Diabetologia 1981: Vol 20 Index & Table of Contents

Author Index

Page numbers referring to Abstracts are italicized

Ahrén, B. 54
Alam, M.J. 667
Alberti, K.G.M.M. 113,
123, 664, 667, 670, 677
Albisser, A.M. 51
Alexander, W.D. 664
Andersen, A.R. 457
Anderson, D. 664
Andersson, A. 60, 237
Andrews, W.J. 664
Angervall, L. 558
Ashcroft, S.J.H. 642, 672

Bailey, C.J. 573

Bakir, S.M. 592

Ball, M.R. 664

Barbosa, J. 506

Barker, A.P. 667

Barnett, A.H. 87, 664, 673

Baron, M. 674

Barrie, T. 665

Bath, P.M.W. 665

Baumann, F.G. 31

Baylis, P.H. 607

Beastall, G.H. 667

Beck-Nielsen, H. 636

Beckett, A.G. 665

Benn, J. 190

Benraad, T.J. 553

Bereiter, D. A. 417

Berelowitz, M. 66

Berger, M. 547

Bernardis, L.L. 357

Bersani, G. 47

Berthoud, H.-R. 245, 393,
417

Besterman, H.S. 665

Betterle, C. 47

Betts, S.A. 535

Binder, C. 530

Bittlestone, R.G.A. 665

Blackburn, A.M. 665

Blackburn, G.L. 616

Blair, A.L.T. 665

Blair, T. 67/

Blayac, J.P. 501

Bloom, S.R. 665, 677

Blotman, M.J. 12

Bodansky, H.J. 585, 666,
668, 677

Bone, A.J. 666

Bonnevie-Nielsen, V. 457

Boroujerdi, M.A. 676

Borst, C. 244

Bottazzo,G.F. 106, 672, 675

Bottermann, P. 159

Boulton, A.J.M. 666

Bourgoignie, J.J. 223

Bowcock, S.A. 672

Brandenburg, D. 667

Bratusch-Marrain, P. 586

Bray, G.A. 366

Brederode, J.F.M. van 244

Brodows, R.G. 482

Brooks, A.P. 666

Brown, M. 299

Brown, P.M. 674, 676

Brownstein, M. 268

Buchanan, K.D. 664, 667,
671

Burke, B.J. 511, 666

Burrin, J.M. 667

Cagliero, E. 667
Calne, R. Y. 670
Campbell, R.G. 482
Cannon, D.J. 242
Carson, E.R. 676
Carter, T.J.N. 535
Castex, Ch. 489
Chait, A. 625
Chakrabarti, R. 674
Cheto, D. 510
Chignell, A.H. 674
Christie, M.R. 672
Chuter, P.J. 676
Clarke, B.F. 602
Clarke, J. A. 673
Clement-Jones, V. 672
Cohen, H.N. 667
Cole, E.M.A. 667
Cole, M. 669
Colette, C. 12
Conaway, H.H. 242
Cooke, E.D. 672
Cordera, L. 677
Cousins, S. 667
Cudworth, A.G. 83, 106,
666, 668, 672, 675, 677
Curchod, B. 39

Dandona, P. 665
Davidson, R.J.L. 583
Davis, R.E. 672
Davis, T.M.E. 667
Day, J.L. 666
Deckert, T. 60

De Hertogh, R. 578
De Leeuw, I. 145
De Vos, J.C. 563
D’Hollander, M. 145
Dickenson, C.J. 673
Dijs, B. van der 78
Ditschuneit, H. 155
Dodson, G. 667
Dodson, P.M. 668
Donnelly, T. 667
Dornan, T.L. 668
Drury, P. 666
Drury, P.L. 668
Duff, D. A. 668
Duncan, L.J.P. 677
DuToit, D. 672
Dyrberg, T. 190

Eckel, R.H. 186
Eden, B.W. 676
Edmonds, M.E. 668

Edwards, A.V. 665
Edwards, C.R.W. 668
Edwards, E.E. 676
Edwards, O.M. 676
Efendi¢, S. 495

Eff, C. 60, 87

Ekka, E. 578

Eldred, N. 664
Elkeles, R.S. 669
Eriksson, U. 237
Evan-Wong, L.A. 583

Faber, O.K. 530
Farrer, M. 667
Felber, J.-P. 39
Feldman, J.M. 148
Fernstrom, J.D. 281
Ferriss, J.B. 669
Fielding, A.S. 665
Fineberg, S.E. 616
Fischer, U. 51
Flanagan, R. 667
Flatt, P.R. 573, 669
Fleming, N. 670
Fogelman, I. 667
Foulds, W.S. 665
Frandsen, M. 199, 451
Fraser, K.J. 674
Frayn, K.N. 139
Freedman, D.B. 665
Freedman, Z. 471
Frier, B.M. 677
Friisberg, B. 457
Frohman, L.A. 66
Fujimoto, W. Y. 186
Fujimoto, K. 568
Furman, B.L. 669
Fyffe, J. A. 667

Galton, D.J. 668
Gammelgaard, J. 451
Gardner, M. 667
Gasparo, M. de 672
Gerich, J.E. 669
Gibby, O.M. 670
Girardier, L. 362
Gliemann, J. 630, 636
Goldman, J.K. 357
Gonggrijp, H. 669
Gordon, D.A. 79

Gorsuch, A.N. 106, 677

Gonzales, A.-M. 675

Gonzelez-Auvert, C. 673

Goto, Y. 66

Gower, R. 664
Gray, R.S. 602, 670
Green, A. 468
Green, F. 665
Griffin, J. 670

Grill, V. 495
Grobin, W. 18
Groot, G. de 45
Gross, R. 72

Grover-Johnson, N.M. 31
Gylfe, E. 669

Hadden, D.R. 665, 67]
Hagglof, B. 471
Hales, C.N. 671, 675
Hammond, V.A. 677
Hanning, I. 670
Hart, A.J. 665
Hartog, M. 80
Hauge, M. 468
Havranek, T. 129
Havrankova, J. 268
Heasman, M.A. 673
Heding, L.G. 669
Heijst, A.N.P. van 45
Hellerstrom, C. 666
Hellman, B. 669
Hendriks, T. 553
Henquin, J.-C. 540
Henry, R.W. 664
Henze, K. 625
Herd, R. 602
Herfort, K. 129
Hermann, G. 331
Hill, R.D. 670
Hillson, R.M. 670
Hilsted, J. 190
Hjollund, E. 636
Hockaday, T.D.R. 507, 668,
670
Hodson, A. 113
Holdsworth, G. 668
Holm, N.V. 468
Holman, R.R. 667, 670
Holmgren, G. 471
Home, P.D. 670
Hothersall, J.S. 671]
Houten, M. van 255
Howie, E.Y. 675
Hreidarsson, A.B. 475
Hutton, J.C. 67/, 675
Hwang, K.H. 223

Imperato, A.M. 31

Inoue, S. 366
Ionescu-Tirgoviste, C. 510
Ireland, J. 672

Irvine, J. 471

Iselin, H.U. 39

Itoh, M. 669

Jakobsen, J. 110
Jarrett, R.J. 507, 592
Jatoi, I. 213
Jeanrenaud, B. 217, 245,
393, 417
Jenkins, A. 667
Jenson, A.B. 462
Jéquier, E. 39
Johnston, D.G. 123
Johnstone, F. 675
Jones, M.S. 102
Jones, R.H. 665

