51
51
Oct 14, 2014
10/14
by
Bartkowska-Sniatkowska, Alicja; Rosada-Kurasinska, Jowita; Ignys, Iwona; Grzeskowiak, Malgorzata; Zielinska, Marzena; Bienert, Agnieszka
texts
eye 51
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This article is from Przegla̜d Gastroenterologiczny , volume 9 . Abstract Endoscopic procedures of the gastrointestinal tract were successfully introduced into paediatric practice in the 1970s. Recent expansive development has become useful for improvement of both diagnosis and treatment in many children with gastrointestinal diseases. Most of these procedures are performed under procedural sedation (PSA) knowing anatomical, physiological and psychological differences and requiring good...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108748
86
86
Oct 7, 2014
10/14
by
Gao, Xiaoyan; Li, Xiaolong; Li, Minghua; Fu, Shihong; Wang, Huanyu; Lu, Zhi; Cao, Yuxi; He, Ying; Zhu, Wuyang; Zhang, Tingting; Gould, Ernest A.; Liang, Guodong
texts
eye 86
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This article is from PLoS Neglected Tropical Diseases , volume 8 . Abstract Japanese encephalitis (JE) is arguably one of the most serious viral encephalitis diseases worldwide. China has a long history of high prevalence of Japanese encephalitis, with thousands of cases reported annually and incidence rates often exceeding 15/100,000. In global terms, the scale of outbreaks and high incidence of these pandemics has almost been unique, placing a heavy burden on the Chinese health authorities....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133196
58
58
Oct 28, 2014
10/14
by
Ghenghesh, Khalifa Sifaw; Rahouma, Amal; Tawil, Khaled; Zorgani, Abdulaziz; Franka, Ezzedin
texts
eye 58
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This article is from The Libyan Journal of Medicine , volume 8 . Abstract Resistance to antimicrobial agents is a major health problem that affects the whole world. Providing information on the past state of antimicrobial resistance in Libya may assist the health authorities in addressing the problem more effectively in the future. Information was obtained mainly from Highwire Press (including PubMed) search for the period 1970–2011 using the terms ‘antibiotic resistance in Libya’,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610430
Mendeley Climate Change Library
44
44
Jul 6, 2019
07/19
by
Hanxiao Zhang; Shouliang Huo; Kevin M. Yeager; Zhuoshi He; Beidou Xi; Chunzi Ma; Fengchang Wu
texts
eye 44
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Studies that address the potential effects of climate and anthropogenic activities on lacustrine phytoplankton succession are scarce in the shallow lakes. In the present work, the succession of phytoplankton community inferred from sedimentary pigments has been investigated; the impacts of climate and anthropogenic activities on the succession have been evaluated by the generalized additive models (GAMs) in a shallow eutrophied lake, Lake Chaohu, located eastern China. The results show that...
Topics: Algae succession, Anthropogenic activities, Climate change, Generalized additive models,...
156
156
May 1, 2012
05/12
by
Hoge, James F; Zakaria, Fareed
texts
eye 156
favorite 6
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Includes bibliographical references and index
Topics: World politics, Politique mondiale, Diplomatic relations
43
43
Oct 22, 2014
10/14
by
Jean-Richard, Vreni; Crump, Lisa; Abicho, Abbani Alhadj; Nare, Ngandolo Bongo; Greter, Helena; Hattendorf, Jan; Schelling, Esther; Zinsstag, Jakob
texts
eye 43
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This article is from BMC Veterinary Research , volume 10 . Abstract Background: Fasciolosis has been described in sub-Saharan Africa in many accounts, but the latest reports from Chad are from the 1970s. Mobile pastoralists perceive liver parasites as a significant problem and think that proximity to Lake Chad can lead to infection. This study aimed to assess the importance of liver fluke infections in mobile pastoralists’ livestock in the south-eastern Lake Chad region.In 2011, all animals...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022263
4
4.0
Jun 30, 2018
06/18
by
Jilong Chen; Zhaopeng Sun; Juan Zhao; Yujun Zheng
texts
eye 4
favorite 0
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Whether natural factors could interpret the rise of the Earth's surface temperature is still controversial. Though numerous recent researches have reported apparent correlations between solar activity and the Earth's climate, solar activity has encountered a big problem when describing the rapid global warming after 1970s. Our investigation shows the good positive correlations between the Earth's surface Ultraviolet irradiance (280-400 nm) and the Earth's surface temperature both in temporal...
