Most of the sound frequencies used in these recordings
correspond either to the molar mass or equivalent scalar
octave of the related products.

This work is dedicated to the public domain and
may be reproduced without authorization.

Algorithmic piano music mixed with sound frequencies.


* 2-Mercaptoethanol. The drug disulfiram (see below) prevents the oxidation of acetaldehyde to acetic
acid and is used in the treatment of alcoholism. Disulfiram activity can be reversed by treatment with 2
mercaptoethanol, although not with glutathione. ALDH1 is strongly inhibited by disulfiram, while ALDH2
is resistant to its effect. The cysteine residue at 302 in ALDH1 and 200 in ALDH2 is implicated as a
disulfiram binding site on the enzyme and serves as a disfulfiram sensitive thiol site. Covalent binding
of disulfiram to the thiol blocks the binding of one of the cysteine residues with iodoacetamide, thereby
inactivating the enzyme and significantly lowering catalytic activity.

* Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne,
and is also used off-label to treat keratosis pilaris as well as other skin conditions. It is effective against
acne conditions where comedones are predominant. Adapalene has the unique ability to inhibit
keratinocyte differentiation and decrease keratin deposition. This property makes adapalene an
effective treatment for keratosis pilaris and callus. It may be used by men undergoing foreskin
restoration to reduce excess keratin that forms a layer on the exterior of the human penis after
circumcision. Other non-FDA approved indications that have been reported in the literature include
treatment of verruca vulgaris, molluscum contagiosum, Darier disease, photoaging, pigmentary
disorders, actinic keratoses and alopecia areata. A study has concluded that adapalene gel 0.1%
under occlusion is an effective, safe and easy to use treatment for plantar warts and may help clear
lesions faster than cryo-therapy.

* AGO4 factor encodes the protein argonaut 4. The protein is directly related to mammal cellular
sensitivity to viral infection. Mass General researchers have recently uncovered this novel potential
antiviral drug target that could lead to treatments protecting against a host of infectious diseases –
creating a universal treatment. Their work suggests that the protein Argonaute 4 (AGO4) is an “Achilles
heel” for viruses. Researchers suggest that boosting levels of AGO4 could shore up the immune system  
to protect against multiple viruses. When working with mice, the researchers found that only AGO4-
deficient cells were hypersensitive to infections, such as the influenza virus - more commonly known as
the flu.

* Ambroxol acts on mucus membranes, restoring the physiological clearance mechanisms of the
respiratory tract (which play an important role in the body’s natural defence mechanisms) through
several mechanisms, including breaking up phlegm, stimulating mucus production, and stimulating
synthesis and release of surfactant by type II pneumocytes. Surfactant acts as an anti-glue factor by
reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing
protection against infection and irritating agents. Ambroxol is a potent inhibitor of the neuronal Na+
channels. Many state-of-the-art clinical studies have demonstrated the efficacy of ambroxol in relieving
pain in acute sore throat, with a rapid onset of action, with its effect lasting at least three hours.
Ambroxol is also anti-inflammatory, reducing redness in a sore throat. Ambroxol has recently been
shown to increase activity of the lysosomal enzyme glucocerebrosidase. Because of this it may be a
useful therapeutic agent for both Gaucher disease and Parkinson's disease. It was also recently shown
that ambroxol triggers exocytosis of lysosomes by releasing calcium from acidic cellular calcium stores.
This occurs by diffusion of ambroxol into lysosomes and lysosomal pH neutralization.  This mechanism
is most likely responsible for the mucolytic effects of the drug, but may also explain the reported activity
in Gaucher and Parkinson's disease. Both ambroxol and its parent drug bromhexine have been shown
to induce autophagy in several cell types, and ambroxol was shown to potentiate rifampicin therapy in a
model of tuberculosis through host directed effects. Ambroxol also enhances lung levels of a wide
range of antibiotics.

* Azithromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes
middle ear infections, strep throat, pneumonia, traveler's diarrhea, furuncles and other intestinal
infections. It can also be used for a number of sexually transmitted infections, including chlamydia and
gonorrhea infections. Common side effects include nausea, vomiting, diarrhea and upset stomach.
Azithromycin is an azalide, a type of macrolide antibiotic. Azithromycin prevents bacteria from growing
by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thus
inhibiting translation of mRNA. Nucleic acid synthesis is not affected.