680

Karlsson, K. 558
Kay, R.M. 18
Keck, E. 547
Kelly, U. 673
Kennedy, A.L. 665
Kennedy, L. 671
Kennedy, N.J. 305
Kim, G.E. 31
Kim, Y. 213

Kim, Y.S. 213
Kita, H. 290

Klatt, C. 148
Kodis, M. 357
Kohner, E.M. 667
Koivisto, V. 84
Kolterman, O.G. 670
Krarup, T. 530

Lakili, M. 72
Lang, D.A. 672
Laughton, W. 378
Laurent, F. 72
Lechin, F. 78
Lernmark, A. 471
Leslie, R.D.G. 87
Lewis, S.B. 674
Lilavivat, U. 482
Lindgarde, F. 134
Lindskov, H.O. 636
Lisch, H.-J.; 118
Lister, J. 677
Loke, M. 670
Lotter, E.C. 305
Loubatiéres-Mariani,
M.M. 501
Lougheed, W.D. 51
Lowe, J. 517
Lowy, C. 22
Luboshitzky, R. 357
Ludvigsson, J. 471
Lundquist, I. 54
Luzio, S.D. 67]

MacCuish, A.C. 665, 667
MacFadyen, R.J. 67]
MacKenzie, G.H. 79
MacKenzie, R.G. 357
Mackman, J.M. 670
Madsbad, S. 530
Madson, K.L. 314
Maeder, E. 39

Maes, R.A. A. 45
Manderson, W.G. 667
Mann, J.I. 507, 673, 674
Markwick, J.R. 677
Martin, T.R.P. 666
Martinsson, A. 558
Massi-Benedetti, M. 670
Matthews, D.R. 672
Matthews, K.A. 535
McCall, M. 667
McCann, V.J. 672
McCarthy, M.U. 676
McEwan, C. 674
McKay, L.D. 305
McLaren, E.H. 675
McLean, P. 664, 67]
McMaster, P. 670
Meade, T.W. 674

Medbak, S. 672
Metcalfe, J. 666
Metcalfe, P. 123
Meyer, H.U. 39
Mialhe, P. 72
Micossi, P. 510
Millard, M.M. 223
Miller, R.E. 102
Milles, J.J. 607
Milner, R. D. G.
Mitchell, T. 664
Mirouze, J. 12
Moloney, A. 672
Monnier, L.H. 12
Monnier, M.P. 12
Morgan, L. 612
Morrison, N.D. 668
Mutch, W.J. 672

672, 674

Nerup, J. 190

Nicol, D.J. 672
Nicolaidis, S. 426
Nielsen, J.H. 60
Niijima, A. 325
Nishizawa, Y. 366
Nosadini, R. 113, 123
Novin, D. 331

Noy, G.A. 113

Oakley, N. 673
O’Connor, N. 612
Oddie, C.J. 668
Olefsky, J.M. 670
Onodera, T. 462
Oomura, Y. 290
@rskov, H. 113, 123
O’Sullivan, D.J. 669
Owens, C. 80, 666, 676
Owens, C.J. 511

Padovan, D. 47
Pahud, P. 39

Paisey, R. 80

Paisey, R.B. 669, 676
Panzram, G. 587
Pardridge, W.M. 246
Parsons, J.A. 675
Parving, H.-H. 199, 451, 457
Patterson, C.C. 673
Pav, J. 129

Peacock, I. 673
Pearson, M.W. 673
Pearson, T. 674
Peckar,C.O. 668
Pedersen, O. 630, 636
Penn, E.J. 671, 675
Pennell, J.P. 223
Pennock, C. 80, 676
Pennock, C.A. 511, 666
Perkins, J.R. 22
Perlman, K. 51
Peshavaria, M. 67]
Petersson, B. 237
Pfeifle, B. 155
Pierluissi, J. 642
Pierluissi, R. 642
Pilling, J. 666

Pim, B. 670
Pipeleers, D.G. 654

Pipeleers-Marichal,
M.A. 654
Popa, E. 510
Porta, M. 667
Porte, D., Jr. 245, 274, 305
Porte, S.G. 305
Posner, B.I. 255
Powley, T.L. 378
Pozzilli, P. 106
Price Evans, D. A. 666
Puech, R. 501
Pyke, D.A. 87, 664, 673

Rafferty, A.B. 665
Rahier, J. 540
Ramsay, R. 506
Rasch, L.L. 468
Reaven, G.M. 508
Rees, L.H. 672
Reeves, W.G. 673
Regeur, L. 530
Reibring, L. 237
Reid, R. 676
Reinila, A. 205
Reith, S. 674
Ribes, G. 501
Rogers, R.C. 331
Rohner-Jeanrenaud, F. 217,
417
Rostron, W. 673
Roth, J. 268
Rousselle, J. 39
Roy, M.W. 102
Ruben, A. 674
Rundfeld, M. 495

Sailer, S. 118
Sakaguchi, T. 568
Saltin, B. 134
Samols, E. 388
Sandahl Christiansen, J. 190,
199, 451
Sangster, B. 45
Sarson, D.L. 677
Sasaki, A. 195
Saunders, J.B. 673
Scarlett, J. A. 670
Scarpello, J.H.B. 666
Schmitt, J.K. 674
Schneider, S.H. 616
Sclafani, A. 402
Scobie, I.N. 665
Seigler, H.F. 148
Selvaggio, S. 462
Sensi, M. 106
Seydoux, J. 362
Sheffrin, R. 674
Shenouda, F. 674
Shepherd, G.A.A. 670
Shepperd, J. 664
Sherwin, R.S. 84
Shilling, J. 674
Shimazu, T. 343
Sidenius, P. 110
Siegel, E.G. 393
Simpson, H.C.R. 507, 674
Skrha, F. 129
Skrha, J. 129
Smidt, U.M. 457

Author Index

Smith, A. 675

Smith, B. 670

Smith, L. 667

Smith, P.G. 673

Smith, P.H. 314

Snell, K. 668

Sochor, M. 675

Sodoyez-Goffaux, F. 563

Sonksen, P.H. 22, 665, 674,
676

Sommerville, J.M. 675

Sonne, O. 636

Sopwith, A.M. 675

Soyodez, J.C. 563

Spencer, K.M. 677

Spiliopoulos, A.J. 664

Sramkova, J. 129

Stagner, J.I1. 388

Starke, A. 547

Steel, J.M. 675, 677

Steemson, J.M. 668

Steffens, A.B. 411

Stein, L.J. 305

Stépan, J. 129

Stevenson, R.W. 675

Stirling, Y. 674

Stocks, J. 668

Stowers, J.M. 583, 672, 673

Strubbe, J.H. 228

Stubbs, W.A 664

Suarez, 5.~. 524

Sullivan, P.A. 669

Sutherland, D.E.R. 161,
435

Sutter, B.Ch.J. 489

Swenne, I. 237, 666

Tattersall, R.B. 517, 673
Taylor, K.G. 535
Thomas, D. 675
Thomas, P.K. 31
Thompson, P. 675
Thorogood, M. 673
Tindall, H. 676
Toledo-Pereyra, L.H. 79
Tooke, J.E. 676