Topics: Physics, Earth and Planetary Astrophysics, Atmospheric and Oceanic Physics, Astrophysics
Source: http://arxiv.org/abs/1411.6511
4
4.0
Jun 29, 2018
06/18
by
Mohamed A. Alrshah; Mohamed Othman; Borhanuddin Ali; Zurina Mohd Hanapia
texts
eye 4
favorite 0
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Transmission Control Protocol (TCP) has been profusely used by most of internet applications. Since 1970s, several TCP variants have been developed in order to cope with the fast increasing of network capacities especially in high Bandwidth Delay Product (high-BDP) networks. In these TCP variants, several approaches have been used, some of these approaches have the ability to estimate available bandwidths and some react based on network loss and/or delay changes. This variety of the used...
Topics: Networking and Internet Architecture, Computing Research Repository
Source: http://arxiv.org/abs/1610.03534
3
3.0
Jun 30, 2018
06/18
by
Márton Elekes; Zoltán Vidnyánszky
texts
eye 3
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In the 1970s M. Laczkovich posed the following problem: Let $\mathcal{B}_1(X)$ denote the set of Baire class $1$ functions defined on an uncountable Polish space $X$ equipped with the pointwise ordering. \[\text{Characterize the order types of the linearly ordered subsets of $\mathcal{B}_1(X)$.} \]The main result of the present paper is a complete solution to this problem. We prove that a linear order is isomorphic to a linearly ordered family of Baire class $1$ functions iff it is isomorphic...
Topics: Mathematics, Logic
Source: http://arxiv.org/abs/1410.8362
73
73
Oct 27, 2014
10/14
by
O'Brien, Heath E; Thakur, Shalabh; Gong, Yunchen; Fung, Pauline; Zhang, Jianfeng; Yuan, Lijie; Wang, Pauline W; Yong, Choseung; Scortichini, Marco; Guttman, David S
texts
eye 73
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This article is from BMC Microbiology , volume 12 . Abstract Background: Hazelnut (Corylus avellana) decline disease in Greece and Italy is caused by the convergent evolution of two distantly related lineages of Pseudomonas syringae pv. avellanae (Pav). We sequenced the genomes of three Pav isolates to determine if their convergent virulence phenotype had a common genetic basis due to either genetic exchange between lineages or parallel evolution. Results: We found little evidence for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411506
43
43
Oct 24, 2014
10/14
by
Pan, Duo; Song, Yan-Ling; Zeng, Zhi-Gao; Bravery, Benjamin D.
texts
eye 43
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This article is from PLoS ONE , volume 9 . Abstract An emerging issue in wildlife conservation is the re-establishment of viable populations of endangered species in suitable habitats. Here, we studied habitat selection by a population of Hainan Eld’s deer (Cervus eldi) relocated to a patchy landscape of farmland and forest. Hainan Eld’s deer were pushed to the brink of extinction in the 1970s, but their population expanded rapidly from 26 to more than 1000 individuals by 2003 through...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948744
California Digital Library
2,599
2.6K
Sep 26, 2006
09/06
by
Riasanovsky, Nicholas Valentine, 1923- ive; Bancroft Library. Regional Oral History Office; Zelnik, Reginald E; Lage, Ann
texts
eye 2,599
favorite 1
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1 v. (x, 310 p.) : 28 cm
Topics: University of California, Berkeley. Dept. of History, Russkaia pravoslavnaia tserkov, University of...
