amyloid 25–35 oligomer in Neural Stem Cells and these effects are mediated through mimicking the extra-telomeric functions of human telomerase reverse transcriptase, including the induction of cellular proliferation, anti-apoptotic effects, mitochondrial stabilization, and anti-aging and anti-oxidant effects.

* Hydroxytyrosol is a type of phenolic phytochemical with antioxidant properties found in olive leaf and olive oil. Hydroxytyrosol has demonstrated an exceptional capacity for neutralizing free radicals and can be a powerful tool in the fight against oxidative stress and chronic disease. In a study, Hydroxytyrosol has been shown to double vitamin C levels in blood.

* Ibutamoren or MK-677  is a potent, long-acting, orally-active, selective, and non-peptide agonist of the
ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating
action of the endogenous hormone ghrelin. It has been shown to increase the secretion of several
hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the
plasma levels of these hormones without affecting cortisol levels. Ibutamoren has been shown to sustain
activation of the GH–IGF-1 axis and to increase lean body mass with no change in total fat mass or
visceral fat. It is under investigation as a potential treatment for reduced levels of these hormones, such
as in children or elderly adults with growth hormone deficiency, and human studies have shown it to
increase both muscle mass and bone mineral density, making it a promising potential therapy for the
treatment of  frailty in the elderly.

* Insulin Resistance-Diabetes Reversal. According to sources Adiponectin in combination with Leptin has

* Mecasermin rinfabate also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor 1 (IGF-1) and recombinant human insulin-like growth factor binding protein-3 (IGFBP-3) which is used for the treatment of amyotrophic lateral sclerosis (Lou Gehrig's disease). It is similar in action to mecasermin, but with fewer side effects (such as hypoglycemia). Treatment with rhIGF-I has been explored in a number of growth and endocrine disorders. The effects of Mecasermin rinfabate have been explored in a number of clinical situations including diabetes, severe insulin resistance, osteopaenia, burns and growth hormone insensitivity syndrome. For the treatment of IGF-I deficiency, it is desirable to administer IGF-I bound to IGFBP-3 to maintain the normal equilibrium of these proteins in the blood. Mecasermin rinfabate (rhIGF-I/rhIGFBP-3) mimics the effects of the natural protein complex in the bloodstream and would augment the natural supply of these linked compounds.
The most advanced indication in development of mecasermin rinfabate is the treatment of severe growth disorders due to growth hormone insensitivity syndrome (GHIS), also called Laron syndrome. GHIS is a genetic condition in which patients do not produce adequate quantities of IGF because of a failure to respond to the growth hormone signal. This results in a slower growth rate and short stature. Mecasermin rinfabate also has potential as replacement therapy for IGF-I, which may become depleted in indications such as major surgery, organ damage/failure, traumatic injury, cachexia and severe burn trauma. It also has potential for the treatment of osteoporosis.

* Mitochondrial support. The recordings include but are not limited to products:
Butyrate, Glutathione, Nicotinamide riboside, Creatine monohydrate, Acetyl-L-Carnitine, CoQ10
-Butyrate - for cellular health and mitochondria are clear
-Glutathione protect and support the mitochondria
- Nicotinamide riboside - converts into NAD+, which is said to have powerful mitochondrial effects that impact longevity and anti-aging
-Creatine monohydrate - to increase cellular ATP. More energy seems to indicate more ability to do “work” that leads to decreased fatigue, increased neuron growth, and drastically improved cognitive performance especially in vegans and vegetarians
-Acetyl-L-Carnitine - can support protecting mitochondria and preventing damage, but other evidence suggests it can help produce more energy when oxygen is scarce
- Acetyl-L-carnitine and CoQ10 - are essential molecules for producing energy in the body and promoting health of the mitochondria, known as the "powerhouse" of the cell. 

* Modafinil  is used for narcolepsy, shift work sleep disorder and obstructive sleep apnea/hypopnea. Modafinil enhances short-term memory allowing users to stay awake for long periods of time. It is sometimes used for performance enhancement by military pilots and soldiers during combat situations, and some now call it a "super drug". Its off-label uses have contributed to an ongoing debate on how far to push the human body through the use of drugs.