Track, N.S. 18

Tredger, J. 612

Trimble, E.R. 393, 501
Tunbridge, M. 672
Turner, G. 666

Turner, R.C. 667
Turner, R.C. 672

Ui, M. 568

Umpleby, A.M. 676
Unger, R.H. 1
Uvnas-Wallenstein, K. 337

Valente, A.J. 535
Vanderheyden, I. 578
Van Eerdewegh, P. 524
Van Rooy, P. 145
Verdonck, L.F. 45
Vervaert,C. 148
Vierhapper, H. 586

Wachem, P. van 228
Waldhausl, W. 586

Subject Index

Wallon, J. 540

Walshe, K. 67]

Ward, J.D. 666

Wass, J.A.H. 672
Watkins, P.J. 668, 672
Weaver, J.A. 665, 671
Weir, G.C. 388

Wells, L. 677

West, D.B. 305

Subject Index

A cell, 72, 388, 540, 654

Acetaldehyde, 673

Acetoacetate, see Ketone

Acetylcholine, 281, 388

Acid cholesterol ester hydrolase, 625

Acyl-amino-alcyl benzoic acid derivative,
501

Adenine nucleotide translocase, 664

Adolescence, 517

Adrenal epinephrine secretion, 299

Adrenergic blockade, 482

Alanine, 113

Alcohol, 672

Aldosterone, 669

Alloxan, 66, 664, 675

Amino acids, 563, 672

Aminoisobutyric acid, 213

Amylase isoenzymes, 129

Angiotensin II, 669

Antibody

— dependent cell-mediated cytotoxicity,
106

— to human insulin, 673

— islet cell, 471, see also Pancreatic islet
cell

Apolipoprotein

— A-I, 535

— A-IIl, 668

APUD cells, 314

Arginine, 495, 541

Artificial endocrine pancreas, 113

Atherosclerosis, 155

Atropine, 217, 366, 402

Autoimmunity, 471, 675

Autonomic nervous system
and gastroenteropancreatic system, 314
and glucagon and insulin secretion, 411
and hypothalamic integration, 378
reversible abnormalities, 475
and somatostatin, 388

Autonomic neuropathy, 244

Autoradiography, 237, 255

Axonal transport, 110

Baboons, 274

Basement membrane

— muscle capillary, 664
— thickening, 205

BAY g 5421, 586

B cell

— autonomic control, 388
— denervation, 393

— function, 511

West, T.E.T. 22, 676
Wheatley, T. 676
Wheeler, J.
Whiffen, G.P. 665
Whitcher, J.
White, D. 80, 676
Whittaker, J.
Wieling, W.
Williams, R.

244

Wills, P.D. 664

462 Wise, P. 664

Wolf, E. 585, 677

676 Wollheim, C.B. 501

Wollmer, A. 667
677 Wood, S.M. 677

human, cultured and reovirus type 3,
462
in human neonates and infants, 540
innervation, 228
plasma membrane, 669
purification, 654
residual function in IDD, 530
secretion in edible dormouse, 489
in transplanted islets, 237
Beat-to-beat variation, 190
Beta-endorphin, 1, 305, 672
Beta-hydroxybutyrate, see Ketone
Beta-microglobulin, 199
Biothesiometer, 670
Blood-brain barrier, 246
Blood-retinal barrier, 597
Bombesin, 299, 305
Bone mass, 145
Brain
— metabolism, 246
— neurotransmitter synthesis, 281
Brown fat, 343, 362
Buformin and lactic acidosis, 45

Calcitonin, 547
Calcium, 343, 547
45-Calcium, 669
Calf, 665
Catecholamines, 281, 482
Cation binding sites, 669
Central nervous system
— action of neuropeptides, 299
control of metabolism, 299, 343
and glucoregulation, 1
and insulin
— — action, 255
— — feedback, 274
modulation of pancreatic exocrine func-
tion, 417
Cephalic-phase insulin response, 393
Chlorpropamide, 22, 669, 672
Chlorpropamide-alcohol flush, 510, 673
Cholecystokinin, 305, 325
Cholesterol, 22
Choline, 281
Circumventricular organs, 255
Claudication, 666
Clearance, 223
Clofibrate, 673
CNS, see Central nervous system
Collagenase, 630
Column chromatography, 676
Complement, 677

Williamson, J.R. 664

Woods, S.C. 245, 274, 305
673 Wright, A.D. 535, 607

Yanagawa, N. 223
Yoon, J.W. 462
Yoon, Y. 213
Young, A. 675
Young, R.J. 677

Zabel-Langhenning, R. 587
Zanco, P. 47
Zimmermann, H. 547

Control of meal size, 305
Corticosterone, 563

Cortisol, 1, 482

Coupling of islet cells, 654
C-peptide, 511, 530, 547, 669
Creatinine, 457
Cyclooxygenase inhibitors, 676

DAMME, 642
D cell, 388, 495, 654
Degenerative joint disease, 675
2-deoxyglucose, 72, 325, 331, 366, 630
Diabetes mellitus
— in adolescence, 517
aetiology, 87, 106
and amylase isoenzymes, 129
arterial wall changes, 205
and autoimmune thyroid disease, 602
and autoimmunity, 47
and basement membrane thickness, 664
and brain function, 281
calcium and calcitonin, 547
and cyclooxygenase inhibitors, 676
and delayed menarche, 510
diagnosis, 195
dietary treatment, 507, 508, 665, 674
epidemiology, 673
and exercise, 84
experimental, 675
genetics, 87,524, 677
and genetically susceptible unaffected
siblings, 106
and glomerular filtration rate, 451
injury, and muscle protein, 139
insulin action, 670
(insulin action) in fibroblasts, 186
— infusion and renal function, 199
and islet cell antibodies, 471
and kidney size, 451
and leucine turnover, 676
and lipoproteins, 118, 535
and lysosomal enzymes, 625
medial arterial calcification, 668
mortality, 672
— and neuropathy, 475
and obesity, 39
— pathophysiology, 1
prevalence, 468
prognosis, 195, 587
and red cell volume, 583
and renal plasma flow, 451
and renin, 668

682

and reversible nervous abnormalities,
475
and rheumatoid arthritis, 675
skeletal metabolism, 667
and vasopressin, 607
vertical transmission, 674
and vibration sense, 670
virus-induced, 462
Diabetic
— autonomic neuropathy, 31, 190, 244
— complications and pancreatic/islet
transplantation, 161
control
— in adolescence, 517
— and fibre, 12
nephropathy, 190, 457, 672
neuropathy
aetiology, 110
and claudication, 666
morphometry in, 31
pupillography, 475
patient data storage and analysis, 665
— education, 674
pregnancy, 665, 671
retinopathy
— and autonomic neuropathy, 190
— dilating drops, 663
and endothelial cell function, 597
— HLA association, 506, 585
— and platelet volume, 667
— screening, 665, 670
serum, 60
treatment, 602, 669
urinary ethanol, 664
vascular disease, 31
Diagnostic criteria for diabetes mellitus,
195
Diencephalon, 393
Diet, 118, 507
— and diabetes mellitus, 665
Dog, 675
Dopamine, 148, 388
Dorsal motor nucleus, 331
Double-labelled immunofluorescent anti-
body staining, 462