65
65
Oct 17, 2014
10/14
by
Schmitz, Daniela; Zapp, Josef; Bernhardt, Rita
texts
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This article is from Microbial Cell Factories , volume 13 . Abstract Background: Steroids are lipophilic compounds with a gonane skeleton and play an important role in higher organisms. Due to different functionalizations - mainly hydroxylations - at the steroid molecule, they vary highly in their mode of action. The pharmaceutical industry is, therefore, interested in hydroxysteroids as therapeutic agents. The insertion of hydroxyl groups into a steroid core, however, is hardly accomplishable...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080778
Mendeley Climate Change Library
55
55
Jul 6, 2019
07/19
by
Shuyang Ma; Yang Liu; Jianchao Li; Caihong Fu; Zhenjiang Ye; Peng Sun; Haiqing Yu; Jiahua Cheng; Yongjun Tian
texts
eye 55
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Located at the margin of the Northwest Pacific Ocean, the Yellow Sea (YS) and East China Sea (ECS) marine ecosystems are mainly influenced by the Kuroshio and its branches. In addition to decadal changes in their marine environments, the YS and ECS have been impacted by intensive fishing at both the species- and community-levels, leading to over-exploitation of commercial species and changes in species composition and trophic structure. The dual effects of overfishing and climate change on the...
Topics: Biotic community, Chinese waters, Climatic changes, Ecosystems, Long-term changes, Regime shifts
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56
Oct 28, 2014
10/14
by
Song, Conghe; Lord, Jackson W.; Zhou, Liming; Xiao, Jingfeng
texts
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This article is from Sensors (Basel, Switzerland) , volume 8 . Abstract Migration is one of the major socio-economic characteristics of China since the country adopted the policy of economic reform in late 1970s. Many studies have been dedicated to understand why and how people move, and the consequences of their welfare. The purpose of this study is to investigate the environmental impacts of the large scale movement of population in China. We analyzed the trend in the Normalized Difference...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705488
UC Berkeley Webcast Videos
8,258
8.3K
Feb 17, 2018
02/18
by
Tom Gold; George Breslauer; Barbara Finamore; Orville Schell; Isabel Hilton; Wenran Jiang; C.S. Kiang; Ye Qi; Lili Wang; Roger Cohn; Kirk R. Smith; John Quigley; Piet Eichholtz; Richard Lyons; Julia Levin; Alan Sanstad; Catherine Wolfram; David Pogue; Jennifer Wolch; Phil Williams; Randall Bowie; Peng Gong; Shankar Sastry; Alexandra Sullivan; Doug Gattlin; Martin Townsend; Stephen Selkowitz; Bjorn Harsman; Jiro Yoshida; Raphael Bostic; Severin Borenstein; Stefano DellaVigna; Robert Spear; Aaron...
movies
eye 8,258
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UC Berkeley special events, interviews, and lectures featuring distinguished faculty and guests. To view these events as webcasts visit webcast.berkeley.edu. Full course lectures available, too. Opening and Keynote Opening Remarks Tom Gold , UC Berkeley George Breslauer , Executive Vice Chancellor and Provost, UC Berkeley Keynote Address: China's Environment: Opportunities and Challenges for the International Community Barbara Finamore is a Senior Attorney at the Natural Resources Defense...
Topics: UC Berkeley, Berkeley, Cal, webcast.berkeley, iTunes U, Education, Institute of East Asian Studies,...
UC Berkeley Webcast Videos
2,880
2.9K
Feb 17, 2018
02/18
by
Tom Gold; George Breslauer; Barbara Finamore; Orville Schell; Isabel Hilton; Wenran Jiang; C.S. Kiang; Ye Qi; Lili Wang; Roger Cohn; Kirk R. Smith; Peng Gong; Robert Spear; Feng Ting Li; Lin Jiang; Max Auffhammer; Mark Levine; Larry Li; ZhongXiang Zhang; Jan Hamrin; Jeremy Potash; Robert Collier; Po Chi Wu; Chris Raczkowski; Daniel Spitzer; Gang He; Peter Perdue; Chi-yuen Wang; Michael Zhao; Ma Jun; Julia Strauss; Sheldon Brown; Harrison Fraker; Mark Henderson; Shannon May; Jim Yardley; Julie...
audio
eye 2,880
favorite 6
comment 0
UC Berkeley special events, interviews, and lectures featuring distinguished faculty and guests. To view these events as webcasts visit webcast.berkeley.edu. Full course lectures available, too. Opening and Keynote Opening Remarks Tom Gold , UC Berkeley George Breslauer , Executive Vice Chancellor and Provost, UC Berkeley Keynote Address: China's Environment: Opportunities and Challenges for the International Community Barbara Finamore is a Senior Attorney at the Natural Resources Defense...
