17 pages. (December 2022). The relationship between homelessness and drug use is complex, with marked variations in the prevalence of high-risk drug use across groups of people who experience homelessness. This miniguide provides an overview of the most important aspects to consider when planning or delivering health and social responses for people experiencing homelessness and using drugs and reviews the availability and effectiveness of the responses. It also considers implications for policy and practice. Contents: overview, key issues, evidence and responses, European picture, implications for policy and practice.