* Montelukast is used to prevent wheezing, difficulty breathing, chest tightness, and coughing caused by asthma in adults and children 12 months of age and older. Montelukast is also used to prevent bronchospasm (breathing difficulties) during exercise in adults and children 6 years of age and older. Montelukast is also used to treat the symptoms of seasonal (occurs only at certain times of the year), allergic rhinitis (a condition associated with sneezing and stuffy, runny or itchy nose) in adults and children 2 years of age and older, and perennial (occurs all year round) allergic rhinitis in adults and children 6 months of age and older. Montelukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It works by blocking the action of substances in the body that cause the symptoms of asthma and allergic rhinitis.

* NP213-fluoride. Novexatin (NP213) is an antifungal compound that has been proposed to function by destabilizing membranes, it is a circular hepta-arginine peptides. This is the first fungal infection therapy of the toenail to address both the underlying cause of the condition and the cosmetic issues associated with the infection; by rapidly killing the causative fungi and rapidly improving the nail’s appearance. Growth curves confirm that Novexatin has MIC values for fungi that are high relative to most commercial antifungal compounds. Fluoride has long been known to inhibit bacterial and fungal cell growth most likely by blocking the functions of key metabolic enzymes. Antifungal compounds that disrupt cell membrane integrity exhibit improved ability to inhibit cell growth when used with fluoride.

* Omega-3 fatty acids foster the development of brain circuitry and the speedy processing of information. They also play important roles in stabilizing mood and staving off cognitive decline. Low levels of omega-3s are linked to poor memory and depressive mood. Omega-3 fats are also critical for the formation of anti-inflammatory molecules in the body that protects against pain and disorders like arthritis and joint problems. Omega-3s might be involved: cardiovascular disease and its risk factors; infant health and neurodevelopment; cancer prevention; Alzheimer’s disease, dementia, and cognitive function; age-related macular degeneration; dry eye disease; rheumatoid arthritis; and other conditions. In pets, omega-3 fatty acids may also help to promote weight loss.

* Racetams-choline. Racetams are a class of drugs that share a pyrrolidone nucleus. Some, such as piracetam, are considered nootropics. Some such as aniracetam, oxiracetam, pramiracetam and phenylpiracetam are also nootropics. Racetams work in large part by modulating the release of acetylcholine, the neurotransmitter most closely associated with cognition. Racetams do not create more acetylcholine themselves, but they do stimulate acetylcholine receptor sites, which in turn stimulates the production of more of this crucial neurotransmitter. Choline is the precursor of acetylcholine, a crucial building block that’s absolutely necessary to its production. The recording includes a few nootropic racetams.

* Skin Enhance is a recording which features TT2 peptide, Hyaluronic acid and Peptamide 6.
-T2 showed positive and significant effects on signs of aging in two in vivo studies, including reducing the appearance of skin sagging and slacking, and improving firmness, elasticity and visco-elasticity in volunteers treated with the peptide formulation.
-Hyaluronic acid is a naturally occurring polysaccharide (carbohydrate) in the human body. It is present in large amounts in the spaces between skin cells, where it provides moisture, plumpness, firmness and suppleness to the skin.
-Peptamide 6 is a firming peptide that increases collagen synthesis and upregulates growth factors, transmembrane, matrix and heat shock proteins.

* Sodium Thiosulfate has a role as an antidote to cyanide poisoning, a nephroprotective agent an antifungal drug and hangover remedy. Sodium thiosulfate absorbs alcohol, preventing intoxication. The substance is used to cure alcoholism – long-term use of it makes a person develop an aversion to alcohol.

* SR1-UM729. SR1 StemRegenin is an Aryl hydrocarbon receptor (AHR) antagonist. It promotes ex vivo expansion of CD34+ human hematopoietic stem cells and the generation of CD34+ cells. UM729 367.443 enhances the self-renewal of human hematopoietic stem cells in vitro. UM729 does not inhibit the aryl hydrocarbon receptor (AHR) pathway, but has been shown to collaborate with AHR antagonists in preventing differentiation of acute myeloid leukemia (AML) cells in culture. UM279·enhances human hematopoietic stem cell self-renewal in vitro. According to cancer research, UM729 collaborates with StemRegenin 1 (SR1) in preventing differentiation of AML cells in culture.

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