Topics: UC Berkeley, Berkeley, Cal, webcast.berkeley, iTunes U, Institute of East Asian Studies,...
California Digital Library
3,644
3.6K
Sep 26, 2006
09/06
by
Triest, Shirley Staschen, 1914-1995. ive; Bancroft Library. Regional Oral History Office; Rainer, Ivan, 1931-; Zabin, Belle, 1922-; Goodfriend, Audrey, 1920-; Triest, Sara Hart, 1950-; Stern, Radha Lisa, 1954; Stern, Gerd; Rainer, Yvonne, 1934-
texts
eye 3,644
favorite 5
comment 0
1 v. (ix, 333 p.) : 28 cm
Topics: Podesta, Alfred, Triest, Frank, d. 1987, Buck, Jane Hamner, Bohemianism -- California San...
129
129
Oct 23, 2014
10/14
by
Wang, Yuan-Hong; Pang, Bei-Bei; Ghosh, Souvik; Zhou, Xuan; Shintani, Tsuzumi; Urushibara, Noriko; Song, Yu-Wei; He, Ming-Yang; Liu, Man-Qing; Tang, Wei-Feng; Peng, Jin-Song; Hu, Quan; Zhou, Dun-Jin; Kobayashi, Nobumichi
texts
eye 129
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This article is from PLoS ONE , volume 9 . Abstract Background: Rotaviruses are a major etiologic agent of gastroenteritis in infants and young children worldwide. Since the latter of the 1990s, G3 human rotaviruses referred to as “new variant G3” have emerged and spread in China, being a dominant genotype until 2010, although their genomic evolution has not yet been well investigated. Methods: The complete genomes of 33 G3P[8] human rotavirus strains detected in Wuhan, China, from 2000...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967987
5
5.0
Jun 29, 2018
06/18
by
Yong-Shun Song; Yao-Gen Shu; Xin Zhou; Zhong-Can Ou-Yang; Ming Li
texts
eye 5
favorite 0
comment 0
The fidelity of DNA replication by DNA polymerase (DNAP) has long been an important issue in biology. While numerous experiments have revealed details of the molecular structure and working mechanism of DNAP which consists of both a polymerase site and an exonuclease (proofreading) site, there were quite few theoretical studies on the fidelity issue. The first model which explicitly considered both sites was proposed in 1970s' and the basic idea was widely accepted by later models. However, all...
Topics: Quantitative Biology, Soft Condensed Matter, Subcellular Processes, Condensed Matter
Source: http://arxiv.org/abs/1603.02453
Due to a technical malfunction that corrupted our recording of our Brink! episode, we're posting an episode we were planning to unleash months from now. Comedian Chad Reid joins us to talk about the Disney Channel Original Movie "The Color of Friendship," a fun family comedy about racial tensions between blacks and whites in the 1970s. As both our guest and our host are white men, you can be sure that this is a sensitive, reverent conversation worthy of this film's NAACP Image Award....
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163
Jul 17, 2014
07/14
by
Zachary De Santos
audio
eye 163
favorite 0
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Summary: A soundscape Series: Sound Scapes Source: http://hackerpublicradio.org/eps.php?id=1352 The Stanford marshmallow experiment (wiki) refers to a series of studies on delayed gratification in the late 1960s and early 1970s led by psychologist Walter Mischel, then a professor at Stanford University. In these studies, a child was offered a choice between one small reward (sometimes a marshmallow, but often a cookie or a pretzel, etc.) provided immediately or two small rewards if he or she...
Topics: Timing, Sensation, 2004
12
12
Jun 27, 2018
06/18
by
Zai Yang; Lihua Xie; Petre Stoica
texts
eye 12
favorite 0
comment 0
The Vandermonde decomposition of Toeplitz matrices, discovered by Carath\'{e}odory and Fej\'{e}r in the 1910s and rediscovered by Pisarenko in the 1970s, forms the basis of modern subspace methods for 1D frequency estimation. Many related numerical tools have also been developed for multidimensional (MD), especially 2D, frequency estimation; however, a fundamental question has remained unresolved as to whether an analog of the Vandermonde decomposition holds for multilevel Toeplitz matrices in...