Edible dormouse (Glis glis), 489

Electroendosmosis, 676

Electrogenic protein translocating system,
671

Enkephalin, 642

Enteric nervous system, 314

Enteroinsular axis, 1

Epinephrine, 366, 568

Epineurial arterioles in sural nerve, 31

Ethanol, 664

Exercise and diabetes, 84

Factor-VIII complex, 597
Fast acetylators, 666

Fasting glucose, 675

— — and vibration sense, 670
Fetal

— macrosomia, 213

— rat liver, 647

— rate of substrate influx, 213
Feto-placental unit, 563
Fibre

— and insulin-dependent diabetes, 12

— and non-insulin dependent diabetes, 18

Food intake

— hypothalamic control, 378, 426

— — obesity, 366

— regulation by insulin, 274

Forearm perfusion, 616

Fractional clearance of neutral dextrans,
223

Gas chromatography, 45
Gastric inhibitory polypeptide, 18, 667
Gastrin, 54, 337
Gastrin-releasing peptide, 299
Gastro-entero-pancreatic hormones, 664
Gastro-entero-pancreatic system, 314
Genetically-obese rodents, 362
Glibenclamide, 22, 673, see also Sulpho-
nylurea
Glomerular
— filtration rate, 199,223, 451, 457
— permeability, 223
Glucagon
and calcium and calcitonin, 547
in calf, 665
and glucoregulation, 1
and glucose clamping, 113
and growth hormone, 123
in human neonatal pancreas, 540
and hypoglycaemia, 482
and hypothalamic obesity, 366
and hypothalamus, 343
immuncreactive, 553
metabolic effects during forearm perfu-
sion, 616
release, see also Glucagon secretion
— effect of insulin, 72
— from isolated rat pancreatico-duode-
nal preparation, 66
secretion, see also Glucagon release
— autonomic control, 388
— CNS modulation, 417
glucose-priming, 499
and hypoglycaemic agents, 501
— hypothalamic control, 426
— and hypothalamus, 411
— isolated perfused rat pancreas, 217
— inrat fetus, 563
— and serotonin, 669
Gluconeogenesis, 94, 357
Glucoreceptor neuron in hypothalamus,
290
Glucoregulation, 1
D-Glucose
— and blood-brain barrier, 246
— clamp, 113, 670
— control, 530, 674
— dependent insulinotrophic polypep-
tide, 677
effect on vagal afferents, 325
fetal rat, 563
and forearm perfusion, 616
and glucagon release, 72
and growth hormone excess, 123
homeostasis, 228
and hypoglycaemic agents, 501
and islet insulin, 666
and insulin release, 54
during low-dose insulin infusion, 592
metabolism, 72

Subject Index

oxidation, 39
priming, 495
regulation, 411
stimulated insulin secretion
storage
tolerance
— and cephalic phase insulin response,
393
and guar, 612
impaired, 195
and islet cell antibodies, 672
in ob/+ mice, 573
obesity and physical activity, 134
— test, 39, 195
transport, 630
turnover, 94
uptake, 186
— urine v. blood tests, 676
Glycerol, 616
Glycogen, 647
Glycogen synthetase, 343
Glycogenesis, 343
Glycogenolysis, 343
Glycosylated haemoglobin
— and aldimine intermediate, 672
— colorimetric assay, 671
— incord blood, 666
in diabetic rabbit, 242
and fibre, 12
and iron deficiency, 666
and large babies, 675
methodology, 676
and oral contraceptives, 673
rapid changes, 80, 159, 676
and red cell
— age, 664
— volume, 583
— — and tissue hypoxia, 674
Goldthioglucose, 145
Grave’s disease, 602
Greyhound, 94
Growth hormone
— — excess, 123
— and glucocounterregulation, 482
— and sulphonylurea therapy, 22
GTG-mice, 145
Guar gum, 612
Gustatory-visceral interaction, 331

Haemoglobin A,, see Glycosylated
haemoglobin

Haloperidol, 78

HB699, 501

Hb A,, see Glycosylated haemoglobin

Hb A,,, see Glycosylated haemoglobin

HDL, 118

HDL-cholesterol, 535, 671

Hepatocytes, 647

HLA complex, 87, 506, 524, 585, 677

Hormone feedback, 255

Human

— adipocytes, 630, 636

— fibroblasts, 186

— islet tissue, 435

— neonatal pancreas, 540

— pancreatic B cell cultures, 462

Hunger, 331

5-hydroxytryptamine, see Serotonin

Hyperglycaemia, 113, 237, 568

Subject Index

Hyperinsulinaemia, 402, 568
Hyperphagia, 402
Hypertension, 457
Hypertriglyceridaemia, 535, 667
Hypoglycaemia, 148, 482, 675
Hypothalamic obesity, 343, 366, 402
Hypothalamus
— and cephalic phase insulin response,

393

and control of feeding, 426

insulin action upon, 255

insulin receptors, 268

integration of autonomic responses,

378

lateral, 290, 343, 411, 426

— stimulation, 417

regulation of metabolism, 343

taste units, 426

ventromedial, 290, 343, 411

— lesions, 357, 366, 402, 417
Hypothyroidism, 602

IDD, see Diabetes mellitus
Identical twins, 87, 664
Immunocytochemistry, 237, 540
Indirect calorimetry, 39
Infants of diabetic mothers, 511
Injections, 517
Insulin
— action
— onAcells, 72
— in brain, cellular basis, 255
— in diabetic fibroblast cultures, 186
— in rodent brain, 268
— onsmooth muscle cells, 155
binding sites in brain, 290
biosynthesis, 666
bovine, 673
brain, 268
— content, 290
in calf, 665
cerebrospinal fluid, 274
chemically-modified (A, B39), 94
crystalline, 51
deactivation in vivo, 670
delivery
— and growth hormone excess, 123
— and leucine, 676
degradation, 636
dependent diabetes mellitus, see Diabe-
tes mellitus
dissolution time, 51
in fetal rat pancreas culture, 672
and food intake, 274
and forearm perfusion, 616
and glucoregulation, 1
and glucose transport, 630
human, 673
— in neonatal pancreas, 540
— semi-synthetic, 670
and hypothalamic obesity, 366
and hypothalamus, 343
infusion
— intravenous, 199, 667
— intraventricular, 274
— low-dose, 592
— subcutaneous in dog, 675
injection sites, 677

internalisation by hepatocytes, 677
intrauterine injection in pregnant rat,
607
and lipodystrophy, 677
and lysosomal enzyme activity, 625
oedema, 676
porcine, 670
prescriptions, 468
receptor
— binding, 636, 647
— hypothalamic, 255
— in rodent brain, 268
release, see Insulin secretion
response to GIP, 677
secretion
— and adrenergic stimulation, 54
— arginine induced in VMH-lesioned
rat isolated pancreas, 217
autonomic control, 388
and B cells infected with reovirus
type 3, 462
and calcium and calcitonin, 547
and chlorpropamide, 669
and cholinergic stimulation, 54
CNS modulation, 417
endogenous, 530
and enkephalins, 642
and gastrin, 54
glucose-priming, 495
and haloperidol, 78
and hypoglycaemic agents, 501
hypothalamic control, 426
and hypothalamus, 411
from islet cell tumour, 675
from isolated mouse islets, 60
and isolated rat pancreatico-duode-
nal preparation, 66
from nerves, 337
neural control, 290
and neurotensin, 665
in ob/+ mice, 573
pancreatic pacemaker, 672
perfused dog pancreas, 102
in rat fetus, 563
seasonal changes in edible dormouse,
489
and secretin, 54
and serotonin, 669
in transplanted neonatal pancreas,
228
— and VIP, 54
secretory granule, 67/
semi-synthetic human mutant, 667
sensitivity and physical activity, 134
solubility, 51
structure-function relationships, 94
treatment and lipoproteins, 118
and vagal pancreatic afferents, 325
vasopressin, 607
withdrawal, 607
Insulinoma, 148
Intrauterine insulin injections, 558
Islets of Langerhans, see Pancreatic islets
Isolated hepatocytes, 677
Isolated pancreatic islets, see Pancreatic
islets
Isolated rat pancreatico-duodenal prepa-
ration, 66
Isoproterenol, 568