* Bemethyl is a synthetic actoprotector which is also antihypoxant (combating conditions of hypoxia),
antioxidant, and antimutagenic. Bemethyl is primarily classified as an actoprotector; a synthetic
adaptogen with significant capacity to increase physical performance. Bemethyl reduces anxiety, stress
and prevents fear; these properties improve performance in extreme conditions. People with asthenic
disorders (excessive fear, anxiety. and obsessive compulsions) and healthy adults alike can influence
their capacity for physical work.Bemethyl also has a positive effect on metabolic processes, allowing
adaptation to conditions causing frequent hypoxia, and the obtained effect is long-lasting and also
occurs after the end of dosage. Bemethyl has been shown to preserve both physical and mental
capacity in high-altitude, low-oxygen environments, particularly by its effect in helping control excess
serum levels of cholesterol and bilirubin, which are known to have negative effects especially during
adjustment to high-altitude environments. Bemethyl has also been shown to prevent permanent hearing loss and facilitate recovery of hearing after mine-explosion trauma, when treatment is initiated
immediately after injury. In one study, bemethyl was shown to prevent the mutagenic effect of white asbestos in mice and in cultured human whole blood. A study using mice showed bemethyl to reduce
mutatation induced by certain mutagenic drugs. Another study using cells from human donors showed
Bemethyl to be anticlastogenic (able to minimize chromosome breakages).

* Body Skin Cooling is a mix of cooling agents WS12, WS5 and L-Menthyl Lactate. Transient receptor
potential melastatin-8 (TRPM8), a cationic ion channel is involved in detection of normal cooling-
sensation in mammals. TRPM8 agonists act as cooling agents. TRPM8 activation by cooling or
chemical agonists have been shown to produce profound, mechanistically novel analgesia in chronic
pain states such as neuropathic pain in rodents. TRPM8 or a closely related protein in epidermal
keratinocytes plays a role in epidermal permeability barrier homoeostasis and epidermal proliferation
after barrier insult.

* Bupicomide is a chemical compound used experimentally as a beta blocker and clinically as a strong
vasodilator with the noted side effects of reduced systolic, diastolic and mean arterial pressure. As the
result of the screening program examining microbial fermentation products for pharmacological activity
(other than antibiotic activity), fusaric acid was isolated from Fusarium oxysporum following the
discovery that extracts were potent inhibitors of Dopamine beta-hydroxylase (DBH), and thus interfered
with the biosynthesis of the pressor neurohormone, norepinephrine. To refine this lead, amidation via
the acid chloride was carried out to give antihypertensive analog bupicomide.

* Bupropion is a medication primarily used to treat major depressive disorder and to support stopping
smoking. It is an effective antidepressant on its own, but is also used as an add-on medication in cases
of incomplete response to first-line SSRI antidepressants. Bupropion is taken in tablet form and is
available only by prescription in most countries. Common side effects include dry mouth, trouble
sleeping, agitation, and headaches. Serious side effects include an increased risk for epileptic
seizures and suicide. The risk of seizures caused the drug to be withdrawn from the market for some
time and then the recommended dose to be reduced. In comparison to some other antidepressants, it
does not cause as much sexual dysfunction or sleepiness, and may result in weight loss. It is unclear if
use during pregnancy or breastfeeding is safe. Bupropion is an atypical antidepressant. It acts as a
norepinephrine–dopamine reuptake inhibitor (NDRI) and a nicotinic receptor antagonist. Chemically,
bupropion is an aminoketone that belongs to the class of substituted cathinones and is similar to
phenethylamines.

* CCG-203971 reduces the migration of melanoma cells by 85 to 90%. The small-molecule drug
compound goes after a gene’s ability to produce RNA molecules and certain proteins in melanoma
tumors. This gene activity causes the disease to spread but the compound can shut it down. It is an
antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively
inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits
expression of CTGF, alpha-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFbeta-
stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo.
Also suppresses PC-3 cell migration in scratch wound assays.