Topics: Information Theory, Computing Research Repository, Mathematics
Source: http://arxiv.org/abs/1505.02510
9
9.0
May 29, 2018
05/18
by
Zander, Bianca, author
texts
eye 9
favorite 1
comment 0
370, 14 pages ; 21 cm
Topics: Communal living -- New Zealand -- Fiction, Young women -- England -- London -- Fiction, Communal...
14
14
Jun 3, 2020
06/20
by
Zander, Bianca, author
texts
eye 14
favorite 0
comment 0
1 volume ; 20 cm
Topics: Communal living -- New Zealand -- Fiction, Communal living, London (England) -- Fiction, England --...
288
288
Sep 10, 2008
09/08
by
Zannetos, Zenon Soteriou
texts
eye 288
favorite 0
comment 0
Bibliography: leaves [19]-20
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282
Oct 27, 2019
10/19
by
Zannusi
movies
eye 282
favorite 4
comment 1
Jon Pertwee portrays the Third Doctor in this electronics ad from the 1970s.
favoritefavoritefavoritefavoritefavorite ( 1 reviews )
Topics: Doctor Who, doctor who commercial, vintage ad, doctor who ad, British commercial, Jon Pertwee
8
8.0
Mar 23, 2022
03/22
by
Zero, Johnny, 1969-
texts
eye 8
favorite 1
comment 0
375 pages : 21 cm
Topics: Popular music -- 1971-1980 -- Chronology, Popular music, Popmusik -- Grossbritannien -- Geschichte...
1,242
1.2K
May 23, 2018
05/18
by
Zickel, Raymond E., 1934-;Keefe, Eugene K. Area handbook for the Soviet Union;Library of Congress. Federal Research Division
texts
eye 1,242
favorite 44
comment 0
lxxxii, 1068 pages : 24 cm
Topics: Soviet Union, URSS
30
30
Dec 4, 2020
12/20
by
Zielie Band
audio
eye 30
favorite 0
comment 0
This is a self-titled song published in the 1970s.
Topics: cruise, lounge, 1970s, Zieli Band, Rose Garden, self-titled
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27
Nov 11, 2020
11/20
by
Zimmerman, Jean
texts
eye 27
favorite 2
comment 0
xvi, 266 pages ; 24 cm
Topics: Home economics -- United States -- History, Home economics -- United States -- Philosophy, Home...
19
19
Feb 14, 2020
02/20
by
Zimring, Franklin E
texts
eye 19
favorite 2
comment 0
xiv, 210 pages : 24 cm
Topics: Firearms -- Law and legislation -- United States, Gun control -- United States, Firearms -- Law and...
126
126
Nov 13, 2018
11/18
by
Zinman, David (David H.)
texts
eye 126
favorite 8
comment 0
ix, 246 pages : 28 cm
Topics: Motion picture plays -- History and criticism, Motion picture plays, Film, USA
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54
May 4, 2021
05/21
by
Zinoman, Jason
texts
eye 54
favorite 8
comment 0
1 volume
Topics: Horror films -- United States -- History and criticism, Horror films, United States
51
51
Mar 25, 2021
03/21
by
Zinoman, Jason
texts
eye 51
favorite 12
comment 0
274 p., [8] p. of plates : 25 cm
Topic: Horror films -- United States -- History and criticism
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41
Aug 9, 2020
08/20
by
Zinsser, Judith P
texts
eye 41
favorite 6
comment 0
x, 204 pages ; 25 cm
Topics: Women's studies -- United States, Women -- United States -- Historiography, Education, Higher --...
4
4.0
Jun 30, 2018
06/18
by
Ziyu Gu; Wim Ubachs
texts
eye 4
favorite 0
comment 0
Spontaneous Rayleigh-Brillouin scattering experiments in air, N2 and O2 have been performed for a wide range of temperatures and pressures at a wavelength of 403 nm and at a 90 degrees scattering angle. Measurements of the Rayleigh-Brillouin spectral scattering profile were conducted at high signal-to-noise ratio for all three species, yielding high-quality spectra unambiguously showing the small differences between scattering in air, and its constituents N2 and O2. Comparison of the...