683

Juvenile diabetes, see Diabetes mellitus

K*, see Potassium

Ketogenesis, 667

Ketone bodies

— and blood-brain barrier, 246

— during forearm glucagon perfusion, 616
— and growth hormone excess, 123

— and hyperglycaemia clamping, 113
Kidney size, 451

“Killer” ceils, 196

KK mice, 568

Lactate, 113, 482, 616

— /pyruvate ratio, 22

Lactic acidosis and buformin, 45
Lanthanum-wash technique, 669
Lateral hypothalamic nucleus, 343
— hypothalamus, 290, 343, 411, 426
LDL, 118, 625

— /HDL ratio, 674

Leucine, 186, 213, 676

Lipids, 67/

Lipodystrophy, 677

Lipogenesis, 343, 357

Lipolysis, 343

Lipoprotein, 118, 668
Lymphocytes, T and B, 47
Lysosomal enzymes, 625

Mannose, 325

Medial arterial calcification, 668
Menarche, 510

Metabolic efficiency, 362
Met-enkephalin, 672
Metformin, 673

Methacholine, 217
Methylglucose, 630
Microcomputer, 665
Monoamine oxidase, 148
Mononuclear cells, 625

Mouse

— KK, 568

— ob/ob, 237, 417, 573

— ob/+, 573

Muscle

— capillary basement membranes, 664
— protein, 139

— smooth, 155

Myoinositol, 67/

N-acetyl-B-glucosaminidase, 625

Naloxone, 305, 642

Necrobiosis lipoidica diabeticorum, 87

Neonates, 540

Nephrectomy, 675

Nephropathy, 190

Nerve crush, 110

Neurocrine signalling, 314

Neuropathy, 31, 190, see also Autonomic
neuropathy

Neurotensin, 665

NMRI mice, 60

Non-esterified fatty acids, 482, 592, 616

— insulin dependent diabetes, see Diabe-
tes Mellitus

Norepiniphrine, 148

Nucleus ambiguus, 417

— tractus solitarius, 331, 393

684

Obesity
— and cephalic phase reflex insulin secre-
tion, 393
and diabetes mellitus, 39
and gastro-entero-pancreatic hor-
mones, 664
and glucose tolerance, 134
hypothalamic, 366
and insulin sensitivity, 592
and neonatal rat, 668
regulation, 274
and vagally mediated insulin release, 402
and ventromedial hypothalamic lesions,
357
Ob/ob mouse, 237, 417, 573
Oedema, 676
Oestrogen induced protein synthesis, 578
Ornithine, 675
Oro-glycaemic reflex, 426

Pancreas
— autonomic control, 388
— fetal rat, 672
— isolated perfused rat, 217
—, perfused
—,— edible dormouse, 489
—,— rat, 495
— rat neonatal, 228
— transplant registry, 435
— transplantation, 228, 435
Pancreatectomy, subtotal in ducks, 72
Pancreatic
— function, 129
glucagon, 553
islet, 642
cell
— antibodies, 47, 87, 106, 471, 672
preparation for transplant, 79
— replication, 237
— surface antibodies, 471
— tumour, 675
culture, 642
and glucoregulation, 1
human, 435
isolated, 60
— rat, 654
— — neonatal, 563
paracrine signals, 1
in tissue culture, 60, 666
transplant registry, 435
transplantation, 161
— clinical trials, 435
— intrasplenic in ob/ob mice, 237
pacemaker, 672
polypeptide, 501, 540, 665
splanchnic nerve, 290
transplantation, 161
— metabolic profiles, 670
vagal nerve, 290

Paracrine signalling, 1, 314
Paraventricular nucleus, 331
Pargyline, 148

Peking duck, 72

Peptidergic nerves, 337

— neurons, 314

Peptides and blood-brain barrier, 246
Perfused dog pancreas, 102
Peripheral vascular reactivity, 676
Phentolamine, 482
Phospholipids, 67/
Phosphorylase, 343

Physical activity, 134
Pituitary hormones, 281
Placento-insular axis, 563
Platelets, 667

Polyuria, 607

Potassium, 616
Prescriptions, 468

Pregnant rat, 558
Proinsulin, 94, 669
Propranolol, 482
Proteinuria, 223, 457

Pupil dilatation, 668
Pupillography, 475
Pyruvate, 113, 482, 616

— dehydrogenase, 664

Radioimmunoassay of glucagon, 553

Rat fetus, 563

Receptor

— adrenergic, 388

— cholinergic, 388

— insulin, 636, 647

— — hypothalamic, 255

— — inrodent brain, 268

— oestradiol, 578

Red cell volume, 583

Renal plasma flow, 199, 451

Renin, 668

Reovirus type 3, 462

Retinopathy, 190, 597, see also Diabetic
retinopathy

Rheumatoid arthritis, 675

RNA, 186

Satiety, 305

Sciatic nerve, 67]

Secretin, 54

Serotonin, 148, 281, 325, 669

Sialic acid, 668

Smooth muscle cells, 155

Somatostatin

— action in brain, 299

— analogues, 299

— and glucoregulation, 1

— in human neonatal pancreas, 540

— release from isolated rat pancreatico-
duodenal preparation, 66

Subject Index

and satiety, 305
secretion
— autonomic control, 388
— CNS modulation, 417
— glucose-priming, 495
— and hypoglycaemic agents, 501
and isolated perfused pancreas, 217

— and splanchnic nerve stimulation,
102

Splanchnic nerve, 343

Starvation, 495

Steroid hormones, 246

Streptozotocin, 66, 110, 139, 205, 213,
223, 578, 675

Sulphonylurea

— dosage, 673

— therapy, 22, 118

Supra-optic nucleus, 331

Surfactant, 67]

Sympathectomy, 366

Television, 674
Thermogenesis, 362
Thiobarbituric acid, 676
Thirst, 331, 607
Thymidine, 213