* Cibinetide is an experimental drug developed to treat sarcoidosis induced small fiber neuropathy. It
also improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.

* CLP290 reactivates dormant nerves and, restores inhibition in injured spinal cord which leads to
functional recovery. CLP290 is known to activate a protein called KCC2, found in cell membranes,
which transports chloride out of neurons. After spinal cord injury, inhibitory neurons produce dramatically
less KCC2. As a result, investigators found, they can’t properly respond to inhibitory signals from the
brain. Instead, they respond only to excitatory signals that tell them to keep firing. And since these
neurons’ own signals are inhibitory, the result is too much inhibitory signaling in the local spinal circuit.
Bottom line: The brain’s commands telling the limbs to move aren’t relayed. By restoring KCC2, with
either CLP290 or genetic techniques, the inhibitory neurons can again process inhibitory signals from
the brain, so they fire less. This shifts the overall circuit back toward excitation, the researchers found,
making it more responsive to input from the brain. This had the effect of reanimating spinal circuits
disabled by the injury.

* Cogpep peptide. Cogpep targets the ABCA1 transporter that improves the apoE - ABCA1
cooperation. Cogpep helps prevent cognitive impairment, decrease tau hyperphosphorylation,
decrease neuronal amyloid Beta, increase (VGLUT1) and neurogenesis, increase ApoE receptor 2
(LRP8). It may also help in reducing the severity of Multiple Sclerosis, reverse arterial stiffness
assocated with Preeclampsia at late pregnancy and early postpartum and, as an anti-atherosclerotic.
ApoE4 is the strongest genetic risk factor for Alzheimer’s disease and is also over-represented in
many other dementias including Parkinson's dementia, fronto-temporal dementia and traumatic brain
injury suggesting a general metabolic culprit - lipid transport. ApoE4-driven dementia is found in
approximately 60% of Alzheimer's patients and more than 2.5 million patients in the USA alone. The
risk in apoE4 homozygote carriers is extra severe and increasing the likelihood to develop Alzheimer’s
disease 12-fold. Recent data shows that apoE4 compared to apoE2 and apoE3 has impaired
cooperation with its lipidation protein, the ATP Binding Cassette-A1 (ABCA1).

* Covid-19 Prevention, a natural compunds Mix for 2019-nCoV. 2019-nCoV, a novel coronavirus,
caused the pneumonia outbreak in China and continue to expand. The host receptor for 2019-nCoV
Angiotensin-converting enzyme 2 (ACE2), which is the same as the host receptor of SARS-CoV.
Targeting ACE2 holds the promise for preventing 2019-nCoV infection. Chinese Medicine herbs could
be a valuable pool for identifying active compounds for treating infection of 2019-nCoV. In this study, we
summarize several active compounds including Baicalin, Scutellarin, Hesperetin, Nicotinamine and
Glycyrrhizin that could have potential anti-2019-nCoV effects, and we conduct molecular docking to
predict their capacity for binding ACE2, which may subsequently prevent the 2019-nCoV infection. We propose that these selected compounds worth further investigation for preventing 2019-nCoV. (Chen,
H.; Du, Q. Potential Natural Compounds for Preventing 2019-nCoV Infection. Preprints 2020,
2020010358)

* Covid-19 Vaccine. Plitidepsin is a chemical compound extracted from the ascidian Aplidium
albicans. It is currently undergoing clinical trial testing as a Covid-19 vaccine. Plitidepsin is used and
approved for hematologic cancer in Australia, pending approval in New Zealand, Taiwan and South
Korea. Like all didemnin compounds, plitidepsin exhibits antitumor, antiviral and immunosuppressive
activities. It shows promise in shrinking tumors in pancreatic, stomach, bladder, prostate cancers, acute  
lymphoblastic leukemia and multiple myeloma.