Topics: Physics, Optics
Source: http://arxiv.org/abs/1409.3014
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80
Sep 22, 2013
09/13
by
Zizhou Tang; Weiping Zhang
texts
eye 80
favorite 0
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We show that every Eells-Kuiper quaternionic projective plane carries a Riemannian metric such that all geodesics passing through a certain point are simply closed and of the same length. This result resolves a longstanding problem of Berard-Bergery and Besse dating back to 1970s.
Source: http://arxiv.org/abs/1302.2792v1
1
1.0
audio
eye 1
favorite 0
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So we kick off the Movie Club project with a real winner, if by winner we mean the best case of European child abuse in the 1970s. Fernando Arrabal's Long Live Death is confounding, surreal, thought-provoking, but also quite bad. Even so, it yields stimulating conversation despite mild disagreement on what the film is actually saying. We tangent slightly toward the strength of symbolism generally in films as well as a sober wrap-up talk of our own recent filming project. Download here! If...
1
1.0
Apr 23, 2022
04/22
by
Zoe Marie Griffith; Martin S. Hagger
data
eye 1
favorite 0
comment 0
Political orientation, a socio structural variable commonly operationalized as a person’s self-identified position on scales ranging from political left (“liberal”) to right (“conservative”) (Carney et al., 2008); Kivikangas et al., 2021; Osborne et al., in press; Van Hiel et al., 2021), has been linked to various health outcomes (Kannan & Veazie, 2018; Subramanian & Perkins, 2010). For example, differences in morbidity and mortality have been observed between individuals that...
Source: https://osf.io/2puzv/
2
2.0
Jul 26, 2022
07/22
by
Zoglin, Richard
texts
eye 2
favorite 0
comment 0
247 p. : 25 cm
Topic: Stand-up comedy -- United States -- History -- 20th century
14,153
14K
Dec 5, 2016
12/16
by
Zondervan
texts
eye 14,153
favorite 11
comment 0
The impact of The Late Great Planet Earth cannot be overstated. The New York Times called it the “no. 1 non-fiction bestseller of the decade.” For Christians and non-Christians of the 1970s, Hal Lindsey’s blockbuster served as a wake-up call on events soon to come and events already unfolding—all leading up to the greatest event of all: the return of Jesus Christ. The years since have confirmed Lindsey’s insights into what biblical prophecy says about the times we live in. Whether...
Topics: Hal Lindsey, Christian Eschatology, doomsday, Great Tribulation, Mark of the Beast. Gog and Magog,...
1
1.0
Dec 27, 2019
12/19
by
ZoneOneRadio - #LondonGP
audio
eye 1
favorite 0
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Matthew presents #LondonGP - your weekly motor sport and music extrravaganza on ZoneOneRadio This week the second installment of co-presenter Rupert Suren’s adventures at the Goodwood Festival of Speed He’ll be talking to 1970s Ferrari driving legend Arturo Mezario. If you haven’t seen the spectacular before and after photos of him it’s really worth a look - facebook.com/matthewontheradio Rupert will also be talking affordable motor sport with Steve Pickup of Chevron Cars And of course,...
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167
May 26, 2018
05/18
by
Zukowsky, John, 1948-;Art Institute of Chicago;Museum of Flight (Seattle, Wash.)
texts
eye 167
favorite 11
comment 0
191 pages : 31 cm
Topics: Launch complexes (Astronautics) -- Design and construction -- Exhibitions, Architecture, Postmodern...
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84
Oct 10, 2014
10/14
by
de Faveri Favero, Fabricio; Grando, Rogerio; Nonato, Fabiana R; Sousa, Ilza MO; Queiroz, Nubia CA; Longato, Giovanna B; Zafred, Rafael RT; Carvalho, Joao E; Spindola, Humberto M; Foglio, Mary A
texts
eye 84
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This article is from BMC Complementary and Alternative Medicine , volume 14 . Abstract Background: Artemisia annua L. has been used for many centuries in Chinese traditional medicine. Artemisinin, the active principle was first isolated and identified in the 1970s becoming the global back bone to the fight against malaria. Our research group previously developed an economic and ecological friendly process to obtain this compound. In the pursuit to also exploit the residue generated throughout...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122781