Thyroid hormones, 246
Tolbutamide, 501
Trasylol, 553

TRF, 299

Triglyceride, 22
Tryptophan, 281
Turnover, 676
Tyrosine, 281

— aminotransferase, 343

Uridine, 186

Vagal

— hepatic afferents, 325

— pancreatic afferents, 325

Vagotomy, 305, 402

Vagus, 331, 343

Valsalva’s manoeuvre, 190

Vasoactive intestinal peptide, see VIP

Vasomotor nerves, 31

Vasopressin, 607

Ventro-basal thalamus, 331

Ventromedial hypothalamic nucleus,
343

— hypothalamus, 217, 402, 411

Vertical transmission, 674

Vibration sense, 670

VIP, 54, 305

Viscosity, 612

VLDL, 118

Von-Willebrand factor, 597

Zucker rat, 305

Responsible for the text: Dr. A.G. Cudworth, Department of Diabetes, Medical Unit, King George V Building (Sth Floor), St. Bartholomew’s Hospital,
London EC1A 7BE, England
Responsible for advertisements: E. Liickermann, B. Schultz, Kurfiirstendamm 237, D-1000 Berlin 15. Springer-Verlag Berlin Heidelberg New York
Printed in Germany by aprinta, Wemding
Copyright © Springer-Verlag GmbH & Co. KG, Berlin Heidelberg 1981

DELIA OOCTE

Clinical and Experimental Diabetes and Metabolism
Organ of the European Association for the Study of Diabetes (EASD)

Editor in Chief
A. G. Cudworth, London

Deputy Editors in Chief

W. J. Malaisse, Brussels
R. Tattersall, Nottingham

Associate Editors

K.G.M.M. Alberti, Newcastle-upon-Tyne
M. Berger, Dusseldorf

J. Gliemann, Aarhus
C.N. Hales, Cambridge
S. Howell, London

U. Di Mario, Rome

M. Nattrass, Birmingham
H. Orskov, Aarhus

G. Tchobroutsky, Paris

|. Valverde, Madrid

J.D. Ward, Sheffield

Volume 20/1981

Assistant Editors

H. J. Bodansky, London
B. M. Dean, London
P.L. Drury, London

A. N. Gorsuch, London
R. J. Jarrett, London
P.H. SOnksen, London
r. M. Spencer, London
W. A. Stubbs, London
D. B. J. Thomas, London

Advisory Board

K.D. Buchanan, Belfast
N. Christensen, Herlev
G. Dietze, Munich

S. Efendic, Stockholm
C. lonescu-Tirgoviste, Bucharest
J. Jervell, Oslo

U. Keller, Basel

H. M. J. Krans, Leiden
A. Lambert, Brussels

Z. Laron, Petah Tikva
E. Marliss, Toronto

R. Menzel, Karlsberg

G. Pozza, Milan

S. Raptis, Athens

G. M. Reaven, Palo Alto
J. L. Selam, Montpellier

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Contents

Editorials Angervall, L., Karlsson, K., Martinsson, A.: Effects on Rat Fe-

tuses of Intrauterine Injections of Insulin 558

Bakir, S. M., Jarrett, R. J.: The Effects of a Low-Dose Intravenous
Insulin Upon Plasma Glucose and Non-Esterified Fatty Acid
Levels in Very Obese and Non-Obese Human Subjects 592

Bereiter, D. A., Rohner-Jeanrenaud, F., Berthoud, H.-R., Jean-
renaud, B.: CNS Modulation of Pancreatic Endocrine Func-
tion. Multiple Modes of Expression 417

Bersani, G., Zanco, P., Padovan, D., Betterle, C.: Lymphocyte
Subpopulations in Insulin-dependent Diabetics with and
without Serum Islet-Cell Autoantibodies 47

Berthoud, H.-R., Bereiter, D. A., Trimble, E. R., Siegel, E. G.,
Jeanrenaud, B.: Cephalic Phase, Reflex Insulin Secretion.
Neuranatomical and Physiological Characterization 393

Bray, G. A., Inoue, S., Nishizawa, Y.: Hypothalamic Obesity. The
Autonomic Hypothesis and the Lateral Hypothalamus 366

Brown, M.: Neuropeptides: Central Nervous System Effects on
Nutrient Metabolism 299

Cannon, D.J., Conaway, H.H.: Glycosylated Haemoglobin
Levels in a Colony of Spontaneously Diabetic Rabbits 242

Castex, Ch., Sutter, B. Ch. J.: Dynamics of Insulin Release by Per-
fused Edible Dormouse (Glis glis) Pancreas. Seasonal Varia-
tions 489

Leeuw, I. De, Rooy, P. Van, D’Hollander, M.: Bone Mass in
Obese, Goldthioglucose-treated, Hyperglycaemic Mice 145

Cudworth, A.G.: 83
Sherwin, R. S., Koivisto, V.: Keeping in Step: Does Exercise Ben-
efit the Diabetic? 84

Review Articles

Barnett, A. H., Eff, C., Leslie, R. D.G., Pyke, D. A.: Diabetes in
Identical Twins. A Study of 200 Pairs 87

Sutherland, D. E. R.: Pancreas and Islet Transplantation. I. Expe-
rimental Studies 161

Sutherland, D. E. R.: Pancreas and Islet Transplantation. II. Clini-
cal Trials 435

Tattersall, R. B., Lowe, J.: Diabetes in Adolescence 517

Unger, R.H.: The Milieu Interieur and the Islets of Langer-
hans 1

Originals

Ahrén, B., Lundquist, I.: Effects of Vasoactive Intestinal Poly-
peptide (VIP), Secretin and Gastrin on Insulin Secretion in the
Mouse 54

Andersson, A., Eril.sson, U., Petersson, B., Reibring, L., Swenne,

I.: Failure of Successful Intraspienic Transplantation of Islets
from Lean Mice to Cure Obese-Hyperglycaemic Mice, Despite
Islet Growth 237

Dyrberg, T., Benn, J., Sandahl Christiansen, J., Hilsted, J., Nerup,
J.: Prevalence of Diabetic Autonomic Neuropathy Measured
by Simple Bedside Tests 190

Eckel, R.H., Fujimoto, W. Y.: Insulin-Stimulated Glucose Up-
take, Leucine Incorporation into Protein, and Uridine Incor-
poration into RNA in Skin Fibroblast Cultures from Patients
with Diabetes Mellitus 186

Ekka, E., Vanderheyden, I., Hertogh, R. De: Oestrogen Recep-
tors and Oestrogen-Induced Protein Synthesis in the Uterus of
Diabetic Rats 578

Felber, J.-P., Meyer, H. U., Curchod, B., Iselin, H. U., Rousselle,
J., Maeder, E., Pahud, P., Jéquier, E.: Glucose Storage and
Oxidation in Different Degrees of Human Obesity Measured
by Continuous Indirect Calorimetry 39

Feldman, J. M., Vervaert, C., Klatt, C., Seigler, H. F.: Therapy of
Malignant Hamster Insulinomas with Monoamine Precur-
sors 148

Fernstrom, J. D.: Effects of Precursors on Brain Neurotransmitter
Synthesis and Brain Functions 281

Flatt, P. R., Bailey, C. J.: Abnormal Plasma Glucose and Insulin
Responses in Heterozygous Lean (ob/+) Mice 573

Frayn, K. N.: Effects of Diabetes and of Injury on Muscle Protein
in the Mouse, and Their Interaction 139

Fujimoto, K., Sakaguchi, T., Ui, M.: Adrenergic Mechanisms in
the Hyperglycaemia and Hyperinsulinaemia of Diabetic KK
Mice 568

Girardier, L., Seydoux, J.: Is There a Sympathetic Regulation of
the Efficiency of Energy Utilization? 362

