Most of the sound frequencies used in these recordings
correspond either to the molar mass or equivalent scalar
octave of the related products.

This work is dedicated to the public domain and


Algorithmic piano music mixed with sound frequencies.


* ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of
evolutionarily-conserved proteins that share Bcl-2 Homology (BH) domains. First developed as a
potential cancer chemotherapy, it was subsequently identified as a senolytic (a drug that selectively
induces cell death in senescent cells). ABT-737 exhibits anticancer chemotherapeutic and
antithrombotic activities. ABT-737 is currently in clinical trials as one component of a combination
therapy in the treatment of various cancers such as acute myelogenous leukemia (AML). This
compound inhibits growth of AML cells in vitro and increases survival rates and lifespan in animal
models of AML. In vitro, ABT-737 induces mitochondrial membrane depolarization in platelets, inducing apoptosis and clearance.

* ACE-083 is a locally acting follistatin-based therapeutic that binds myostatin and other muscle
regulators and has been shown to increase muscle mass and force in neuromuscular disease mouse
models. In humans, ACE-083 was well tolerated and resulted in significant targeted muscle growth.
ACE-083 may have the potential to increase muscle mass in a wide range of neuromuscular disorders.

* ACT1 peptide is a new compound that could shield heart tissue before a heart attack, as well as
preserve healthy cells when administered after a heart attack. AlphaCT1, also has other unexpected
and beneficial effects, particularly in relation to skin wound healing -it helps reduce inflammation and
heal chronic wounds such as diabetic foot ulcers.

* Adenosine 5′-monophosphate disodium salt is clinically used for disseminated sclerosis, porphyria,
itching, liver disease, varicose ulcer complications. Compound eye drops containing mainly AMP can
be used for the corneal surface diseases of asthenopia, central retinitis,pannus and herpes. This
product can be used as nutrition enhancer. It can be added to the milk to increase the amount of
nucleotides ,make them closer to human milk ingredients ,so as to enhance infant’s resistance against
bacterial diseases.

* AH90 peptide is a potential wound healing-promoting peptide was identified from the frog skin of
Odorrana grahami. It showed potential wound healing-promoting activity in a murine model with full
thickness dermal wound. AH90 promoted release of transforming growth factor beta1 through
activation of nuclear factor-kappaB and c-Jun NH2-terminal kinase mitogen-activated protein kinases
signaling pathways, while inhibitors of nuclear factor-kappaB and c-Jun NH2-terminal kinase inhibited
the process. In addition, the effects of AH90 on Smads family proteins, key regulators in transforming
growth factor beta1 signaling pathways, could also be inhibited by transforming growth factor beta1
antibody. Altogether, this indicated that AH90 promoted wound healing by inducing the release of
transforming growth factor beta1.

* AS1842856. Excessive hepatic glucose production through the gluconeogenesis pathway is partially
responsible for the elevated glucose levels observed in patients with type 2 diabetes mellitus (T2DM).
The forkhead transcription factor Foxo1 plays a crucial role in mediating the effect of insulin on hepatic
gluconeogenesis. A Foxo1 inhibitor, an  orally  active  low-molecular  compound, as a therapeutic drug
for treating T2DM. AS1842856 potently inhibits human Foxo1 transactivation and reduces glucose
production through inhibition of G6Pase and PEPCK mRNA levels in a rat hepatic cell line. Oral
administration of AS1842856 to diabetic db/db mice led to a drastic decrease in fasting plasma
glucose level via inhibition of hepatic gluconeogenic genes, whereas administration to normal mice had  
no effect on fasting plasma glucose level. Treatment with AS1842856 also suppressed an increase in
plasma glucose level caused by pyruvate  njection in both normal and db/db mice. Taken together, these findings indicate that the Foxo1 inhibitor represents a new class of drugs for use in treating
T2DM. AS1842856 attenuates the development of asthmatic lung inflammation, it also induces a
significant decrease of tumor load in all critical organ compartments and increases the life span of the
animals when administrated at anti-diabetic concentrations.

* AXT107 is a new peptide which holds promise for improving treatment for degenerative retinal
diseases, such as age-related macular degeneration, diabetic macular edema and diabetic
retinopathy. These vascular diseases often result in central vision loss as blood vessels grow into
tissues at the back of the eye, where such growth should not occur.

* Berberine is an alkaloid from Hydrastis canadensis L. Berberidaceae. It is also found in many other
plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal
infections and as antidiarrheal. Berberine is an organic heteropentacyclic compound, an alkaloid
antibiotic, a botanical anti-fungal agent and a berberine alkaloid. It has a role as an antilipemic drug, a
hypoglycemic agent, an antioxidant, a potassium channel blocker, and antineoplastic agent.