* Cryosim-3 is novel TRPM8 agonist which relieves dry eye discomfort. C3 is a selective and potent
TRPM8 agonist without TRPV1 or TRPA1 activity. The dense neural network of the ocular surface,
especially of the cornea, generates the signs and symptoms of DED, namely, redness and tearing, and
irritation, itch, pain and dysesthesia such as feelings of grittiness, soreness, the presence of a foreign object, dryness, and eye fatigue. It is likely that TRPV1 transduces the signals of heat, irritation, and
pain from the ocular surface. The role of TRPM8 is multifaceted. TRPM8 may be associated with the
detection of “dryness” on the eye surface because it is activated by evaporative cooling and by
hyperosmolar solutions. TRPM8 may also be a direct stimulator of tear secretion from the lacrimal
gland.

* Dependency And Avoidance Of Withdrawal. Dopamine and Oxytocin are two neurochemicals that are
primary drivers underlying the trauma bond. Often when a person is traumatized by a romantic partner
or someone they love, these chemicals become significantly dysregulated. The recording plays the
sound frequencies of Bupicomide and L-368,889 to inhibit both Dopamine and Oxytocin.  L-368,899 is
a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with
good selectivity over the related vasopressin receptors. The centrally mediated roles of oxytocin, such
as in social behaviour and pair bonding, and studies in primates have shown L-368,899 to reduce a
number of behaviors such as food sharing, sexual activity and caring for infants, demonstrating the
importance of oxytocinergic signalling in mediating these important social behaviors. Bupicomide is a
fusaric acid analog, potent inhibitors of Dopamine beta-hydroxylase (DBH), and thus interfered with the
biosynthesis of the pressor neurohormone, norepinephrine.

* Desquamation in healthy skin is an invisible process and the stratum corneum is turned over
completely within 2–4 weeks, while maintaining the tissue thickness. This process is a normal
protective mechanism of the skin to prevent pathogens from colonizing the skin, and is referred to as
desquamation. The overall integrity of the stratum corneum is maintained by specialized intercellular
proteins called corneodesmosomes. The components of the corneodesmosomes are gradually
degraded by the enzymes that digest proteins, as the corneocytes are pushed towards the surface of
the skin. As a result of the weakened corneodesmosomes in the outer skin surface, the uppermost
layers of corneocytes get exfoliated through frictional forces such as rubbing or washing. Expression of
corneodesmosomes and, notably, the process of their degradation are probably altered during several
dermatoses leading to the disruption of the permeability barrier or to abnormal, often compensative,
Stratum Corneum accumulation. The recording includes the three adhesive proteins desmoglein-1,
desmocollin-1 and corneodesmosin which compose the corneodesmosomes and provide the cohesive      
forces to connect the adjacent corneocytes, Mifepristone a Glucocorticoid receptor antagonist, LEKTI
factor which regulates desquamation, FLG factor and, Apigenin.

* Disulfiram is a drug used to support the treatment of chronic alcoholism by producing an acute
sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde
dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol
consumption. Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and
neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain,
palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness,
weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory
depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive heart
failure, unconsciousness, convulsions, and death. Disulfiram should be used in conjunction with
counseling and support (see 2-Mercaptoethanol above.) An alternate use of disulfiram can eradicate all
forms borrelia can take. Disulfiram also has anticancer and antifungal properties, it belongs to a
general group of HIV drugs called latency-reversing agents, and it is effective against parasites such as
malaria and babesia. Recent experience with disulfiram, shows efficacy against bartonella. A clinical
study on a small group of chronic Lyme patients reports these patients have become asymptomatic (if
not cured) for 21 months.

* Emoxypine is an antioxidant whose chemical structure resembles that of pyridoxine (a type of vitamin
B6). Emoxypine has a wide range of applications in medical practice. It purportedly exercises
anxiolytic, anti-stress, anti-alcohol, anticonvulsant, nootropic, neuroprotective and anti-inflammatory
action. Emoxypine presumably improves cerebral blood circulation, inhibits thrombocyte aggregation,
lowers cholesterol levels, has cardioprotective and antiatherosclerotic action. One study determined the
effectiveness of emoxypine in 205 patients with clinical manifestations of lumbosacral radiculopathy
(LSR).