Goldman, J. K., Bernardis, L. L., MacKenzie, R. G., Kodis, M.,
Luboshitzky, R.: Effects of Ventromedial Hypothalamic Le-
sions on Adipose Tissue of Weanling Male Rats 357

Goto, Y., Berelowitz, M., Frohman, L. A.: Acute Effects of Al-
loxan- and Streptozotocin-induced Insulin Deficiency on So-
matostatin and Glucagon Secretion by the Perfused Isolated
Rat Pancreatico-duodenal Preparation 66

Gray, R.S., Herd, R., Clarke, B. F.: The Clinical Features of Dia-
betes with Coexisting Autoimmune Thyroid 602

Green, A., Hauge, M., Holm, N. V., Rasch, L. L.: Epidemiological
Studies of Diabetes Mellitus in Denmark. II. A Prevalence
Study Based on Insulin Prescriptions 468

Grill, V., Rundfeld, M., Efendi¢, S.: Previous Exposure to Glucose
Enhances Somatostatin Secretion from the Isolated Perfused
Rat Pancreas 495

Grover-Johnson, N. M., Baumann, F. G., Imparato, A. M., Kim,
G. E., Thomas, P. K.: Abnormal Innervation of Lower Limb
Epineurial Arterioles in F.uman Diabetes 31

Havrankova, J., Brownstein, M., Roth, J.: Insulin and Insulin Re-
ceptors in Rodent Brain 268

Hendriks, T., Benraad, T. J.: On the Stability of Immunoreactive
Glucagon in Plasma Samples 553

Henze, K., Chait, A.: Lysosomal Enzyme Activities and Low-
Density Lipoprotein Receptors in Circulating Mononuclear
Cells. Effect of Insulin Therapy in Diabetic Patients 625

Houten, M. van, Posner, B.I.: Cellular Basis of Direct Insulin
Action in the Central Nervous System 255

Hreidarsson, A.B.: Acute, Reversible Autonomic Nervous Sys-
tem Abnormalities in Juvenile Insulin-Dependent Diabetes. A
Pupillographic Study 475

Kay, R. M., Grobin, W., Track, N. S.: Diets Rich in Natural Fibre
Improve Carbohydrate Tolerance in Maturity-onset, Non-
insulin Dependent Diabetics 18

Kim, Y.S., Yoon, Y., Jatoi, I., Kim, Y.: Fetal Macrosomia in
Diabetic Multiparous Animals 213

Laurent, F., Gross, R., Lakili, M., Mialhe, P.: Effect of Insulin on
Glucagon Secretion Mediated Via Glucose Metabolism of
Pancreatic A Cells in Ducks 72

Lernmark, A., Hagglof, B., Freedman, Z., Irvine, J., Ludvigsson,
J., Holmgren, G.: A Prospective Analysis of Antibodies Re-
acting with Pancreatic Islet Cells in Insulin-Dependent Dia-
betic Children 471

Il

Lilavivat, U., Brodows, R. G., Campbell, R. G.: Adrenergic Influ-
ence on Glucocounterregulation in Man 482

Lindgarde, F., Saltin, B.: Daily Physical Activity, Work Capacity
and Glucose Tolerance in Lean and Obese Normoglycaemic
Middleaged Men 134

Lisch, H.-J., Sailer, S.: Lipoprotein Patterns in Diet, Su!phonyl-
urea, and Insulin Treated Diabetics 118

Lougheed, W. D., Fischer, U., Perlman, K., Albisser, A.M.: A
Physiological Solvent for Crystalline Insulin 51

Madsbad, S., Krarup, T., Regeur, L., Faber, O. K., Binder, C.:
Effect of Strict Blood Glucose Control on Residual B-Cell
Function in Insulin-Dependent Diabetics 530

Metcalfe, P., Johnston, D. G., Nosadini, R., O@rskov, H., Alberti,
K.G.M.M.: Metabolic Effects of Acute and Prolonged
Growth Hormone Excess in Normal and Insulin-deficient
Man 123

Milles, J. J., Baylis, P. H., Wright, A. D.: Plasma Vasopressin Du-
ring Insulin Withdrawal in Insulin-Dependent Diabetes 607

Monnier, L.H., Blotman, M.J., Colette, C., Monnier, M. P.,
Mirouze, J.: Effects of Dietary Fibre Supplementation in Sta-
ble and Labile Insulin-dependent Diabetics 12

Nicolaidis, S.: Lateral Hypothalamic Control of Metabolic Factors
Related to Feeding 426

Nielsen, J. H., Eff, C., Deckert, T., Andersson, A.: Stimulatory
Effect of Serum from Diabetic Patients on Insulin Release
from Mouse Pancreatic Islets Maintained in Tissue Cul-
ture 60

Niijima, A.: Visceral Afferents and Metabolic Function 325

Nosadini, R., Noy, G.A., Alberti, K.G.M.M., Hodson, A.,
@rskov, H.: The Metabolic Response to Hyperglycaemic
Clamping in Insulin-dependent Diabetes 113

Novin, D., Rogers, R.C., Hermann, G.: Visceral Afferent and
Efferent Connections in the Brain 331

O’Connor, N., Tredger, J., Morgan, L.: Viscosity Differences Be-
tween Various Guar Gums 612

Oomura, Y., Kita, H.: Insulin Acting as a Modulator of Feeding
through the Hypothalamus 290

Panzram, G., Zabel-Langhennig, R.: Prognosis of Diabetes Mel-
litus in a Geographically Defined Population 587

Pardridge, W. M.: Transport of Nutrients and Hormones through
the Blood-Brain Barrier 246

Parving, H.-H., Smidt, U. M., Friisberg, B., Bonnevie-Nielsen, V.,
Andersen, A. R.: A Prospective Study of Glomerular Filtra-
tion Rate and Arterial Blood Pressure in Insulin-Dependent
Diabetics with Diabetic Nephropathy 457

Pedersen, O., Gliemann, J.: Hexose Transport in Human Adi-
pocytes: Factors Influencing the Response to Insulin and Ki-
netics of Methylglucose and Glucose Transport 630

Pedersen, O., Hjollund, E., Beck-Nielsen, H., Lindskov, H. O.,
Sonne, O., Gliemann, J.: Insulin Receptor Binding and Recep-
tor-Mediated Insulin Degradation in Human Adipocytes 636

Pennell, J.P., Yanagawa, N., Hwang, K.H., Millard, M.M.,
Bourgoignie, J.J.: Glomerular Selective Permeability to
Macromolecular Neutral Dextrans in Experimental Dia-
betes 223

Pfeifle, B., Ditschuneit, H.: Effect of Insulin on Growth of Cul-
tured Human Arterial Smooth Muscle Cells 155

Pierluissi, R., Pierluissi, J., Ashcroft, S.J.H.: Effects of an
Enkephalin Analogue (DAMME) on Insulin Release from
Cultured Rat Islets of Langerhans 642

Pipeleers, D. G., Pipeleers-Marichal, M. A.: A Method for the
Purification of Single A, B and D Cells and for the Isolation of
Coupled Cells from Isolated Rat Islets 654

Porte, D. Jr., Woods, S. C., Jeanrenaud, B., Berthoud, H. R.: Dia-
betes and the Nervous System 245

Porte, D. Jr., Woods, S. C.: Regulation of Food Intake and Body
Weight by Insulin 274