* Bromantane is an atypical psychostimulant and anxiolytic drug of the adamantane family related to
amantadine and memantine which is used in Russia in the treatment of neurasthenia. Although the
effects of the bromantane have been determined to be dependent on the dopaminergic and possibly
serotonergic neurotransmitter systems, its exact mechanism of action is unknown, and it is distinct in its   properties relative to typical psychostimulants such as amphetamine. Because of its unique aspects,
bromantane has sometimes been described instead as an adaptogen and actoprotector. Asthenia is a
term used by the medical community to refer to weakness. It is a psychopathological condition
characterized by extreme acute or chronic loss of strength. This condition may lead to sleep disturbances, fatigue, or lack of energy as well as hyperesthesia, which is an extreme sensitivity of the
skin. Bromantane is described primarily as a mild psychostimulant and anxiolytic. It is also said to
possess antiasthenic properties. Bromantane is reported to improve physical and mental performance,  and hence could be considered a performance-enhancing drug.

* Caffeine and L-Theanine. The caffeine will help to promote alertness, attention and wakefulness, but
the L-theanine helps to mitigate many of the negative side effects of caffeine. More importantly, there
seems to be a synergy that allows you to focus on your tasks a lot better.

* CHCHD10 factor-related disorders include Frontotemporal dementia and/or amyotrophic lateral
sclerosis 2 (FTDALS2) is a neurodegenerative disorder with high intrafamilial variation with
phenotypes such as frontotemporal dementia and/or amyotrophic lateral sclerosis. Frontotemporal
dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis,
and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function.
Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem,
and spinal cord, resulting in fatal paralysis. Spinal muscular atrophy, Jokela type (SMAJ) is an
autosomal dominant, slowly progressive, lower motor neuron disease. SMAJ is characterized by adult-
onset of muscle cramps and fasciculations affecting the proximal and distal muscles of the upper and
lower limbs. The disorder results in weakness and mild muscle atrophy later in life. Myopathy, isolated
mitochondria l, autosomal dominant (IMMD) is a mitochondrial myopathy presenting with severe
exercise intolerance, progressive proximal weakness, and lactic acidemia. The disorder is slowly
progressive, with later involvement of facial muscles, muscles of the upper limbs, and distal muscles.
Mutations in CHCHD10 has also been found to be associated with cerebellar ataxia, frontotemporal
dementia (FTD), and other mitochondrial diseases.

* Chlorine dioxide is a relatively simple remedy to heal various diseases. Chlorine dioxide attacks
microbes and parasites. But it doesn’t go against the bacteria which we need for our own life. After the
input into our body no poisonous residues are left behind. Chlorine dioxide kills pathogens on food and
in the human body with oxygen. The only thing which is left over is a small amount of salt. Chlorine
dioxide is also applied to sterilize red blood cells. Doing this it was possible to kill several HIV-1 cells.
It can be used to cure almost any infectious disease including malaria, dengue, herpes, AIDs, and
more. Like ozone and chlorine, chlorine dioxide is an oxidizing biocide and not a metabolic toxin. This
means that chlorine dioxide kills microorganisms by disruption of the transport of nutrients across the
cell wall, not by disruption of a metabolic process. Chlorine dioxide is a molecule which is being
suggested for use against infections and cancer which are associated with microbes. This includes
melanoma, squamous cell carcinoma, and breast cancer.

* CRL-40940 or Flmodafinil is one of the newest nootropic supplements based on the popular
nootropic supplement, Modafinil. It has most of the same side effects and main effects associated with
Modafinil. It can be used when the point is in staying awake for a comparatively long period of time.
This is a supplement that really gives people a lot of energy, so it’s a good one for the people who are
planning on staying awake all night long. If they’re just after a short-term boost and they still want to be
able to go to sleep shortly afterward, than Flmodafinil might not be the best choice. This is going to
keep people awake for much longer than a few hours. Often times, people can’t really get themselves to  study or to complete a project well before the deadline because they have a difficult time pushing
themselves to work. This could be due to a general lack of energy, or it could be due to the fact that a
lot of people are suffering from emotional blocks that are preventing them from working. Taking
Flmodafinil manages to remove or diminish a lot of those emotional blocks, giving people significantly
more energy and allowing them to finish all of their projects.

* Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increases
insulin secretion by pancreatic Beta cells. Simultaneously the compound reduces the elevated
glucagon secretion by inhibiting alpha cells of the pancreas, which is known to be inappropriate in the
diabetic patient. GLP-1 is normally secreted by L cells of the gastrointestinal mucosa in response to a
meal. The compound is indicated for adults with type 2 diabetes mellitus as an adjunct to diet and
exercise to improve glycemic control. Dulaglutide is not indicated in the treatment of subjects with
type 1 diabetes mellitus or patients with diabetic ketoacidosis because these problems are the result
of the islet cells being unable to produce insulin and one of the actions of Dulaglutide is to stimulate
functioning islet cell to produce more insulin. Dulaglutide can be used either stand-alone or in
combination with other medicines for type 2 diabetes, in particular metformin, sulfonylureas,
thiazolidinediones, and insulin taken concomitantly with meals.

* H1a is a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Inhibition of
these channels using a “double-knot” spider venom peptide massively attenuates brain damage after
stroke and improves behavioral outcomes, even when the peptide is administered 8 h after stroke
onset. Intracerebroventricular administration to rats of a single small dose of H1a (2 ng/kg) up to 8 h
after stroke induction by occlusion of the middle cerebral artery markedly reduced infarct size, and this
correlated with improved neurological and motor function, as well as with preservation of neuronal
architecture. Inhibition of ASIC1a using H1a provides exceptional levels of neuroprotection even when
the peptide is administered up to 8 h after stroke onset. Along with facilitating a substantially reduced
level of penumbral damage. H1a is unique in providing some protection of the striatal core region,
which is generally considered therapeutically unrecoverable owing to rapid and irreversible necrotic
cell  death. Importantly, we have shown that the reduction in infarct volume in H1a-treated animals
translates to improved behavioral outcomes, with a marked decrease in neurological deficits and
motor impairment. We observed no adverse effects during the 72-h observation period following i.c.v.
administration of H1a, consistent with previous work showing that central or peripheral administration
of ASIC inhibitors does not produce unwanted side effects. Thus, H1a is a powerful pharmacological
tool for probing the role of ASIC1a in acid-mediated neuronal injury and various neurological disorders,
and a promising lead for the development of therapeutics to protect the brain from ischemic injury.

* Hydroxypyridinone is a molecule used in a type of therapy known as chelation, in which specific
molecules are used to remove heavy metals like mercury or, in this case, uranium from the
bloodstream. This particular chelating agent removed roughly 80 percent of the residual uranium in the
kidneys of exposed mice, while 50 percent of the residual radioactive material was extracted from the
animals’ bones, with minor adverse effects.

* Rutin helps the body utilize vitamin C and produce collagen (skin's main building blocks), can be used
to treat conditions such as hemorrhoids and high blood pressure (hypertension), and can also reduce
cholesterol levels. Rutin can be very helpful in treating strained blood vessels in such conditions as
hemorrhoids due to rutin's ability to maintain capillary flexibility and strength. The capillaries are the
smallest blood vessels in the body, and when they get strained in the anal region due to overweight or
pregnancy, having chronic diarrhea or constipation, or other reasons, the results are swollen blood
vessels, or hemorrhoids. Rutin is considered to be an antioxidant, meaning that it binds to damaging
free radicals in the body and neutralizes them. Free radicals turn LDL cholesterol into plaques, which in
turn can block arteries and prevent normal blood flow (a condition known as atherosclerosis). Blocked
arteries can lead to such cardiovascular conditions as hearth disease and stroke. Rutin can also be
used to treat Meniere's disease, a condition that causes ringing in the ears (tinnitus), dizziness and
intermittent hearing loss. Hydroxytyrosol has demonstrated an exceptional capacity for neutralizing free
radicals and can be a powerful tool in the fight against oxidative stress and chronic disease. In a study,
Hydroxytyrosol has been shown to double vitamin C levels in blood.

* Insect repellent frequencies mix consists of the molar masses of four chemicals, Thymol, Citral,
Citronellal, and Citronellol known for their pest-repellent, antiseptic, antibacterial, antifungal, and
vermifuge properties.

*  Magnoloside A ameliorates functional dyspepsia by modulating brain-gut peptides and gut
microbiota. It also exhibits potent antifungal activities against various Cryptococcus strains.

* Migraine, balance, vertigo. Erenumab-Galcanezumab-Fremanezumab are three antagonists of the
calcitonin gene-related peptide receptor (CGRPR) for the prevention of migraine. They are monoclonal
antibodies to block the receptors for the protein CGRP, thought to play a major role in starting migraines.

* MTHFR factor is a gene that holds the recipe for methylenetetrahydrofolate reductase – an enzyme
that helps our bodies convert vitamin B9 (also known as folate) into a usable form called methylfolate.
This process is called methylation. When the MTHFR gene is functioning properly, it’s highly efficient at
helping our bodies convert vitamin B9 (folate) into methylfolate. When the gene is mutated, this
capacity to convert vitamin B9 into methylfolate is reduced by 40-70%. That’s HUGE, because
converting folate into a useable form is essential for DNA synthesis and repair, neurotransmitter
production, detoxification, and immune function.