* Halicin is a drug which acts as an inhibitor of the enzyme c-Jun N-terminal kinase (JNK). Halicin was
identified by researchers at MIT in 2019 using an in silico deep learning approach, as a likely broad-
spectrum antibiotic. This was subsequently verified by in vitro cell culture testing followed by in vivo tests
in mice. It showed activity against drug-resistant strains of Clostridium difficile, Acinetobacter
baumannii, and Mycobacterium tuberculosis, with an unusual mechanism of action involving the
sequestration of iron inside the bacterial cells which thereby interferes with their ability to properly
regulate the pH balance across the cell membrane. Since this is a different mode of action from most
antibiotics, halicin retained activity against bacterial strains resistant to many commonly used drugs.

* Heat Rash Mix plays the sound frequencies of salicylic acid, cetrimide, menthol, and acetone.

* Irritable Male Syndrome (IMS) can be defined as a state of hypersensitivity, frustration, anxiety, and
anger that occurs in males and is associated with biochemical changes, hormonal fluctuations, stress,
and loss of male identity. Even though Irritable Male syndrome is in most cases affected by stress that
is high and/or low testosterone; high levels of estrogen may also cause men to be irritable. The major
source of this imbalance is a level of testosterone that is declining associated with andropause and
aging. Other issues may add to the andropause-related swing of moods in male such as gaining of
weight. This generates fat cells that create estrogen from testosterone. The greater the level of estrogen
and the lower the levels of testosterone the larger is the probability of irritability in males. Additionally,
high levels of the hormone for stress cortisol reduce testosterone levels, triggering the increased
likelihood of swinging of moods in men. Certain drugs can also cause imbalances of hormones. The
recording plays the sound frequency of testosterone.

* Lanthionine ketimine is a naturally occurring sulfur amino acid metabolite found in the mammalian
brain and central nervous system (CNS). Beside its neurotrophic effects, lanthionine ketimine and its
ester LKE protect neurons against oxidative stress and inhibit the activation of microglia (brain
macrophages) triggered by exposure to inflammatory cytokines. Beside its neurotrophic effects,
lanthionine ketimine and its ester LKE protect neurons against oxidative stress and inhibit the activation
of microglia (brain macrophages) triggered by exposure to inflammatory cytokines. Lanthionine
ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and
promoting axon growth 1. Lanthionine ketimine and its synthetic derivatives have recently demonstrated
neurotrophic, neuroprotective, and antineuroinflammatory properties.

* Norepinephrine, also called noradrenaline (NA) or noradrenalin, is an organic chemical in the
catecholamine family that functions in the brain and body as a hormone and neurotransmitter. The
general function of norepinephrine is to mobilize the brain and body for action. Norepinephrine release
is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of
stress or danger, in the so-called fight-or-flight response. In the brain, norepinephrine increases arousal
and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention;
it also increases restlessness and anxiety. In the rest of the body, norepinephrine increases heart rate
and blood pressure, triggers the release of glucose from energy stores, increases blood flow to skeletal
muscle, reduces blood flow to the gastrointestinal system, and inhibits voiding of the bladder and
gastrointestinal motility. Many important psychiatric drugs exert strong effects on noradrenaline systems
in the brain, resulting in side-effects that may be helpful or harmful. Norepinephrine is similar to
adrenaline. It is used to treat life-threatening low blood pressure (hypotension) that can occur with
certain medical conditions or surgical procedures. Norepinephrine is often used during CPR (cardio-
pulmonary resuscitation).

* Skin Homeostasis plays the sound frequencies of Y27632 and Apocynin. The protein Collagen Type-
17A1 has been noted by scientists as beneficial to keep skin “intact and unimpaired” through the
process of cell competition. COL17A1 encourages cell competition by driving out weak cells and
revitalizing stronger cells toward replication, and in the process, maintaining tissue fitness. The two
compounds with the ability to “kick-start” the antiaging process, Y27632 and apocynin, produced
positive results on skin cells via skin regeneration and reducing skin aging. They "significantly
promoted" repair and regeneration even to deep-tissue skin wounds, and it was done two ways,
according to the study, published in the journal Nature. Stem cells with higher potential or quality are
thus selected for homeostasis, but their eventual loss of COL17A1 limits their competition, thereby
causing ageing. The resultant hemidesmosome fragility and stem cell delamination deplete adjacent
melanocytes and fibroblasts to promote skin ageing. Conversely, the forced maintenance of COL17A1
rescues skin organ ageing, thereby indicating potential angles for anti-ageing therapeutic intervention.