IV

Powley, T.L., Laughton, W.: Neural Pathways Involved in the
Hypothalamic Integration of Autonomic Responses 378
Rahier, J., Wallon, J., Henquin, J.-C.: Cell Populations in the
Endocrine Pancreas of Human Neonates and Infants 540
Reinila, A.: Long-term Effects of Untreated Diabetes on the Ar-
terial Wall in Rat. An Ultrastructural Study 205

Ribes, G., Trimble, E. R., Blayac, J. P., Wollheim, C. B., Puech,
R., Loubatiéres-Mariani, M.M.: Effect of a New Hypo-
glycaemic Agent (HB 699) on the In Vivo Secretion of Pan-
creatic Hormones in the Dog 501

Rohner-Jeanrenaud, F., Jeanrenaud, B.: Possible Involvement of
the Cholinergic System in Hormonal Secretion by the Perfused
Pancreas from Ventromedial-Hypothalamic Lesioned
Rats 217

Roy, M. W., Jones, M.S., Miller, R. E.: Pancreatic Somatostatin
Secretion is Suppressed by Splanchnic Nerve Stimulation 102

Samols, E., Stagner, J.1I., Weir, G.C.: Autonomic Function and
Control of Pancreatic Somatostatin 388

Sandahl Christiansen, J., Gammelgaard, J., Frandsen, M., Parving,
H.-H.: Increased Kidney Size, Glomerular Filtration Rate and
Renal Piasma Flow in Short-Term Insulin-Dependent Dia-
betics 451

Sandahl Christiansen, J., Frandsen, M., Parving, H.-H.: The Effect
of Intravenous Insulin Infusion on Kidney Function in Insulin-
Dependent Diabetes Mellitus 199

Sasaki, A.: Assessment of the New Criteria for Diabetes Mellitus
According to 10-year Relative Survival Rates 195

Schneider, S.H., Fineberg, S.E., Blackburn, G.L.: The Acute
Metabolic Effects of Glucagon and Its Interaction with Gluca-
gon in Forearm Tissue 616

Sclafani, A.: The Role of Hyperinsulinemia and the Vagus Nerve
in Hypothalamic Hyperphagia Reexamined 402

Sensi, M., Pozzilli, P., Gorsuch, A. N., Bottazzo, G. F., Cudworth,
A.G.: Increased Killer Cell Activity in Insulin Dependent
(Type 1) Diabetes Mellitus 106

Shimazu, T.: Central Nervous System Regulation of Liver and
Adipose Tissue Metabolism 343

Sidenius, P., Jakobsen, J.: Retrograde Axonal Transport. A Possi-
ble Role in the Development of Neuropathy 110

Skrha, J., Stépan, J., Havranek, T., Skrha, F., Herfort, K., Sram-
kova, J., Pav, J.: Isoamylases in Diabetes Mellitus 129

Smith, P.H., Madson, K.L.: Interactions between Autonomic
Nerves and Endocrine Cells of the Gastroenteropancreatic
System 314

Sodoyez-Goffaux, F., Soyodez, J. C., De Vos, C. J.: Evidence for a
Placento-Insular Axis in the Rat Fetus 563

Sdnksen, P. H., Lowy, C., Perkins, J. R., West, T. E. T.: Hormonal
and Metabolic Effects of Chlorpropamide, Glibenclamide and
Placebo in a Cross-over Study in Diabetics not Controlled by
Diet Alone 22

Starke, A., Keck, E., Berger, M., Zimmermann, H.: Effects of
Calcium and Calcitonin on Circulating Levels of Glucagon and
Glucose in Diabetes Mellitus 547

Steffens, A. B.: The Modulatory Effect of the Hypothalamus on
Glucagon and Insulin Secretion in the Rat 411

Strubbe, J. H., Wachem, P. van: Insulin Secretion by the Trans-
planted Neonatal Pancreas during Food Intake in Fasted and
Fed Rats 228

Suarez, B. K., Eerdewegh, P. Van: Type I (Insulin Dependent)
Diabetes Mellitus 524

Taylor, K. G., Wright, A. D., Carter, T. J. N., Valente, A. J., Betts,
S. A., Matthews, K. A.: High-Density Lipoprotein Cholesterol

and Apolipoprotein A-I Levels at Diagnosis in Patients with
Non-Insulin Dependent Diabetes 535

Uvnis-Wallensten, K.: Peptides in Metabolic Autonomic
Nerves 337

Verdonck, L. F., Sangster, B., Heijst, A. N. P. van, de Groot, G.,
Maes, R. A. A.: Buformin Concentrations in a Case of Fatal
Lactic Acidosis 45

Woods, S.C., West, D.B., Stein, L.J., McKay, L.D., Lotter,
E.C., Porte, S.G., Kenney, N.J., Porte, D. Jr.: Peptides and
the Control of Meal Size 305

Yoon, J. W., Selvaggio, S., Onodera, T., Wheeler, J., Jenson,
A.B.: Infection of Cultured Human Pancreatic B Cells with
Reovirus Type 3 462

Short Communications

Davidson, R. J. L., Evan-Wong, L. A., Stowers, J. M.: The Mean
Red Cell Volume in Diabetes Mellitus 583

Letters to the Editor

Barbosa, J., Ramsay, R.: Of Genes and Proliferative Retino-
pathy 506

Bodansky, H.J., Wolf, E.: HLA Association with Diabetic Reti-
nopathy-Factor Fancy? 585

Bottermann, P.: Rapid Fluctuations in Glycosylated Haemoglobin
Concentration 159

Burke, B.J., Owens, C.J., Pennock, C. A.: Cord Blood C-Pep-
tide: Glucose Ratio — a Good Indicator of B Cell Function in
Infants of Diabetic Mothers 511

Gordon, D. A., MacKenzie, G. H., Toledo-Pereyra, L. H.: Effi-
cient Pancreatic Islet Cell Preparation Utilizing a New Tissue
Chopper Prior to Transplantation 79

Ionescu-Tirgoviste, C., Popa, E., Cheto, D.: Delayed Menarche as
an Indicator of a Prediabetic State 510

Jarrett, R. J.: How Much Carbohydrate? 507

Lechin, F., Dijs, B. van der: Haloperidol and Insulin Release 78

Mann, J.1., Simpson, H.C. R., Hockaday, T.D.R.: 507

Micossi, P.: The Prevalence of Chlorpropamide Alcohol Flushing
in Non-Insulin Dependent Diabetics 510

Paisey, R., Pennock, C., Owens, C., Hartog, M., White, D.: Rapid
Glycosylation of Haemoglobin 80

Reaven, G.M.: 508

Vierhapper, H., Bratusch-Marrain, P., Waldhausl, W.: Long-Term
Treatment of Sulphonylurea-Treated Diabetics with the
a-Glucosidase Inhibitor Bay g 5421 (Acarbose) 586

Wieling, W., Brederode, J. F.M. van, Borst, C.: A New Test to
Study Diabetic Autonomic Neuropathy 244

Abstracts
Meeting of the Medical and Scientific Section of the British Dia-

betic Association, Cambridge, United Kingdom, March 27-28,
1981

Organization Section
81, 160, 512

Author Index and Subject Index are published on pages 679-684 at the end of the volume

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