A changing climate may alter the expected patterns of infectious disease emergence in North America, requiring nurse practitioners to become familiar with these changes in infectious disease emergence in their local communities. This report reviews how potential climate change might affect seasonal patterns of infectious diseases, including the impact on the agents that cause them and alterations in host behaviors/the environment that may modify the pattern of infectious diseases locally. This knowledge base will aid nurse practitioners in making accurate diagnosis/treatment plans for diseases they may not be familiar with currently.