* Pandemic Viral Infection presents products related to viral epidemics.
3m
RNA Polymerase inhibitor - Favipiravir
NS3/4A Protease inhibitor - Simeprevir
RNA Synthesis inhibitor - Tarbavirin
3m
Reverse Transcriptase inhibitor - Racivir
Reverse Transcriptase inhibitor - Efavirenz
Reverse Transcriptase inhibitor - Tenofovir
3m
Entry inhibitor - VIR-576 peptide
NS5B inhibitor - Sofusbuvir
RSV Prevention - Palivizumab
3m
Antiviral - Galidesivir
Immunomodulator  - Alfacon-1
Monoclonal Antibody - Bavituximab
3m
Antiviral - Remdesivir
Antiretroviral Protease inhibitor - Saquinavir
Improved Saquinavir absorption - Omeprazole
3m
Antiretroviral - Lopinavir
Antiretroviral - Ritonavir
Protease inhibitor - Indinavir
3m
Antibiotic Immunosuppresive - Myriocin
Immunosuppressive - Mycophenolic acid
Immunosuppressive - Sirolimus

* Peptide 6 enhances neurogenesis in a mouse model of mild to moderate Traumatic Brain Injury.
Chronic administration of this molecule resulted in recovery of dendritic density and synaptic loss and
activation of the traditional tri-synaptic memory pathway in the hippocampus of injured mice. This also
resulted in improvement in memory on behavioral testing. The fact that this molecule is neurogenic and
is given peripherally and non-invasively demonstrates its potential in hippocampal regeneration in the
post-traumatic brain. Available data further emphasizes the role of neurotrophic factor supplementation
in TBI and makes a strong case for neurotrophic factor-based novel therapies for the injured
hippocampus.

* Ponericin-G1 peptide is derived from Pachycondyla goeldii ant venom. Presents broad antibacterial
and antifungal spectrum. Has marked insecticidal and non-hemolytic activities.

* PQQ-CoQ10. Pyrroquinoline quinone or PQQ is a synthetic molecule. There is some evidence in a
most compelling study that showed PQQ and CoQ10 could improve verbal memory performance
whereas either alone could not. PQQ and CoQ 10 promote antioxidant activity and mitochondrial health
through different mechanisms, providing multifunctional support for cardiovascular health and
neuroprotection. PQQ is an ideal complement to CoQ10 because PQQ stimulates the growth and
replication of those same mitochondria. More mitochondria with more spark means even more energy.

* RCGD423 activates a cellular signaling pathway called JAK-Stat, which transmits information from
outside the cell to the nucleus of the cell. The research showed that JAK-Stat activation leads to the
increased production of lactate and this in turn drives hair follicle stem cell activation and quicker hair
growth. RCGD423 also promotes cartilage growth while also stopping the inflammation that leads to
cartilage degeneration.

* SP-H5 is a bioactive peptide that coats tooth surfaces, helping prevent new cavities and heal existing
ones in lab experiments.

* Tiger17 peptide greatly diminished wound closure time in a full-thickness skin wound mouse model,
and the peptide was involved in three stages of wound-healing:
(i) the inflammatory stage, by recruiting macrophages to the wound site;
(ii) re-epithelialization and granulation tissue formation, by promoting proliferation and migration of both
keratinocytes and fibroblasts; and
(iii) the tissue remodeling phase, by activating mitogen-activated protein kinases signaling pathways
and by stimulating the release of interleukin 6 and transforming growth factor beta1 in murine
macrophages.
Altogether, these results clearly indicate Tiger17 as a promising wound-healing lead.

* UK5099 blocks pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice.

* ZXR-2 is a designed antimicrobial peptide represents a potential therapeutic for the prevention and
treatment of dental caries. Dental caries, a highly prevalent oral disease, is primarily caused by
pathogenic bacteria infection, and most of them are anaerobic. ZXR-2 showed broad-spectrum activity
against a variety of Gram-positive and Gram-negative oral bacteria, particularly the caries-related
taxa Streptococcus mutans. ZXR-2 killed most bacterial cells within 5 min at 4 × MIC. The mechanism
of ZXR-2 involved disruption of cell membranes, as observed by scanning electron microscopy.
Moreover, ZXR-2 inhibited the formation of S. mutans biofilm, but showed limited hemolytic effect.

plus-circle Add Review

comment

Reviews