* Skin Moisture. The recording plays the sound frequency of Sodium lactate, Allantoin, Palmitoleic acid,
Lactic acid, Glycerin and, Urea.
-Sodium lactate is a food additive and an effective humectant and moisturizer.
-Allantoin has a moisturizing and keratolytic effect, increasing the water content of the extracellular
matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness
of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin
protectant effect by forming complexes with irritant and sensitizing agents.
-Palmitoleic acid or Omega-7 is a common constituent of the glycerides of human adipose tissue. It
promotes healthy and moisturized skin, hair, and nails at a cellular level, supports also a healthy
gastrointestinal and digestive system from start to finish.  
-Lactic acid is used in topical preparations and cosmetics to adjust acidity and for its disinfectant and
keratolytic properties.
-Glycerin is used in medical, pharmaceutical and personal care preparations, often as a means of
improving smoothness, providing lubrication, and as a humectant. Ichthyosis and xerosis have been
relieved by the topical use glycerin.
-Urea is used as a cream for ichthyosis and other hyperkeratotic skin disorders.

* Testosterone and Growth Hormone. During human puberty there is a substantial increase in growth
hormone (GH) and sex steroidal hormone concentrations, as well as in GH production rates and insulin-
like growth factor-I (IGF-I). The nonoxidative leucine disposal (NOLD), a measure of whole body protein
synthesis, increased significantly after combined T/GH. The combination of T/GH also resulted in
greater changes in body composition than T alone, with comparable decreases in %FM and
corresponding increases in fat free mass (FFM). Measures of carbohydrate (CHO) metabolism,
including glucose production and oxidation rates, were unaffected by either T or T/GH combination.
Plasma IGF-I concentrations increased after T treatment and even more after T/GH combination. In
conclusion GH and T are synergistic on whole body protein anabolism and body composition in males,
even at a young age, but the positive effects of T on protein anabolism and body composition appear to
need a basal amount of GH for those effects to be observed. GH and T both potentiate the
development of the full body composition and metabolic changes of puberty.

* TIK-301 is an agonist for the melatonin receptors MT1 and MT2 that is under development for the
treatment of insomnia and other sleep disorders. Its agonist action on MT1 and MT2 receptors in the
suprachiasmatic nucleus in the brain enables its action as a chronobiotic. Studies show that it is more
potent and more effective than melatonin.TIK-301's action on MT1 and MT2 receptors contributes to its
sleep-promoting effects because melatonin's effects at these same receptors is linked with
maintenance of normal-sleep wake cycle. Compared to melatonin, it has nine times greater
bioavailability and six times greater area under the curve (AUC), which means the body retains more of
an administered dose.TIK-301 is intended to be a take-as-need drug for primary insomnia, circadian
rhythm disorders, depression, as well as sleep disorders in blind individuals and can be used to
alleviate neuroleptic-induced tardive dyskinesia in schizophrenia patients. In addition to a sleep aid,
TIK-301 has been found useful in treating other disorders. Because of its affinity for serotonin receptors,
it has potential to serve as a possible antidepressant drug, similar to agomelatine. TIK-301 has also
been considered for use in patients with mild cognitive impairment (MCI) because of sleep disorder
prevalence.

* XIB-4035 is a therapeutic candidate for small-fiber neuropathy, a type of peripheral neuropathy that
occurs from damage to the small unmyelinated peripheral nerve fibers. These fibers, are present in
skin, peripheral nerves, and organs. The role of these nerves is to innervate the skin (somatic fibers)
and help control autonomic function (autonomic fibers). XIB-4035 is a GRF-Alpha1 receptor enhancer
compound. This nonpeptidyl small molecule is capable of inducing activation of a receptor that normally
bind a relatively large protein ligand such as GDNF. In experiments with XIB-4035 mice showed
improvements in nerve structure and regained sensitivity to heat compared with controls. Sensation
improved in both diabetic mice and mice that developed small-fiber neuropathy through genetic
manipulation. Even mice with advanced disease showed improvements.

plus-circle Add Review

comment

Reviews